Atorvastatin Decreases Renal Calcium Oxalate Stone Deposits by Enhancing Renal Osteopontin Expression in Hyperoxaluric Stone-Forming Rats Fed a High-Fat Diet

Liu, Chan Jung; Tsai, Yau Sheng; Huang, Huey W.

doi:10.3390/ijms23063048

Cited by 7 publications

(6 citation statements)

References 40 publications

(53 reference statements)

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“…The mechanism of the association between lipid metabolism data and renal calculi is still unclear. First all, abnormal lipid metabolism may affect the pH value or mineral concentration of urine, thus affecting the formation of kidney stones [21] . For example, TG and TC can affect the oxalate/calcium ion ratio in urine, the solubility of uric acid crystals and the formation of crystal nuclei.…”

Section: Discussionmentioning

confidence: 99%

Clinical Lipid Metabolism Correlates with Urinary Calculus: TyG Index Has a Closer Correlation

Pan

Zhang

et al. 2023

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Aims:We aimed to assess the association between lipid metabolism and kidney stones in Chinese adults. Methods:Data were obtained from the clinical data of our center in the past 3 years. The analysis included complete data on blood lipids and kidney stones in participants aged ≥18 years and non-stone controls. Weighted multivariate regression analysis and subgroup analysis were used to estimate the relationship between various lipid indexes and nephrolithiasis and burden and recurrence. Results: A total of 414 participants were included in the study, and their gender, age and other basic indicators showed no significant differences. In the adjusted logistic regression analysis results, the prevalence of kidney stones increased with the increase of triglyceride (TG), triglyceride-glucose (TyG) index and Apolipoprotein A-I (AIP) [TG: odds ratio (OR)= 2.14; 95% CI: 1.62-2.81; p < 0.001; TyG: OR=4.30; 95% CI: 2.75-6.72; p < 0.001; AIP: OR=10.12; 95% CI: 4.58-22.35; p < 0.001]. There was still a significant correlation with TyG index in the subgroup analysis of burden (OR=1.52; 95% CI: 1.04-2.22; p < 0.05) and recurrence (OR=2.77; 95% CI: 1.08-7.13; p < 0.05). Conclusions:Lipid metabolism is closely related to urinary system stones, and a higher TyG index is associated with an increased risk of kidney stone incidence, burden, and recurrence. We hypothesize that timely treatment and management of abnormal lipid metabolism may help improve or alleviate the occurrence, burden, and recurrence of urinary system stones. However, further large-scale prospective studies and basic experiments are still needed to clarify the exact causal relationship of this association.

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Section: Discussionmentioning

confidence: 99%

Clinical Lipid Metabolism Correlates with Urinary Calculus: TyG Index Has a Closer Correlation

Pan

Zhang

et al. 2023

Preprint

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“…These mice also exhibited a notable increase in oxalic acid levels in their urine [ 41 ]. In contrast, the administration of statin treatment in high-fat diet-fed mouse models led to increased renal osteopontin expression and reduced deposition of calcium oxalate stones [ 42 ]. The strong association between dyslipidemia, one of the important indicators for calculating the visceral fat accumulation index, and the progression of kidney stones explains the increased risk of kidney stones due to high VAI levels.…”

Section: Discussionmentioning

confidence: 99%

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

Liang,

Liu,

Yang

2023

BMC Nephrol

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Aim Our aim in this study was primarily to assess the relationship between visceral adiposity index (VAI) and the risk of kidney stones and kidney stone recurrence in US adults. Methods We used data from the National Health and Nutrition Examination Survey (NHANES) 2007–2014 for our analysis. VAI was calculated from waist circumference (WC), body mass index (BMI), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-C). Kidney stones and recurrence of kidney stones were obtained from questionnaire interview data. We used multivariate logistic regression analysis to explore the correlation between VAI and the risk of kidney stone and kidney stone recurrence. In addition, we performed subgroup analysis, interaction tests, and restricted cubic spline (RCS) analysis. Results A total of 9886 participants were included in this study, with a prevalence of 9.24% for kidney stones and 2.97% for recurrence of kidney stones. The prevalence of kidney stones and kidney stone recurrence increased with higher quartiles of VAI. We observed a significantly positive correlation between VAI and the risk of kidney stone and kidney stone recurrence. Participants with the highest VAI quartiles had a 48% (OR: 1.48, 95%CI: 1.08–2.02) and 52% (OR: 1.52, 95%CI: 0.86–2.71) increased risk of kidney stones and kidney stone recurrence, respectively, compared to participants with the lowest VAI quartiles. Subgroup analysis and interaction tests demonstrated this positive association independent of different subgroup factors. Conclusion Visceral fat accumulation may be associated with an increased risk of kidney stones and kidney stone recurrence.

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“…The accumulation of neutral lipids in non-adipose tissues can lead to various types of cell and organ damage, which in turn can lead to a variety of chronic diseases [10], including oxalate nephropathy [34][35][36][37]. The general pathogenic mechanism of lipotoxicity is thought to be an overload of intracellular free fatty acids, leading to an accumulation of intracellular triglycerides, which increases the production of ROS, apoptosis, or secretion or a combination of profibrogenic and proinflammatory factors [9,10].…”

Section: Discussionmentioning

confidence: 99%

Hydroxycitric acid inhibits oxalate nephropathies formation through crystallization regulation and activation of the PPARα pathway

Zhang

et al. 2022

Preprint

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Oxalate-induced nephropathies comprise a range of kidney disorders, for which there are no efficient pharmacological treatments. Hydroxycitric acid (HCA) is a derivative of citric acid with a variety of pharmacological activities including reducing body weight and calcium salt deposition. However, the specific mechanism of inhibition of oxalate nephropathies by this compound is not well understood. In this study, we successfully applied bioinformatics-based and simulated drug molecular docking approaches to predict potential targets of HCA. Subsequently, we explored the molecular mechanisms of HCA inhibition of renal calcium oxalate (CaOx) deposition and nephrotoxicity in an oxalate-induced NRK-52E cell model and an oxalate nephropathy rat model. HCA could effectively inhibit CaOx crystal deposition and reduce crystal adhesion and oxidative damage, effectively inhibit lipid deposition caused by high oxalate, and reduce lipid nephrotoxicity. HCA is more effective than traditional stone medications in inhibiting CaOx deposition and kidney damage. Further cellular transcriptomic analysis and in vitro results showed that HCA could stably bind peroxisome proliferator-activated receptor α (PPARα) and promote PPARα-RXR heterodimer formation, thus promoting the expression of downstream oxidative stress molecules (Nrf2, HO-1, SOD) and inhibiting calcium ion release and mitochondrial dysfunction, thus reducing oxalate-induced renal lipid peroxidation damage. Therefore, HCA, a novel drug with the ability to modulate lipid metabolism and inhibit CaOx formation, may be a therapeutic option for the treatment of oxalate nephropathies.

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Atorvastatin Decreases Renal Calcium Oxalate Stone Deposits by Enhancing Renal Osteopontin Expression in Hyperoxaluric Stone-Forming Rats Fed a High-Fat Diet

Cited by 7 publications

References 40 publications

Clinical Lipid Metabolism Correlates with Urinary Calculus: TyG Index Has a Closer Correlation

Clinical Lipid Metabolism Correlates with Urinary Calculus: TyG Index Has a Closer Correlation

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

Hydroxycitric acid inhibits oxalate nephropathies formation through crystallization regulation and activation of the PPARα pathway

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