Atopy and Keratoconus*

Galin, Miles A.; Berger, Robert

doi:10.1016/0002-9394(58)90403-3

Cited by 69 publications

(17 citation statements)

References 4 publications

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“…3,12,18,79,84,85 However, the effect of atopy is controversial. 86,87 Several authors did not find a statistically significant difference between a group of control and keratoconic patients. 31,88 Yet, Kaya et al 85 showed that individuals with keratoconus and atopy had a steeper and thinner ectatic area than individuals with keratoconus but without atopy.…”

Section: Atopymentioning

confidence: 97%

The Epidemiology and Etiology of Keratoconus

Gordon‐Shaag¹,

Millodot²,

Shneor³

2012

International Journal of Keratoconus and Ectatic Corneal Diseases

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Keratoconus is a noninflammatory disorder characterized by ectasia of the central or inferior portion of the cornea. This review presents the scant epidemiological information known to date and the factors believed to cause the development of the disease. They are the genetic factors for which evidence come from family studies, twin studies and genetic loci. There appears to be multiple genes causing a keratoconus phenotype with variable penetration. However, the genetic predisposition might not be enough; environmental factors, such as eye rubbing, atopy and UV exposure, may have a role in generating the disease.

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Section: Atopymentioning

confidence: 97%

The Epidemiology and Etiology of Keratoconus

Gordon‐Shaag¹,

Millodot²,

Shneor³

2012

International Journal of Keratoconus and Ectatic Corneal Diseases

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“…In the present series, of the patients with chronic atopic dermatitis 31.8% had conjunctivitis and 6.8% superficial keratitis. Some investigators [7,17] have reported a rather high incidence of keratoconus and have tried to correlate the development of keratoconus with the onset of puberty when atopic dermatitis is apt to recur. However, severity of the keratoconus has not been documented, although keratoconus has sev eral stages.…”

Section: Discussionmentioning

confidence: 99%

Ocular Findings in Atopic Dermatitis with Special Reference to the Clinical Features of Atopic Cataract

Amemiya

Matsuda

Uehara³

1980

Ophthalmologica

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44 patients with atopic dermatitis who had had active generalized skin lesions, especially of the face, following transient remission after eczema in infancy were examined ophthalmologically. Their ocular findings have been correlated with the clinical features of atopic dermatitis. 25% of the patients with this clinical course had cataracts. However, the clinical features of the patients without cataracts were almost the same as those of the patients with. Thus, cataracts in patients with atopic dermatitis may not be due to the clinical symptoms and course but to other factors such as genetic, as in the case of asthma. Lenticular opacities were present in the posterior subcapsule in 50%, in the anterior subcapsule in 25% and throughout the lens in 12.5%. 2 patients with total lens opacities had shown rapid progression at the time of exacerbation of the skin lesions. Chronic conjunctivitis was found in 31.8%, superficial keratitis in 6.8% and retinal detachment in 2%.

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“…This association was first reported in 1937 by Higartner et al 3 Later, many studies contradicted this finding. [4][5][6][7] In a controlled study, Lowell and Carroll 8 reported that there was no statistically significant difference between the group of keratoconus patients and the control group with respect to the presence of atopy. Nevertheless, in 1965, Copman 9 reported that, in the healthy population, 3% of the subjects had eczema, whereas in patients with keratoconus, 32% of the patients had eczema.…”

mentioning

confidence: 97%