Atorvastatin and sildenafil interaction-induced rhabdomyolysis

Salem, Chaker Ben; Sahnoun, D.; Slim, Raoudha; Fradj, Fatma Ben; Aouani, Chedia

doi:10.1177/1060028020919933

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…( Feng et al, 2020 ). However, due to the existence of various adverse drug reactions, such as vascular restenosis ( Waksman and Iantorno 2018 ), drug intolerance ( Nicola and Ho 2019 ), and rhabdomyolysis ( Ben Salem et al, 2020 ), the benefits of intensive statin therapy need to be balanced with the potential risks they may cause. To address this dilemma, natural products have been the focus of both academics and the pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

A review on therapeutical potential of paeonol in atherosclerosis

Ilyas

Aktar

et al. 2022

Front. Pharmacol.

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The morbidity and mortality of atherosclerotic cardiovascular disease (ASCVD) is increasing year by year. Cortex Moutan is a traditional Chinese medicinal herb that has been widely used for thousands of years to treat a wide variety of diseases in Eastern countries due to its heat-clearing and detoxifying effects. Paeonol is a bioactive monomer extracted from Cortex Moutan, which has anti-atherosclerotic effects. In this article, we reviewed the pharmacological effects of paeonol against experimental atherosclerosis, as well as its protective effects on vascular endothelial cells, smooth muscle cells, macrophages, platelets, and other important cell types. The pleiotropic effects of paeonol in atherosclerosis suggest that it can be a promising therapeutic agent for atherosclerosis and its complications. Large-scale randomized clinical trials are warranted to elucidate whether paeonol are effective in patients with ASCVD.

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Section: Introductionmentioning

confidence: 99%

A review on therapeutical potential of paeonol in atherosclerosis

Ilyas

Aktar

et al. 2022

Front. Pharmacol.

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“…Advances in medical technology have led to the discovery of drugs and interventional therapies for atherosclerotic cardiovascular disease ( 1 ). However, available drugs are associated with various adverse effects, including high tolerance ( 2 , 3 ), rhabdomyolysis ( 4 ), and restenosis ( 5 ). It has been shown that natural compounds may confer protection against atherosclerotic cardiovascular disease through various mechanisms ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview

et al. 2021

Front. Cardiovasc. Med.

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With improvement in living standards and average life expectancy, atherosclerotic cardiovascular disease incidences and mortality have been increasing annually. Paeonia suffruticosa, a natural herb, has been used for the treatment of atherosclerotic cardiovascular disease for thousands of years in Eastern countries. Paeonol is an active ingredient extracted from Paeonia suffruticosa. Previous studies have extensively explored the clinical benefits of paeonol. However, comprehensive reviews on the cardiovascular protective effects of paeonol have not been conducted. The current review summarizes studies reporting on the protective effects of paeonol on the cardiovascular system. This study includes studies published in the last 10 years. The biological characteristics of Paeonia suffruticosa, pharmacological mechanisms of paeonol, and its toxicological and pharmacokinetic characteristics were explored. The findings of this study show that paeonol confers protection against atherosclerotic cardiovascular disease through various mechanisms, including inflammation, platelet aggregation, lipid metabolism, mitochondria damage, endoplasmic reticulum stress, autophagy, and non-coding RNA. Further studies should be conducted to elucidate the cardiovascular benefits of paeonol.

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Atorvastatin/sildenafil interaction

2020

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Atorvastatin and sildenafil interaction-induced rhabdomyolysis

Cited by 7 publications

References 8 publications

A review on therapeutical potential of paeonol in atherosclerosis

A review on therapeutical potential of paeonol in atherosclerosis

Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview

Atorvastatin/sildenafil interaction

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