Atrial myxomas and different clinical presentations

Messina, Francesco; Romano, Pietro; Crosca, Sergio

doi:10.1016/j.ijcard.2015.08.063

Cited by 3 publications

(5 citation statements)

References 21 publications

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“…En la mayoría de los pacientes hay uno o más signos pertenecientes a la tríada clásica, que incluye manifestaciones obstructivas, embólicas y constitucionales. (1,2) La presentación como insuficiencia cardíaca aguda en pacientes con mixoma auricular es poco frecuente. Varios mecanismos patogénicos se han propuesto.…”

Section: Discussionunclassified

“…La cirugía debe ser urgente, para mejorar la evolución clínica y evitar complicaciones como los fenómenos embólicos o la muerte súbita. (1)(2)(3)(4)(5) En ocasiones es necesario la intervención quirúrgica de la válvula mitral si existe dilatación del anillo o están afectados los velos o las cuerdas por el tumor. 6…”

Section: Discussionunclassified

“…Afectan a todos los grupos etarios y a ambos sexos, pero con predominancia en mujeres. Los síntomas varían y la presentación clínica suele ser progresiva y está relacionada con el tamaño y la localización del tumor (1) . Cuando se encuentra en la aurícula izquierda, además de las manifestaciones clásicas, incluyen trastornos de la conducción y obstrucción valvular generando signos y síntomas de insuficiencia cardiaca.…”

Section: Introductionunclassified

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Mixoma cardiaco gigante como causa de insuficiencia cardiaca aguda.

Perez¹,

Blanco²,

Montero³

et al. 2019

Rev. méd. (Col. Méd. Cir. Guatem.)

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Resumen: Los mixomas son los tumores cardiacos primarios más frecuentes. Los síntomas varían y la presentación clínica suele ser progresiva y está relacionada con el tamaño y la localización del tumor. Nosotros describimos el caso de un paciente que presentó insuficiencia cardiaca severa refractaría al tratamiento médico como manifestación de un mixoma cardíaco gigante y que requirió cirugía de urgencia.

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Section: Discussionunclassified

Section: Introductionunclassified

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Mixoma cardiaco gigante como causa de insuficiencia cardiaca aguda.

Perez¹,

Blanco²,

Montero³

et al. 2019

Rev. méd. (Col. Méd. Cir. Guatem.)

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“…3,4 Clinical presentation may vary greatly, ranging from nonspecific cardiac symptoms (dyspnea, palpitations) to generic symptoms (fever, weight loss, fatigue) or embolic events. 5,6 Cardiac symptoms are usually progressive and related to tumor size. 7 Acute heart failure in patients with atrial myxoma has rarely been described, and several pathogenetic mechanisms have been proposed.…”

Section: Discussionmentioning

confidence: 99%

Acute heart failure related to a large left atrial myxoma

Chiariello

Bruno

Colizzi

et al. 2018

Baylor University Medical Center Proceedings

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An association between atrial myxoma and left ventricular failure is rarely described, is not completely understood, and may have multiple etiologies. We present a 49-year-old man with no history of cardiovascular disease who was admitted to our hospital with pulmonary edema. He was in atrial fibrillation with rapid ventricular response. Echocardiography showed a 10.5-cm left atrial myxoma, which had been asymptomatic until the onset of congestive heart failure in the presence of severe left ventricular systolic dysfunction. Left ventricular inflow obstruction associated with the giant atrial mass could not be the only cause for acute heart failure.

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“…Recently proteomics studies have led to the characterization of different expression patterns in primary cardiac tumors (PCTs). Amog these atrial myxoma, is the most common tumor and exhibits a heterogeneous phenotype, consisting of adult cells expressing specific protein antigens that are specific to various cell lineages, often within the same tumor, including antigen specific to epithelial, endothelial, myogenic, myofibroblast, neural and neuroendocrine cell lineages [67]. The detection of candidate protein biomarkers for cardiac myxoma is a complex because of the known heterogeneity and their relatively rare incidence; moreover, the use of proteomic profiling to discover biomarkers of for myxoma is still in its infancy.…”

Section: Proteomics In Heart Diseasesmentioning

confidence: 99%

Proteomics and Human Diseases

Lippolis¹,

Angelis²

2016

J Proteomics Bioinform

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Proteomics, the large scale study of proteins and protein variations, contributes to a better understanding of the molecular basis of variability in susceptibility to diseases that are associated with genetic diversity and environmental factors. The development of proteomic technologies has permitted the unprecedented large-scale identification of proteins in any biological system. Human proteomics point out physiological conditions that could greatly impact on medicine. This knowledge has the potential to decode the pathogenic mechanisms underlying diseases, elucidate potential risk factors and molecular targets for drug development and therapeutic interventions and identify promising biomolecules that could be developed for diagnostic and prognostic purposes and for improved disease management strategies. Thus proteomics can translate basic scientific discoveries into the clinical practice for precision medicine. This report provides an overview of targeted proteomics in biomedical clinical science by focusing on current stateof-the-art relatively to advances in biomedical proteomic applications. Future prospective metaproteomics and proteogenomics studies are highlighted.

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Atrial myxomas and different clinical presentations

Cited by 3 publications

References 21 publications

Mixoma cardiaco gigante como causa de insuficiencia cardiaca aguda.

Mixoma cardiaco gigante como causa de insuficiencia cardiaca aguda.

Acute heart failure related to a large left atrial myxoma

Proteomics and Human Diseases

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