Atrial natriuretic peptide (ANP) inhibits DMBA/croton oil induced skin tumor growth by modulating NF-κB, MMPs, and infiltrating mast cells in swiss albino mice

Subramanian, Vimala; Vellaichamy, Elangovan

doi:10.1016/j.ejphar.2014.07.024

Cited by 18 publications

(17 citation statements)

References 50 publications

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“…DMBA is a potent laboratory carcinogen known to produce toxic and highly diffusible ROS, which are capable of producing deleterious effects due to the presence of their thiol epoxide . The present study reported decreased bwt in DMBA‐treated hamsters.…”

Section: Discussionsupporting

confidence: 56%

RETRACTED: Assessment of anticancer activity: A comparison of dose–response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk)

Vaithiyanathan

Mirunalini

2015

Oral Science International

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a b s t r a c tBackground: Oral cancer is the sixth most common malignancy worldwide and is thus an important cause of death and morbidity. Although several drugs have been developed for the treatment of oral cancer, naturally occurring phytochemicals have been recommended by nutritionists and health experts to treat various types of cancer. Pergularia daemia is a well-known herb distributed across India, finding many uses in medicine. Aim: The present study was mainly designed to determine the dose-response effect of the whole plant extract of P. daemia on experimental oral carcinogenesis. Materials and methods: Male golden Syrian hamsters were painted with 0.5% of 7,12dimethylbenz[a]anthracene (DMBA) in liquid paraffin on the left buccal pouch to induce oral cancer, thrice a week for 14 weeks. The anticancer effect of the ethyl acetate and methanolic extracts of P. daemia was observed to be dose dependent (100, 200, and 300 mg/kg body weight (bwt)) by assessing the bwt, tumor incidence, changes in oxidant/antioxidant levels, and histological alterations of control and experimental animals. Results: Our results showed that of the three doses used, the high dose (300 mg/kg bwt) exhibited excellent antioxidant activity in comparison to the other two doses. Moreover, our findings suggest that the methanolic extract significantly inhibited cancer development to a greater extent than the ethyl acetate extract. Conclusion: Thus, it could be concluded that the whole plant of P. daemia presents an easily accessible source of natural antioxidants, and regular consumption can reduce the incidence of oral cancer.

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Section: Discussionsupporting

confidence: 56%

RETRACTED: Assessment of anticancer activity: A comparison of dose–response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk)

Vaithiyanathan

Mirunalini

2015

Oral Science International

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“…Studies have shown that ANP and NPRA are implicated in the promotion or attenuation of cell proliferation and help to maintain cells in stem cell-like state. ANP administration has been reported to decrease or increase cancer cell proliferation both in vivo and in vitro [7,8,44,45], and the apoptosis increases when ANP is added [46]. Despite the controversial role of ANP in cancer progression, the receptor, NPRA is associated with cancer development in esophageal squamous cell carcinomas [11], and the loss of NPRA inhibits cell proliferation and cell viability in several cancer types [12,13].…”

Section: Discussionmentioning

confidence: 99%

Natriuretic peptide receptor A inhibition suppresses gastric cancer development through reactive oxygen species-mediated G2/M cell cycle arrest and cell death

Wang

et al. 2016

Free Radical Biology and Medicine

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“…However, the specific cause of the elevation of natriuretic peptide plasma levels seen in cancer has not been elucidated. In recent years, it has been demonstrated that natriuretic peptides, or compounds with similar activity, decrease the number of several cancer cells in vitro through a reduction of DNA synthesis [ 32 ] and inhibition of c-Fos and c-Jun protooncogenes [ 33 ], inhibit lung metastases and skin carcinogenesis in animal models [ 34 , 35 ], and diminish the expression of vascular endothelial growth factor and that of its receptor VEGFR2, thus having the potential to control vasculogenesis [ 36 ]. One work has shown opposite effects of natriuretic peptides on carcinogenesis depending on their concentrations [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

N-Terminal Pro-Brain Natriuretic Peptide Is Associated with a Future Diagnosis of Cancer in Patients with Coronary Artery Disease

et al. 2015

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ObjectiveSeveral papers have reported elevated plasma levels of natriuretic peptides in patients with a previous diagnosis of cancer. We have explored whether N-terminal pro-brain natriuretic peptide (NT-proBNP) plasma levels predict a future diagnosis of cancer in patients with coronary artery disease (CAD).MethodsWe studied 699 patients with CAD free of cancer. At baseline, NT-proBNP, galectin-3, monocyte chemoattractant protein-1, soluble tumor necrosis factor-like weak inducer of apoptosis, high-sensitivity C-reactive protein, and high-sensitivity cardiac troponin I plasma levels were assessed. The primary outcome was new cancer diagnosis. The secondary outcome was cancer diagnosis, heart failure requiring hospitalization, or death.ResultsAfter 2.15±0.98 years of follow-up, 24 patients developed cancer. They were older (68.5 [61.5, 75.8] vs 60.0 [52.0, 72.0] years; p=0.011), had higher NT-proBNP (302.0 [134.8, 919.8] vs 165.5 [87.4, 407.5] pg/ml; p=0.040) and high-sensitivity C-reactive protein (3.27 [1.33, 5.94] vs 1.92 [0.83, 4.00] mg/L; p=0.030), and lower triglyceride (92.5 [70.5, 132.8] vs 112.0 [82.0, 157.0] mg/dl; p=0.044) plasma levels than those without cancer. NT-proBNP (Hazard Ratio [HR]=1.030; 95% Confidence Interval [CI]=1.008-1.053; p=0.007) and triglyceride levels (HR=0.987; 95%CI=0.975-0.998; p=0.024) were independent predictors of a new cancer diagnosis (multivariate Cox regression analysis). When patients in whom the suspicion of cancer appeared in the first one-hundred days after blood extraction were excluded, NT-proBNP was the only predictor of cancer (HR=1.061; 95%CI=1.034-1.088; p<0.001). NT-proBNP was an independent predictor of cancer, heart failure, or death (HR=1.038; 95%CI=1.023-1.052; p<0.001) along with age, and use of insulin and acenocumarol.ConclusionsNT-proBNP is an independent predictor of malignancies in patients with CAD. New studies in large populations are needed to confirm these findings.

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Atrial natriuretic peptide (ANP) inhibits DMBA/croton oil induced skin tumor growth by modulating NF-κB, MMPs, and infiltrating mast cells in swiss albino mice

Cited by 18 publications

References 50 publications

RETRACTED: Assessment of anticancer activity: A comparison of dose–response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk)

RETRACTED: Assessment of anticancer activity: A comparison of dose–response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk)

Natriuretic peptide receptor A inhibition suppresses gastric cancer development through reactive oxygen species-mediated G2/M cell cycle arrest and cell death

N-Terminal Pro-Brain Natriuretic Peptide Is Associated with a Future Diagnosis of Cancer in Patients with Coronary Artery Disease

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