Atrial flutter in patients treated for atrial fibrillation with propafenone

Limitations to antiarrhythmic drug use in patients with atrial fibrillation

“…Of interest, none of the patients taking flecainide had atrial flutter, although 20 (8.5%) patients taking propafenone did, 10 with contraindications and/or warnings and 10 without. 15 Even though CARAF was neither designed nor powered to assess adverse events, we examined the rates of medication discontinuation, pacemaker implantation and bleeding among patients with contraindications and/or warnings and among those without. There were no significant differences with respect to discontinuation of medications; 2% of patients concomitantly taking both warfarin and amiodarone had a bleed (experiencing > 20 g/L drop in hemoglobin levels or requiring a transfusion), compared with 1.6% of patients not taking both drugs.…”

Ablacja cieśni trójdzielno-żylnej wśród pacjentów z przetrwałym migotaniem przedsionków jako terapia pomostowa celem utrzymania rytmu zatokowego — badanie pilotażowe

“…However, the clinical and electrophysiological background underlying the organization of AF into AFL during antiarrhythmic therapy is not fully proved [4,5]. Such evolution was reported in the early 1990s in up to 20% of patients receiving Ic AAD treatment (so-called Ic AAD-AFL) [6]. Hence, providing the beta-adrenolytic treatment in order to avoid 1:1 conduction was necessary.…”

Atrial Flutter, Typical and Atypical: A Review

“…Class IA and IC AADs are relatively ineffective or have no effect [60][61][62][63][64][65] and can be problematic if they cause a slow atrial flutter rate ≤200/min with 1:1 AV conduction and QRS widening that mimics ventricular tachycardia (see Figure 4). 66,67 Amiodarone may not be very effective at re-establishing sinus rhythm in the acute setting but it does help control ventricular rate.…”