ATP/Hyals dually responsive core-shell hyaluronan/chitosan-based drug nanocarrier for potential application in breast cancer therapy

Li, Huaqiang; Zhuang, Shuqiang; Yang, Yang; Zhou, Fei; Rong, Jianhua; Zhao, Jianhao

doi:10.1016/j.ijbiomac.2021.05.020

Cited by 18 publications

(7 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Typically, most glucose-dependent smart delivery systems utilize glucose oxidase to convert the initial glucose input into other different stimulus outputs in the form of pH reduction (i.e., gluconate production) and ROS production (i.e., hydrogen peroxide production). In recent years, the researchers developed an [68] Copyright 2021, Elsevier. b) The MMPs-cleavable peptide modified core-shell vehicle.…”

Section: Glucose-responsive Drug-releasementioning

confidence: 99%

“…[ 66,67 ] In a report, the development of a dual‐responsive adenosine triphosphate (ATP)/ hyaluronic acid (Hyals)/ CS‐based core–shell drug nanocarrier has been fabricated. [ 68 ] The cores consisted of 3‐fluoro‐4‐carboxyphenylboronic acid‐conjugated quaternary ammonium HA NPs (SNX@HTCC‐FPBA NPs) and crosslinked polyethylene glycol‐methacrylate‐modified hyaluronic acid (mHA‐PEG). Not surprisingly, under identical conditions of 4.0 m m ATP, the SNX release after 48 h was ≈50% without Hyals (0 m m ) and 88% with 4.0 m m Hyals.…”

Section: Stimulus‐responsive Core–shell Structured Nanocarriers For D...mentioning

confidence: 99%

Section: Stimulus‐responsive Core–shell Structured Nanocarriers For D...mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Tailored Drug Delivery Platforms: Stimulus‐Responsive Core–Shell Structured Nanocarriers

Shi,

Zhang,

Zhu

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Core‐shell structured nanocarriers have come into the scientific spotlight in recent years due to their intriguing properties and wide applications in materials chemistry, biology, and biomedicine. Tailored core‐shell structures to achieve desired performances has emerged as a research frontier in the development of smart drug delivery system. However, a systematic review on the design and loading/release mechanisms of stimulus‐responsive core‐shell structured nanocarriers is seldom available. This review starts with the categories of core‐shell structured nanocarriers with different means of drug payload, and then highlights the controlled release mechanism realized through stimulus‐response processes triggered under different environments. Finally, some multifaceted perspectives on the design of core‐shell structured materials as drug carriers are addressed. We hope this review could provide new enlightenments and prospects in the drug delivery field for further developing advanced and smart nanocarriers.This article is protected by copyright. All rights reserved

show abstract

Section: Glucose-responsive Drug-releasementioning

confidence: 99%

Section: Stimulus‐responsive Core–shell Structured Nanocarriers For D...mentioning

confidence: 99%

See 2 more Smart Citations

Tailored Drug Delivery Platforms: Stimulus‐Responsive Core–Shell Structured Nanocarriers

Shi,

Zhang,

Zhu

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…17 HTCC and HA can be self-assembled to form a pH-responsive copolymeric matrix of the microspheres by the electrostatic interaction between amino groups of HTCC with carboxyl groups of HA. 18 Besides, the fabricated HHPMs can also be hydrolyzed by the relatively high HAase concentration in the IME. Thus, HHPMs can specifically release AgNPs, responding to the bacterial infection microenvironment.…”

mentioning

confidence: 99%

Bacterial infection microenvironment‐responsive porous microspheres by microfluidics for promoting anti‐infective therapy

Gao

2022

Smart Medicine

117

View full text Add to dashboard Cite

The overuse of antibiotics for treating bacterial infection has caused severe bacterial resistance and become a public health threat worldwide. It is desired to develop novel antibiotic delivery systems as efficient antibacterial strategies for promoting anti‐infective therapy. Herein, the AgNPs‐loaded N‐[(2‐hydroxy‐3‐trimethyl ammonium) propyl] chitosan (HTCC)/hyaluronic acid (HA) porous microspheres (HHPMs) by microfluidics have been developed as novel bacterial infection microenvironment (IME)‐responsive antibiotic delivery systems for promoting antimicrobial therapy. The release of AgNPs can respond explicitly to the IME with acidic pH values and relatively high hyaluronidase concentration. The unique porous structures of HHPMs can effectively facilitate the capture and enrichment of bacteria, thus exerting synergistic antibacterial effects, which can be more efficient in instant bacteria inhibiting and killing. The excellent biocompatibility of HHPMs is revealed by investigating their hemolytic activity and cytotoxicity. In vivo assays demonstrate that the fabricated AgNPs‐loaded HHPMs can effectively resist bacterial infection and promote wound healing and tissue regeneration at infected wound sites by inhibition of the bacterial survival. This work indicates that fabricated HHPMs are ideal bacterial infection microenvironment‐responsive materials for antibiotic delivery and show great promises for promoting anti‐infective therapy in clinics.

show abstract

Recent Innovations in the Strategies for the Functionalization of Chitosan, Pectin, Alginate, Hyaluronic Acid, Dextran and Inulin Biomaterials for Anticancer Applications-A Review

Ganie

Rather²,

Li³

2022

J Polym Environ

View full text Add to dashboard Cite

ATP/Hyals dually responsive core-shell hyaluronan/chitosan-based drug nanocarrier for potential application in breast cancer therapy

Cited by 18 publications

References 69 publications

Tailored Drug Delivery Platforms: Stimulus‐Responsive Core–Shell Structured Nanocarriers

Tailored Drug Delivery Platforms: Stimulus‐Responsive Core–Shell Structured Nanocarriers

Bacterial infection microenvironment‐responsive porous microspheres by microfluidics for promoting anti‐infective therapy

Recent Innovations in the Strategies for the Functionalization of Chitosan, Pectin, Alginate, Hyaluronic Acid, Dextran and Inulin Biomaterials for Anticancer Applications-A Review

Contact Info

Product

Resources

About