ATR prevents Ca
            <sup>2+</sup>
            overload‐induced necrotic cell death through phosphorylation‐mediated inactivation of PARP1 without DNA damage signaling

Li, Zhengke; Wang-Heaton, Hui; Cartwright, Brian M.; Makinwa, Yetunde; Hilton, Benjamin; Musich, Phillip R.; Shkriabai, Nikolozi; Kvaratskhelia, Mamuka; Guan, Shengheng; Chen, Qian; Yu, Xiaochun; Zou, Yue

doi:10.1096/fj.202001636rrr

Cited by 3 publications

(1 citation statement)

References 104 publications

(285 reference statements)

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“…An ssDNA and RPA-independent role for ATR at the nuclear envelope in response to mechanical forces has been reported ( Kumar et al., 2014 ). More recently, suppression of necrotic cell death caused by Ca 2+ overload associated with ischemia has also been reported as another non-canonical and CHK1-independent function for ATR ( Li et al., 2021 ). It is possible that further replication stress and DNA damage-independent functions for ATR remain to be discovered.…”

Section: Discussionmentioning

confidence: 99%

A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

et al. 2022

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Section: Discussionmentioning

confidence: 99%

A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

et al. 2022

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Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia

Kang

Kim

et al. 2022

Pharmacol. Rep

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Targeting B4GALT7 suppresses the proliferation, migration and invasion of hepatocellular carcinoma through the Cdc2/CyclinB1 and miR-338-3p/MMP2 pathway

Liu,

Jia,

Zhao

et al. 2023

PeerJ

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Background As a three-dimensional network involving glycosaminoglycans (GAGs), proteoglycans (PGs) and other glycoproteins, the role of extracellular matrix (ECM) in tumorigenesis is well revealed. Abnormal glycosylation in liver cancer is correlated with tumorigenesis and chemoresistance. However, the role of galactosyltransferase in HCC (hepatocellular carcinoma) is largely unknown. Methods Here, the oncogenic functions of B4GALT7 (beta-1,4-galactosyltransferase 7) were identified in HCC by a panel of in vitro experiments, including MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), colony formation, transwell and flow cytometry assay. The expression of B4GALT7 in HCC cell lines and tissues were examined by qPCR (real-time quantitative polymerase chain reaction) and western blot assay. The binding between B4GALT7 and miR-338-3p was examined by dual-luciferase reporter assay. Results B4GALT7 encodes galactosyltransferase I and it is highly expressed in HCC cells and human HCC tissues compared with para-tumor specimens. MiR-338-3p was identified to bind the 3′ UTR (untranslated region) of B4GALT7. Highly expressed miR-338-3p suppressed HCC cell invasive abilities and rescued the tumor-promoting effect of B4GALT7 in HCC. ShRNA (short hairpin RNA) mediated B4GALT7 suppression reduced HCC cell invasive abilities, and inhibited the expression of MMP-2 and Erk signaling. Conclusion These findings identified B4GALT7 as a potential prognostic biomarker and therapeutic target for HCC.

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ATR prevents Ca ²⁺ overload‐induced necrotic cell death through phosphorylation‐mediated inactivation of PARP1 without DNA damage signaling

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 3 publications

References 104 publications

A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia

Targeting B4GALT7 suppresses the proliferation, migration and invasion of hepatocellular carcinoma through the Cdc2/CyclinB1 and miR-338-3p/MMP2 pathway

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ATR prevents Ca 2+ overload‐induced necrotic cell death through phosphorylation‐mediated inactivation of PARP1 without DNA damage signaling

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 3 publications

References 104 publications

A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia

Targeting B4GALT7 suppresses the proliferation, migration and invasion of hepatocellular carcinoma through the Cdc2/CyclinB1 and miR-338-3p/MMP2 pathway

Contact Info

Product

Resources

About

ATR prevents Ca ²⁺ overload‐induced necrotic cell death through phosphorylation‐mediated inactivation of PARP1 without DNA damage signaling