ATP4a Is Required for Wnt-Dependent Foxj1 Expression and Leftward Flow in Xenopus Left-Right Development

Walentek, Peter; Beyer, Tina; Thumberger, Thomas; Schweickert, Axel; Blum, Martin

doi:10.1016/j.celrep.2012.03.005

Cited by 78 publications

(108 citation statements)

References 69 publications

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“…Because Wnt signalling is known to be important for head formation 38 , there may be a link between ERK7 and Wnt signalling. Interestingly, FoxJ1 expression has been shown to be regulated by canonical Wnt signalling 39,40 . Thus, a canonical Wnt signalling pathway may regulate ERK7 expression levels through FoxJ1.…”

Section: Discussionmentioning

confidence: 99%

ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled

et al. 2015

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Cilia are essential for embryogenesis and maintenance of homeostasis, but little is known about the signalling pathways that regulate ciliogenesis. Here, we identify ERK7, an atypical mitogen-activated protein kinase, as a key regulator of ciliogenesis. ERK7 is strongly expressed in ciliated tissues of Xenopus embryos. ERK7 knockdown markedly diminishes both the number and the length of cilia in multiciliated cells, and it inhibits the apical migration of basal bodies. Moreover, ERK7 knockdown results in a loss of the apical actin meshwork, which is required for the proper migration of basal bodies. We find that the actin regulator CapZIP, which has been shown to regulate ciliogenesis in a phosphorylation-dependent manner, is an ERK7 substrate, and that Dishevelled, which has also been shown to regulate ciliogenesis, facilitates ERK7 phosphorylation of CapZIP through binding to both ERK7 and CapZIP. Collectively, these results identify an ERK7/Dishevelled/CapZIP axis that regulates ciliogenesis.

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Section: Discussionmentioning

confidence: 99%

ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled

et al. 2015

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“…Moreover, in multiple tissues in the zebrafish, WNT signaling seems to act downstream of the FGF pathway to directly control foxj1 expression through TCF/LEF transcription factor-binding sites within the foxj1 promoter (Caron et al, 2012). This relationship between WNT signaling and Foxj1 expression is conserved in the Xenopus GRP (Walentek et al, 2012). Besides the HH, FGF and WNT pathways, NOTCH signaling has also been heavily linked to motile cilia differentiation.…”

Section: Signaling Pathways Regulating Ciliary Diversitymentioning

confidence: 99%

Switching on cilia: transcriptional networks regulating ciliogenesis

et al. 2014

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Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory hubs for a variety of signal transduction pathways. Despite having a conserved basic morphology, cilia vary extensively in their shapes and sizes, ultrastructural details, numbers per cell, motility patterns and sensory capabilities. Emerging evidence indicates that this diversity, which is intimately linked to the different functions that cilia perform, is in large part programmed at the transcriptional level. Here, we review our understanding of the transcriptional control of ciliary biogenesis, highlighting the activities of FOXJ1 and the RFX family of transcriptional regulators. In addition, we examine how a number of signaling pathways, and lineage and cell fate determinants can induce and modulate ciliogenic programs to bring about the differentiation of distinct cilia types.

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“…It is possible that early developmental events generate LR positional information that can be used to guide ciliated cells as they develop into a functional LRO or to completely bypass the requirement for cilia [93,94]. Several connections have been made between molecules involved in early LR events and the development of the LRO: Syndecan 2 [95] and the vacuolar-type H þ -ATPase [88,96,97] are involved in the development of normal LRO morphogenesis and cilia formation in zebrafish, and H þ / K þ -ATPase activity [98] and serotonin [99] are needed for Wnt signalling pathways that control LRO development and ciliogenesis in frog embryos. One outstanding question is whether precursor cells receive laterality cues prior to forming the LRO.…”

Section: (C) Laterality Cues For Cilia?mentioning

confidence: 99%

Cilia in vertebrate left–right patterning

Dasgupta

Amack

2016

Phil. Trans. R. Soc. B

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One contribution of 17 to a theme issue 'Provocative questions in left -right asymmetry'. Understanding how left-right (LR) asymmetry is generated in vertebrate embryos is an important problem in developmental biology. In humans, a failure to align the left and right sides of cardiovascular and/or gastrointestinal systems often results in birth defects. Evidence from patients and animal models has implicated cilia in the process of left-right patterning. Here, we review the proposed functions for cilia in establishing LR asymmetry, which include creating transient leftward fluid flows in an embryonic 'left -right organizer'. These flows direct asymmetric activation of a conserved Nodal (TGFb) signalling pathway that guides asymmetric morphogenesis of developing organs. We discuss the leading hypotheses for how cilia-generated asymmetric fluid flows are translated into asymmetric molecular signals. We also discuss emerging mechanisms that control the subcellular positioning of cilia and the cellular architecture of the left-right organizer, both of which are critical for effective cilia function during left-right patterning. Finally, using mosaic cell-labelling and timelapse imaging in the zebrafish embryo, we provide new evidence that precursor cells maintain their relative positions as they give rise to the ciliated left -right organizer. This suggests the possibility that these cells acquire left-right positional information prior to the appearance of cilia.This article is part of the themed issue 'Provocative questions in leftright asymmetry'.

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ATP4a Is Required for Wnt-Dependent Foxj1 Expression and Leftward Flow in Xenopus Left-Right Development

Cited by 78 publications

References 69 publications

ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled

ERK7 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled

Switching on cilia: transcriptional networks regulating ciliogenesis

Cilia in vertebrate left–right patterning

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