Atorvastatin Accelerates Both Neointimal Coverage and Re-Endothelialization After Sirolimus-Eluting Stent Implantation in a Porcine Model

Abstract

Atorvastatin pretreatment can accelerate both neointimal coverage and re-endothelialization after SES implantation, which may be mediated by the mobilization of EPC and enhancement of the endothelial function of the neointima.

Influence of Late Vascular Inflammation on Long‐Term Outcomes Among Patients Undergoing Implantation of Drug Eluting Stents: Role of C‐Reactive Protein

“…Moreover, a favorable effect of statins on reendothelialization after DES implantation may influence the outcome. 20 According to recent pathological investigations, inflammation at stented sites was less severe in patients with newer DES than in those with first-generation DES, 4 and the lower CRP value in our patients with newer DES was compatible with that pathological finding. Recent use of biocompatible polymer and optimized drug dose contributes to these results of newer DES.…”

“…The pleotropic anti‐inflammatory effects of statins could reduce late‐phase inflammation after DES implantation as previously reported and thus decrease MACE. Moreover, a favorable effect of statins on reendothelialization after DES implantation may influence the outcome …”

Effect of High-Dose Atorvastatin Reload on the Release of Endothelial Progenitor Cells in Patients on Long-Term Statin Treatment Who Underwent Percutaneous Coronary Intervention (from the ARMYDA-EPC Study)

“…Walter et al 7 showed an accelerated rate of re-endothelization in simvastatintreated rats after balloon-induced ischemia, with concomitant increases in levels and adhesive properties of EPCs. Wang et al, 20 in a porcine model of PCI, found that atorvastatin pretreatment promotes neointimal coverage and reendothelization after sirolimus-eluting stent implantation, with a more pronounced EPC mobilization and improvement of endothelial function. The present study was specifically focused on the evaluation of statin efficacy in promoting EPC mobilization in the context of PCI patients.…”

Statins and prevention of stent-related late adverse events

“…Supporting this theory, a recent study using a porcine model with DES implantation showed that atorvastatin accelerated both neointimal proliferation and re-endothelialization after the DES through mobilization of EPCs and enhancement of neointima endothelial function [13]. It is evident that statins reduce atherosclerotic cardiovascular adverse events in a wide variety of patient populations through direct LDL-lowering effects.…”