Atrial natriuretic peptide and feeding activity patterns in rats

Oliveira, M H A; Antunes‐Rodrigues, José; Gutkowska, Jolanta; Leal, Ângela M. O.; Elias, Lucila Leico Kagohara; Moreira, Ayrton Custódio

doi:10.1590/s0100-879x1997000400006

Cited by 9 publications

(6 citation statements)

References 40 publications

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“…Recently, we demonstrated that the circadian variations in plasma ANP and corticosterone are similar in rats fed ad libitum or on a restricted feeding schedule (18). The disagreement between our previous results of ANP daily variation in rats and the present result in humans suggests a possible physiological difference between species.…”

contrasting

confidence: 92%

Release of plasma atrial natriuretic peptide after volume expansion is not related to pituitary-adrenal axis diurnal variation in normal subjects

Elias¹,

Antunes‐Rodrigues²,

Moreira³

1997

Braz J Med Biol Res

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The existence of a circadian rhythm of atrial natriuretic peptide (ANP) in humans is controversial. We studied the plasma ANP response to isotonic blood volume expansion in the morning and in the afternoon and its relationship with adrenocorticotropic hormone (ACTH)-cortisol diurnal variation in seven normal subjects. Basal plasma ANP level was similar in the morning (19.6 ± 2.4 pg/ml) and in the afternoon (21.8 ± 4.8 pg/ml). The ANP peak obtained with saline infusion (0.9% NaCl, 12 ml/kg) in the morning (49.4 ± 8 pg/ml) did not differ from that obtained in the afternoon (60.3 ± 10.1 pg/ml). There was no correlation between the individual mean cortisol and ACTH levels and the ANP peak obtained with saline infusion. These data indicate no diurnal variation in plasma ANP secretion induced by blood volume expansion and no relationship between plasma ANP peak and ACTH-cortisol diurnal variation.Correspondence

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contrasting

confidence: 92%

Release of plasma atrial natriuretic peptide after volume expansion is not related to pituitary-adrenal axis diurnal variation in normal subjects

Elias¹,

Antunes‐Rodrigues²,

Moreira³

1997

Braz J Med Biol Res

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“…Thus, the inhibition of water intake may be part of a larger, or more general, phenomenon and may not be specific to water intake. Newly emerged evidence showed that ANP also played a role in modulating feeding activity patterns in rats [24]. A study by Tarjan showed intracerebral administration ANP not only inhibited water and salt intake, but reduced food intake, suggesting ANP may centrally inhibit food intake [25].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Dehydration-Induced Water Intake by Glucocorticoids Is Associated with Activation of Hypothalamic Natriuretic Peptide Receptor-A in Rat

et al. 2010

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Atrial natriuretic peptide (ANP) provides a potent defense mechanism against volume overload in mammals. Its primary receptor, natriuretic peptide receptor-A (NPR-A), is localized mostly in the kidney, but also is found in hypothalamic areas involved in body fluid volume regulation. Acute glucocorticoid administration produces potent diuresis and natriuresis, possibly by acting in the renal natriuretic peptide system. However, chronic glucocorticoid administration attenuates renal water and sodium excretion. The precise mechanism underlying this paradoxical phenomenon is unclear. We assume that chronic glucocorticoid administration may activate natriuretic peptide system in hypothalamus, and cause volume depletion by inhibiting dehydration-induced water intake. Volume depletion, in turn, compromises renal water excretion. To test this postulation, we determined the effect of dexamethasone on dehydration-induced water intake and assessed the expression of NPR-A in the hypothalamus. The rats were deprived of water for 24 hours to have dehydrated status. Prior to free access to water, the water-deprived rats were pretreated with dexamethasone or vehicle. Urinary volume and water intake were monitored. We found that dexamethasone pretreatment not only produced potent diuresis, but dramatically inhibited the dehydration-induced water intake. Western blotting analysis showed the expression of NPR-A in the hypothalamus was dramatically upregulated by dexamethasone. Consequently, cyclic guanosine monophosphate (the second messenger for the ANP) content in the hypothalamus was remarkably increased. The inhibitory effect of dexamethasone on water intake presented in a time- and dose-dependent manner, which emerged at least after 18-hour dexamethasone pretreatment. This effect was glucocorticoid receptor (GR) mediated and was abolished by GR antagonist RU486. These results indicated a possible physiologic role for glucocorticoids in the hypothalamic control of water intake and revealed that the glucocorticoids can act centrally, as well as peripherally, to assist in the normalization of extracellular fluid volume.

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“…Along this line of reasoning, it has been demonstrated that ANP release occurs with a pulsatile pattern during the circadian cycle, in which secretory peaks anticipate food ingestion and daily activity (Oliveira et al 1993, 1997). Collectively, the present observations together with previous studies suggest that the increase in the rhythmic activity of 5‐HTergic neurones in DRN appears to modulate renal efferent mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Noradrenergic stimulation within midbrain raphe increases electrolyte excretion in rats

Cedraz-Mercez

Mecawi

Lepletier

et al. 2007

Experimental Physiology

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The present study was carried out to assess the influence of noradrenergic stimulation of the midbrain dorsal (DRN) and median raphe nuclei (MRN) on urinary volume and electrolyte excretion in hydrated rats. Wistar rats were implanted with a guide cannula into the MRN or DRN and then submitted to two intragastric administrations of water in order to attain an increased diuresis. The following treatments were performed.

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Atrial natriuretic peptide and feeding activity patterns in rats

Cited by 9 publications

References 40 publications

Release of plasma atrial natriuretic peptide after volume expansion is not related to pituitary-adrenal axis diurnal variation in normal subjects

Release of plasma atrial natriuretic peptide after volume expansion is not related to pituitary-adrenal axis diurnal variation in normal subjects

Inhibition of Dehydration-Induced Water Intake by Glucocorticoids Is Associated with Activation of Hypothalamic Natriuretic Peptide Receptor-A in Rat

Noradrenergic stimulation within midbrain raphe increases electrolyte excretion in rats

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