Atopy—A favourable prognostic factor for survival in Hodgkin's disease

Amlot, Peter; Slaney, J. M.; Brown, Robert S.

doi:10.1038/bjc.1983.176

Cited by 12 publications

(5 citation statements)

References 24 publications

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“…We also analysed several cancer sites previously reported to have an association with allergy either protective or with an increased risk. None of these sites: lung (15, 18, 33, 36, 40), cervix (15, 32), pancreas (25) and lymphoma (14, 35, 37) had an association with allergy in our study. Also, we found no increased risk for nonmelanoma skin cancer, which is in line with a recent study (42).…”

Section: Discussioncontrasting

confidence: 55%

“…Patients with allergies have hypothetically an overactivity of their immunological mechanisms and thus the presence of clinical allergy might be protective with regard to the development of cancer. To date, a number of studies have reported a protective effect (1–27) but other studies have found allergy to be a risk factor for cancer (28–33) and some have found no correlation or conflicting results (34–43). Many of these studies have had the major drawback of not surveying large enough populations, or defining their patients with allergies from data derived from interviews or questionnaires.…”

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confidence: 99%

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Allergy and cancer

Lindelöf¹,

Granath

Tengvall-Linder

et al. 2005

Allergy

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Section: Discussioncontrasting

confidence: 55%

mentioning

confidence: 99%

Allergy and cancer

Lindelöf¹,

Granath

Tengvall-Linder

et al. 2005

Allergy

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“…Based upon our results, we speculate that another group of susceptibility genes, perhaps shared between individuals afflicted with atopic or autoimmune diseases, may affect the downregulation of immune responses mediated by regulatory T cells. Interestingly, a negative correlation between atopic condition and the incidence/severity of certain cancers has been reported (72)(73)(74)(75). As the experimental depletion of CD25 ϩ regulatory T cells in mice inoculated with syngeneic tumors leads to increased killer activity, decreased tumor size and reduced cancer-related death (76,77), it is possible that the level of regulatory T cell activity of each individual is one of the determinants of the ease in which T helper-dependent responses occur.…”

Section: Discussionmentioning

confidence: 99%

Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes✪

Lafaille

Muriglan

Sunshine

et al. 2001

The Journal of Experimental Medicine

100

101

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A key event in the pathogenesis of allergies is the production of antibodies of the immunoglobulin (Ig)E class. In normal individuals the levels of IgE are tightly regulated, as illustrated by the low serum IgE concentration. In addition, multiple immunizations are usually required to generate detectable IgE responses in normal experimental animals. To define the parameters that regulate IgE production in vivo, we generated mice bearing monoclonal populations of B and T lymphocytes specific for influenza virus hemagglutinin (HA) and chicken ovalbumin (OVA), respectively. A single immunization of the monoclonal mice with the cross-linked OVA-HA antigen led to serum IgE levels that reached 30-200 g/ml. This unusually high IgE response was prevented by the infusion of regulatory ␣ / ␤ CD4 ϩ T cells belonging to both CD25 ϩ and CD25 Ϫ subpopulations. The regulation by the infused T cells impeded the development of fully competent OVA-specific effector/memory Th2 lymphocytes without inhibiting the initial proliferative response of T cells or promoting activation-induced cell death. Our results indicate that hyper IgE responses do not occur in normal individuals due to the presence of regulatory T cells, and imply that the induction of regulatory CD4 ϩ T cells could be used for the prevention of atopy.

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“…The pathogenesis of HL has not been fully defined, nor has a characteristic genomic defect specific to the malignant HRS cell been identified (3, 4). Primary HRS cells, HL-derived cell lines and cells in the surrounding reactive infiltrate produce numerous cytokines and chemokines (5, 6), and pre-treatment serum levels of these molecules have been evaluated as prognostic biomarkers (7–11). …”

Section: Introductionmentioning

confidence: 99%

Elevated Serum Levels of sCD30 and IL6 and Detectable IL10 Precede Classical Hodgkin Lymphoma Diagnosis

Levin

Breen

Birmann

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background We investigated whether an immune system environment characterized by elevated serum levels of B-cell activation molecules was associated with the subsequent development of classical Hodgkin lymphoma (cHL). Methods We measured serum levels of B-cell-stimulatory cytokines, interleukin (IL)-6 and IL-10, soluble CD30 (sCD30) and total IgE prior to cHL diagnosis in 103 cases and 206 matched controls with archived specimens in the DoD Serum Repository. Results Pre-diagnosis serum sCD30 and IL-6 levels had strong positive associations with risk of a cHL diagnosis >0-1 year prior to diagnosis (sCD30 odds ratio [OR] =5.5, 95% confidence interval [CI] = 3.4–9.0; IL-6 OR = 4.6, 95% CI = 2.9–7.5) and >1 year to 2 years pre-cHL diagnosis (sCD30 OR =3.3, 95% CI = 1.6–6.7; IL-6 OR = 2.9, 95% CI = 1.3–6.5). We observed similar, albeit not consistently significant positive associations, over four or more years preceding diagnosis. We did not observe a clear association with IgE levels. Of note, detectable IL-10 levels were significantly associated with Epstein-Barr virus (EBV)-positive cHL cases compared with EBV-negative cases. Conclusion In this prospective analysis, elevated sCD30 and IL-6 levels and detectable IL-10 preceded cHL diagnosis. Impact The associations of these cytokines with cHL risk may reflect the production of these molecules by proliferating nascent cHL tumor cells, or by immune cells responding to their presence, prior to clinical detection. The stable elevation in cHL risk, four or more years pre-diagnosis, also suggests that a B-cell-stimulatory immune system milieu precedes, and may promote, lymphomagenesis.

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Atopy—A favourable prognostic factor for survival in Hodgkin's disease

Cited by 12 publications

References 24 publications

Allergy and cancer

Allergy and cancer

Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes✪

Elevated Serum Levels of sCD30 and IL6 and Detectable IL10 Precede Classical Hodgkin Lymphoma Diagnosis

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