ATR signaling in mammalian meiosis: From upstream scaffolds to downstream signaling

Pereira, Catalina; Smolka, Marcus B.; Weiss, Robert S.; Brieño‐Enríquez, Miguel A.

doi:10.1002/em.22401

Cited by 28 publications

(28 citation statements)

References 165 publications

(216 reference statements)

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“…The creation of a wait signal is often referred to as a checkpoint ( Hartwell and Weinert, 1989 ). Many of the known dependent relationships in meiotic prophase are established by a core kinase signaling network, consisting of the DNA-damage sensor kinases ATM and ATR and the transducer kinase CHK2 ( Pereira et al, 2020 ). ATM and ATR sense protein-linked DNA ends and RPA-coated single-stranded DNA, respectively ( Marechal and Zou, 2013 ; Awasthi et al, 2015 ).…”

Section: Functions Of Phosphorylationmentioning

confidence: 99%

Phospho-Regulation of Meiotic Prophase

Kar

Hochwagen

2021

Front. Cell Dev. Biol.

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Germ cells undergoing meiosis rely on an intricate network of surveillance mechanisms that govern the production of euploid gametes for successful sexual reproduction. These surveillance mechanisms are particularly crucial during meiotic prophase, when cells execute a highly orchestrated program of chromosome morphogenesis and recombination, which must be integrated with the meiotic cell division machinery to ensure the safe execution of meiosis. Dynamic protein phosphorylation, controlled by kinases and phosphatases, has emerged as one of the main signaling routes for providing readout and regulation of chromosomal and cellular behavior throughout meiotic prophase. In this review, we discuss common principles and provide detailed examples of how these phosphorylation events are employed to ensure faithful passage of chromosomes from one generation to the next.

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Section: Functions Of Phosphorylationmentioning

confidence: 99%

Phospho-Regulation of Meiotic Prophase

Kar

Hochwagen

2021

Front. Cell Dev. Biol.

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“…CDC7, CCNA2, CCNB2, ATR, and BUB1B are also genes related to cell cycle progression [26][27][28]. (Pereira, et al, 2020;Yamada, et al, 2014)In this experiment, the expression levels of CDK1, CDC7, CCNA2, BUB1B in the glucose overfeeding group were the highest (Supplement materialsS-Fig. 3).…”

Section: Discussionmentioning

confidence: 61%

“…In this experiment, the gene expression of CDK1 was signi cantly increased in the overfeeding group, especially the glucose overfeeding group, indicating that glucose promoted the mitosis of hepatocytes and induced the proliferation and meristem of hepatocytes. CDC7, CCNA2, CCNB2, ATR, and BUB1B are also genes related to cell cycle progression [26][27][28]. (Pereira, et al, 2020;Yamada, et al, 2014)In this experiment, the expression levels of CDK1, CDC7, CCNA2, BUB1B in the glucose overfeeding group were the highest (Supplement materialsS-Fig.…”

Section: Discussionmentioning

confidence: 64%

Study on The Effect of Different Type of Sugar on Lipid Deposition in Goose Fatty Liver

Wei¹,

Deng²,

Teng³

et al. 2021

Preprint

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Backgroud: Early research in our lab is indicated that the effect of glucose, fructose and sucrose on the levels of triacylglycerol and inflammatory factor was significantly different, and it is speculated that the regulatory mechanism of lipid deposition by different type of sugar in the liver is different. Methods: In order to explore lipid deposition difference mediated by different type of sugar (glucos, fructose and sucrose) in goose fatty liver formation, this experiment was performed from cell culture, overfeeding experiment and transcriptome analysis three level. Results: Cell culture experiment results indicated that the levels of intracellular triglyceride (TG), total cholesterol (T-CHO) and lipid content of fructose treatment and sucrose treatment were significantly higher than those of glucose treatment (P < 0.05). In slaughter performance, the liver weight, the ratio of liver weight to body weight, feed conversion ratio (liver weight / feed consumption ) were better in sucrose overfeeding group (P < 0.05). In addition, the liver of the sucrose overfeeding group contained a lot of unsaturated fatty acids, especially (n-3) polyunsaturated fatty acids (n-3 PUFA ) (P < 0.05). Transcriptome analysis shown that the PPAR signaling pathway is highly enriched in the fructose and sucrose overfeeding groups; cell cycle and DNA replication pathways were highly enriched in the glucose overfeeding group. Conclusions: Due to lipids outward transportation decrease and anti-imflammation of unsaturated fatty acids (UFA), thereby, fructose and sucrose hve better ability to induce steatosis in foie gras formation.

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“…COs are stabilized by cohesin rings encompassing the sister chromatids distal to these sites on the chromosome arms ( Petronczki et al, 2003 ). Full literature reviews about these processes have been described ( Handel and Schimenti, 2010 ; Hunter, 2015 ; Gray and Cohen, 2016 ; Pereira et al, 2020 ).…”

Section: Meiosis and Cohesinmentioning

confidence: 99%

Meiotic Cohesin and Variants Associated With Human Reproductive Aging and Disease

Beverley

Snook

Brieño‐Enríquez

2021

Front. Cell Dev. Biol.

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Successful human reproduction relies on the well-orchestrated development of competent gametes through the process of meiosis. The loading of cohesin, a multi-protein complex, is a key event in the initiation of mammalian meiosis. Establishment of sister chromatid cohesion via cohesin rings is essential for ensuring homologous recombination-mediated DNA repair and future proper chromosome segregation. Cohesin proteins loaded during female fetal life are not replenished over time, and therefore are a potential etiology of age-related aneuploidy in oocytes resulting in decreased fecundity and increased infertility and miscarriage rates with advancing maternal age. Herein, we provide a brief overview of meiotic cohesin and summarize the human genetic studies which have identified genetic variants of cohesin proteins and the associated reproductive phenotypes including primary ovarian insufficiency, trisomy in offspring, and non-obstructive azoospermia. The association of cohesion defects with cancer predisposition and potential impact on aging are also described. Expansion of genetic testing within clinical medicine, with a focus on cohesin protein-related genes, may provide additional insight to previously unknown etiologies of disorders contributing to gamete exhaustion in females, and infertility and reproductive aging in both men and women.

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ATR signaling in mammalian meiosis: From upstream scaffolds to downstream signaling

Abstract: This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 28 publications

References 165 publications

Phospho-Regulation of Meiotic Prophase

Phospho-Regulation of Meiotic Prophase

Study on The Effect of Different Type of Sugar on Lipid Deposition in Goose Fatty Liver

Meiotic Cohesin and Variants Associated With Human Reproductive Aging and Disease

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