Atopic eczema: a disease modulated by gene and environment

Mao, Weian; Mao, Jingyi; Zhang, Jian; Wang, Li; Cao, D.; Qu, Yi

doi:10.2741/4237

Cited by 8 publications

(2 citation statements)

References 105 publications

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“…Many patients also have allergic asthma, food allergies, and allergic rhinitis. In addition, nonimmune factors such as stress, anxiety, and other negative emotions, can also aggravate AD [7][8][9][10][11][12][13][14][15][16]. Its incidence has increased worldwide in recent years, especially in high-income and industrialized countries because of air pollution and household hygiene products [16].…”

Section: Introductionmentioning

confidence: 99%

Guidelines for the Management of Atopic Dermatitis in Children: A Systematic Review

Wang

Liu

2022

Int Arch Allergy Immunol

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Introduction: Numerous guidelines have been published for atopic dermatitis management in children in recent years. To date, the quality of the newest guidelines has not been appraised. This study aimed to identify and evaluate guidelines for the management of atopic dermatitis in children. Methods: We reviewed the literature retrieved from PubMed, Web of Science, Ovid, ScienceDirect, Embase, China National Knowledge Infrastructure, WanFang Data, and guidelines websites. Search period from January 1, 2016, to December 31, 2021. The following keywords were used for searching: “atopic dermatitis,” “atopic eczema,” “eczema,” “guideline,” and “consensus.” The quality of the guidelines was assessed by two assessors using the Appraisal of Guidelines for Research & Evaluation II (AGREE II) instrument independently, and domain scores >60% were considered to have sufficient quality. The guideline recommendations were reviewed. Results: Nineteen guidelines were included in the study. Three guidelines had a graded A level, which was recommended for use in practice. Eleven guidelines had a graded B level, which was recommended for use in revision. The remaining five guidelines were rated with C level, which was not recommended. The average score of six domains of AGREE II was 64.76%, 48.53%, 42.35%, 73.83%, 32.23%, and 70.17%, respectively. A consistency test showed an intraclass correlation coefficient range of 0.497 (95% CI: 0.105, 0.705) to 0.970 (95% CI: 0.93, 0.987) based on the two assessors’ test results for the guidelines. Conclusions: Most guidelines were recommended for use with revision. No significant changes were observed in the primary management of atopic dermatitis in children compared to previous evidence. New biological agents and complementary alternative medicine are increasingly available, but the evidence for the treatment of atopic dermatitis in children is still limited.

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Section: Introductionmentioning

confidence: 99%

Guidelines for the Management of Atopic Dermatitis in Children: A Systematic Review

Wang

Liu

2022

Int Arch Allergy Immunol

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“…In addition, non-immune factors such as stress, anxiety and other negative emotions can also aggravate AD. [7][8][9][10][11][12][13][14] The diagnosis of AD is based on the clinical history and skin symptoms, other tests such as patch testing and food challenge test are also used. 15,16 The worldwide diagnosis criteria are Williams Diagnostic Criteria from the UK and Hanifin-Rajka Diagnostic Criteria.…”

Section: Introductionmentioning

confidence: 99%

Guidelines for the management of atopic dermatitis in children: A systematic review of the literature and quality appraisal with AGREE II

Wang

Liu

2022

Preprint

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Background: Numerous guidelines have been published for atopic dermatitis management in children in recent years. To date, the quality of the newest guidelines has not been appraised. Objective: To identify and evaluate guidelines for the management of atopic dermatitis in children. Design: A review of the guidelines for the management of atopic dermatitis in children and quality appraisal with AGREE II was conducted. Methods: We reviewed literature retrieved from PubMed, Web of Science, Ovid, ScienceDirect, Embase, China National Knowledge Infrastructure, WanFang Data, and guidelines websites. Search period from 1 January 2016 to 31 December 2021. The following keywords were used for searching: ‘atopic dermatitis’, ‘atopic eczema’, ‘eczema’, ‘guideline’ and ‘consensus’. The quality of the guidelines was assessed by two assessors using the Appraisal of Guidelines for Research & Evaluation II (AGREE II) instrument independently, and domain scores were considered of sufficient quality when > 60%. Guidelines recommendations were reviewed. Results: Nineteen guidelines were included in the study. Three guidelines were graded A level that recommended for use in practice. Eleven guidelines were graded B level that recommended for use in revision. The remaining five guidelines were rated C level not as recommended. The average score of six domains of AGREE II was 64.76%, 48.53%, 42.35%, 73.83%, 32.23% and 70.17%, respectively. The consistency test showed that ICC ranged from 0.497 (95%CI: 0.105, 0.705) to 0.970 (95%CI: 0.93, 0.987) in the results of two assessors’ tests of the guidelines. Conclusions: Most guidelines were recommended for use with revision in the study. No major changes in primary management of atopic dermatitis in children compared to previous evidence. New biologic agents and complementary alternative medicine were increasingly available, but evidence for the treatment of atopic dermatitis in children was still limited.

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