Atractylenolide I inhibits antibiotic-induced dysbiosis of the intestinal microbiome

Liu, Penglin; Zhao, Gang; Zhang, Lize; Yan, Gao; Gu, Yunfei

doi:10.21037/atm-21-4656

Cited by 12 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lipopolysaccharides, also known as endotoxins, enter the blood circulation from the damaged intestinal mucosa and stimulate the release of inflammatory mediators of different cell types ( Maldonado et al, 2016 ), resulting in increased expression of TLR4 and NLRP3 in small intestinal cells ( Xu et al, 2014 ; Qiu et al, 2021 ). The high-altitude environment may affect the intestinal microbiota by regulating TLR4/NF-κB signaling ( Liu P. et al, 2021 ). TLR4 upregulates the expression of IL-23 ( Kang et al, 2018 ), and IL-23 and its downstream target IL-22 are involved in the regulation of the intestinal flora ( Fatkhullina et al, 2018 ).…”

Section: Mechanism Underlying the Plateau Environment-mediated Altera...mentioning

confidence: 99%

Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

Pan

Bai

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

The intestinal microbial community is the largest ecosystem in the human body, in which the intestinal flora plays a dominant role and has a wide range of biological functions. However, it is vulnerable to a variety of factors, and exposure to extreme environments at high altitudes, as seen on the Qinghai–Tibet plateau, may cause changes in the structure and function of the host intestinal flora. Conversely, the intestinal flora can help the host adapt to the plateau environment through a variety of ways. Herein, we review the relationship and underlying mechanism between the host intestinal flora and the plateau environment by discussing the characteristics of the plateau environment, its influence on the intestinal flora, and the important role of the intestinal flora in host adaptation to the plateau environment. This review aimed to provide a reference for maintaining the health of the plateau population.

show abstract

Section: Mechanism Underlying the Plateau Environment-mediated Altera...mentioning

confidence: 99%

Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

Pan

Bai

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Atractylenolide I, a component extracted from Rhizoma Atractylodis macrocephalae, may inhibit dysbacteriosis by regulating TLR4/MyD88/NF-κB signaling 193 . Alpha-galactosylceramide, produced by bacteria such as Bacteroides fragilis, Bacteroides vulgatus, and Prevotella copri, exerts antitumor effects by activating nonconventional T cells, such as invariant natural killer T (iNKT) cells and γδ T cells 194 .…”

Section: Treatments Targeting Kras and The Tmementioning

confidence: 99%

Impact of KRAS mutation on the tumor microenvironment in colorectal cancer

Zhou,

Kuang,

Wang

et al. 2024

Int. J. Biol. Sci.

View full text Add to dashboard Cite

Kirsten rat sarcoma viral oncogene homolog (KRAS) is an oncogene implicated in the pathophysiology of many cancers. Increasing evidence shows that KRAS mutation is correlated with poor prognosis in numerous cancers, including colorectal cancer (CRC), breast cancer, and melanoma. KRAS also participates in regulating the CRC microenvironment. However, the direct and indirect therapeutic targets of KRAS in CRC have not been identified; thus, elucidating the mechanisms and interactions between KRAS and the tumor microenvironment (TME) in-depth is paramount. Herein, we present some of the major roles KRAS plays in shaping the heterogeneity of the TME and propose a potential strategy for targeting the downstream components of the KRAS signaling pathway and the TME in CRC.

show abstract

“…This regulation influences the composition of the intestinal microbiota and ameliorates colonic inflammation ( Qu et al, 2022 ). Moreover, a study comparing changes in the gut microbiota of mice following AT-I treatment, utilizing a mouse model of intestinal dysbiosis, demonstrates that AT-I adjusts the gut microbiota by increasing the abundance of beneficial bacteria such as lactobacilli and bifidobacteria, while dose-dependently reducing the abundance of harmful bacteria like Escherichia coli and Candida ( Liu et al, 2021 ). This work provides more evidence that the gut microbiota mediates the inhibitory effect of AT-Ⅰ on tumor growth, with possible mechanisms involving the downregulation of the TLR4/MyD88/NF-kB signaling pathway.…”

Section: The Pharmacological Activities Of Atsmentioning

confidence: 99%

Molecular targets associated with ulcerative colitis and the benefits of atractylenolides-based therapy

Qian,

Ye,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Ulcerative colitis (UC) is a chronic inflammatory disease of the intestines that can significantly impact quality of life and lead to various complications. Currently, 5-aminosalicylic acid derivatives, corticosteroids, immunosuppressants, and biologics are the major treatment strategies for UC, but their limitations have raised concerns. Atractylenolides (ATs), sesquiterpene metabolites found in Atractylodes macrocephala Koidz., have shown promising effects in treating UC by exerting immune barrier modulation, alleviating oxidative stress, gut microbiota regulation, improving mitochondrial dysfunction and repairing the intestinal barrier. Furthermore, ATs have been shown to possess remarkable anti-fibrosis, anti-thrombus, anti-angiogenesis and anti-cancer. These findings suggest that ATs hold important potential in treating UC and its complications. Therefore, this review systematically summarizes the efficacy and potential mechanisms of ATs in treating UC and its complications, providing the latest insights for further research and clinical applications.

show abstract

Atractylenolide I inhibits antibiotic-induced dysbiosis of the intestinal microbiome

Cited by 12 publications

References 24 publications

Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

Review of the relationship and underlying mechanisms between the Qinghai–Tibet plateau and host intestinal flora

Impact of KRAS mutation on the tumor microenvironment in colorectal cancer

Molecular targets associated with ulcerative colitis and the benefits of atractylenolides-based therapy

Contact Info

Product

Resources

About