Atrial fibrillation and atrial cardiomyopathies

Baman, Jayson R.; Cox, James L.; McCarthy, Patrick M.; Kim, Daniel; Patel, Ravi B.; Passman, Rod; Wilcox, Jane E.

doi:10.1111/jce.15083

Cited by 9 publications

(3 citation statements)

References 103 publications

(159 reference statements)

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“…The ectopic impulse theory of atrial fibrillation, the single-loop reentry theory, and the multiwavelet reentry theory are cornerstones for understanding the mechanisms of the occurrence and maintenance of atrial fibrillation, which increase the risk of ischemic stroke, systemic embolism, heart failure, and mortality [ 1 ]. Electrical and structural remodeling plays an important role in the pathophysiology of the development of atrial fibrillation.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] MIP‐1α Level and Its Correlation with the Risk of Left Atrial Remodeling in Patients with Atrial Fibrillation

Bai

Zhao

et al. 2022

Contrast Media & Molecular Imaging

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The aim of this study is to investigate the expression level of macrophage inflammatory protein-1α (MIP-1α) in atrial fibrillation patients and its correlation with the risk of left atrial remodeling. A total of 64 atrial fibrillation patients admitted to our hospital from April 2020 to December 2021 were prospectively selected as the case group and 61 healthy subjects who received physical examination during the same period were selected as the control group. Serum MIP-1α level was determined by a double-antibody sandwich enzyme-linked immunosorbent assay. Serum MIP-1α expression levels were compared between the case and the control groups. The case group was divided into high-level and low-level groups according to the serum MIP-1α median. Simultaneously, the sociodemographic data, clinical data, and left atrial remodeling indexes of the patients were collected in the case group. The Pearson correlation analysis was applied to analyze the correlation between the serum MIP-1α level and the risk of left atrial remodeling in patients with atrial fibrillation. The serum MIP-1α level was significantly higher in the case group than that in the control group ( P < 0.05 ), high-level group (≥2.14 pg/mL, 32 cases), and low-level group (<2.14 pg/mL, 32 cases). There were significant differences in the anteroposterior diameter, upper and lower diameter, left and right diameter of the left atrium, left atrial volume, volume index, left atrial global ejection fraction, and sphericity between the low-level and high-level groups ( P < 0.05 ). The Pearson correlation analysis showed that serum MIP-1α level was positively correlated with the left atrial anteroposterior diameter (r = 0.745), left atrial left and right diameter (r = 0.759), left atrial upper and lower diameter (r = 0.810), left atrial volume (r = 0.837), left atrial volume index (r = 0.813), and left atrial sphericity (r = 0.785) but negatively correlated with the left atrial global ejection fraction (r = -0.731) ( P < 0.05 ). The expression level of serum MIP-1α is high in atrial fibrillation patients and is associated with the risk of left atrial remodeling.

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Section: Introductionmentioning

confidence: 99%

[Retracted] MIP‐1α Level and Its Correlation with the Risk of Left Atrial Remodeling in Patients with Atrial Fibrillation

Bai

Zhao

et al. 2022

Contrast Media & Molecular Imaging

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“…ACM impairs the storage function of the atria and poor ventricular filling. The histological features of ACM are as follows: (1) cardiomyocytic lesions; (2) fibrosis; (3) Myocardial lesions combined with fibrosis; (4) Primary non-collagen infiltration (with or without cardiomyocyte changes) [29]. In atrial remodeling and ACM, atrial fibrosis is an important pathological manifestation of both.…”

Section: Impairment Of Auxiliary Pump and Storage Functionmentioning

confidence: 99%

Atrial Failure: Mechanisms, Diagnosis, and Potential Therapeutic Targets

Li,

Liu,

Yin

et al. 2023

austinjcardiovascdisatherosclerosis

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The normal atrial function includes ventricular systolic storage function, early ventricular diastolic conduit function, and auxiliary pump function in late ventricular diastolic function, which assists in ventricular filling and maintaining cardiac output. Atrial dysfunction can result in or increase cardiac dysfunction, impacting the patient’s quality of life and life expectancy, even in the absence of evident valve or ventricular problems. Atrial failure, which mostly refers to the left atrium, has recently been given new clinical meaning and is being treated as a separate condition [1]. The mechanism, diagnosis, and potential therapeutic targets of atrial failure will be discussed in this article to better comprehend and treat atrial failure in the future.

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“…That is, AF could be only the tip of the iceberg with the associated cardiovascular contributors as the main basis for AF development and progression. 6 While high AF burden itself can alter the atria and co-contribute to the development and progression of atrial cardiomyopathic alterations and consequences, this is less clear for infrequent or short periods of AF.…”

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confidence: 99%