ATP and Adenosine in the Retina and Retinal Diseases

Ye, Shan-Shan; Tang, Yong; Song, Jiantao

doi:10.3389/fphar.2021.654445

Cited by 22 publications

(13 citation statements)

References 67 publications

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“…Under pathological conditions, such as elevated intraocular pressure in glaucoma, P2 × 7R is upregulated, causing retinal neuronal damage. The P2 × 7R antagonists, BBG and MRS2540, prevent neuronal death induced by age-related macular degeneration, glaucoma, and diabetic retinopathy [ 80 ]. In addition to causing tissue damage under pathological conditions, P2 × 7R also plays other roles in the nervous system.…”

Section: P2 × 7r: Distribution and Role In The Nervous Systemmentioning

confidence: 99%

Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties

Hu,

Luo,

Zhu

et al. 2023

Cell Biosci

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Neurodegenerative diseases seriously affect patients’ physical and mental health, reduce their quality of life, and impose a heavy burden on society. However, their treatment remains challenging. Therefore, exploring factors potentially related to the pathogenesis of neurodegenerative diseases and improving their diagnosis and treatment are urgently needed. Recent studies have shown that P2 × 7R plays a crucial role in regulating neurodegenerative diseases caused by neuroinflammation. P2 × 7R is an adenosine 5′-triphosphate ligand-gated cation channel receptor present in most tissues of the human body. An increase in P2 × 7R levels can affect the progression of neurodegenerative diseases, and the inhibition of P2 × 7R can alleviate neurodegenerative diseases. In this review, we comprehensively describe the biological characteristics (structure, distribution, and function) of this gene, focusing on its potential association with neurodegenerative diseases, and we discuss the pharmacological effects of drugs (P2 × 7R inhibitors) used to treat neurodegenerative diseases.

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Section: P2 × 7r: Distribution and Role In The Nervous Systemmentioning

confidence: 99%

Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties

Hu,

Luo,

Zhu

et al. 2023

Cell Biosci

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“…Actually, pharmacological treatments have been utilized in the potential treatment of ophthalmic diseases. Antagonists of P2X7 receptors prevented ATP-induced neuronal apoptosis in glaucoma, DR, and age-related macular degeneration (AMD); the A 1 receptor agonists lowered intraocular pressure in glaucoma; the A 2A receptor agonists or antagonists reduced neuroinflammation in glaucoma, DR, and AMD; the A 3 receptor agonists protected retinal ganglion cells (RGCs) from apoptosis in glaucoma [96]. Since the A 1 , A 2A , and A 3 receptor were concerned in ophthalmic diseases, and it should be taken into consideration that whether this purinergic signalling was modulated by miRNAs or not.…”

Section: Purinergic Signalling Modulated By Mirnas In Ophthalmic Diseasesmentioning

confidence: 99%

MicroRNA: Crucial modulator in purinergic signalling involved diseases

Guo

Yang

et al. 2022

Purinergic Signalling

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Both microRNAs (miRNAs) and purinergic signalling are widely and respectively expressed in various tissues of different organisms and play vital roles in a variety of physiological and pathological processes. Here, we reviewed the current publications contributed to the relationship of miRNAs and purinergic signalling in cardiovascular diseases, gastrointestinal diseases, neurological diseases, and ophthalmic diseases. We tried to decode the miRNAs-purinergic signalling network of purinergic signalling involved diseases. The evidence indicated that more than 30 miRNAs (miR-22, miR-30, miR-146, miR-150, miR-155, miR-187, etc.) directly or indirectly modulate P1 receptors (A1, A2A, A2B, A3), P2 receptors (P2X1, P2X3, P2X4, P2X7, P2Y2, P2Y6, P2Y12), and ecto-enzymes (CD39, CD73, ADA2); P2X7 and CD73 could be modulated by multiple miRNAs (P2X7: miR-21, miR-22, miR-30, miR-135a, miR-150, miR-186, miR-187, miR-216b; CD73: miR-141, miR-101, miR-193b, miR-340, miR-187, miR-30, miR-422a); miR-187 would be the common miRNA to modulate P2X7 and CD73.

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“…However, in neurodegenerative diseases, purinergic signaling becomes dysregulated, and significant amounts of various purine nucleotides are released into the extracellular matrix [ 151 ]. These purine nucleotides are also potent extracellular signaling molecules that can induce purinergic signaling pathways via activation of purinoceptors P1 and P2 that elicit a variety of pathophysiological pathways in the retina contributing to three types of blinding diseases including AMD, diabetic retinopathy, and glaucoma [ 152 ]. Recent studies identified a special sub-type of macrophages, capillary-associated microglia, which through P2Y purinoceptors regulate neurovascular structure and function [ 153 ].…”

Section: Choriocapillaris In Early Amdmentioning

confidence: 99%

Microbiota mitochondria disorders as hubs for early age-related macular degeneration

Fehér¹,

Élő

István

et al. 2022

GeroScience

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Age-related macular degeneration (AMD) is a progressive neurodegenerative disease affecting the central area (macula lutea) of the retina. Research on the pathogenic mechanism of AMD showed complex cellular contribution governed by such risk factors as aging, genetic predisposition, diet, and lifestyle. Recent studies suggested that microbiota is a transducer and a modifier of risk factors for neurodegenerative diseases, and mitochondria may be one of the intracellular targets of microbial signaling molecules. This review explores studies supporting a new concept on the contribution of microbiota—mitochondria disorders to AMD. We discuss metabolic, vascular, immune, and neuronal mechanism in AMD as well as key alterations of photoreceptor cells, retinal pigment epithelium (RPE), Bruch’s membrane, choriocapillaris endothelial, immune, and neuronal cells. Special attention was paid to alterations of mitochondria contact sites (MCSs), an organelle network of mitochondria, endoplasmic reticulum, lipid droplets (LDs), and peroxisomes being documented based on our own electron microscopic findings from surgically removed human eyes. Morphometry of Bruch’s membrane lipids and proteoglycans has also been performed in early AMD and aged controls. Microbial metabolites (short-chain fatty acids, polyphenols, and secondary bile acids) and microbial compounds (lipopolysaccharide, peptidoglycan, and bacterial DNA)—now called postbiotics—in addition to local effects on resident microbiota and mucous membrane, regulate systemic metabolic, vascular, immune, and neuronal mechanisms in normal conditions and in various common diseases. We also discuss their antioxidant, anti-inflammatory, and metabolic effects as well as experimental and clinical observations on regulating the main processes of photoreceptor renewal, mitophagy, and autophagy in early AMD. These findings support an emerging concept that microbiota-mitochondria disorders may be a crucial pathogenic mechanism of early AMD; and similarly, to other age-related neurodegenerative diseases, new treatment approaches should be targeted at these disorders.

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ATP and Adenosine in the Retina and Retinal Diseases

Cited by 22 publications

References 67 publications

Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties

Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties

MicroRNA: Crucial modulator in purinergic signalling involved diseases

Microbiota mitochondria disorders as hubs for early age-related macular degeneration

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