Attachment chemistry of aromatic compounds on a Silicon(100) surface

Henriksson, Anders; Nishiori, Daiki; Maeda, Hiroaki; Miyachi, Mariko; Yamanoi, Yoshinori; Nishihara, Hiroshi

doi:10.1016/j.susc.2017.11.017

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…In addition, photonic integrated circuit technology (PIC) provides the opportunity for the monolithic integration of electronic and photonic devices, allowing the integration of optical sensors, electrodes, detectors, light-sources, and read-out electronics in a single chip. Furthermore, their implementation as biosensors is facilitated by a plethora of well-established and newly developed chemical functionalization protocols that may be applied to immobilize receptor molecules on silicon surfaces [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

An Approach to Ring Resonator Biosensing Assisted by Dielectrophoresis: Design, Simulation and Fabrication

et al. 2020

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The combination of extreme miniaturization with a high sensitivity and the potential to be integrated in an array form on a chip has made silicon-based photonic microring resonators a very attractive research topic. As biosensors are approaching the nanoscale, analyte mass transfer and bonding kinetics have been ascribed as crucial factors that limit their performance. One solution may be a system that applies dielectrophoretic forces, in addition to microfluidics, to overcome the diffusion limits of conventional biosensors. Dielectrophoresis, which involves the migration of polarized dielectric particles in a non-uniform alternating electric field, has previously been successfully applied to achieve a 1000-fold improved detection efficiency in nanopore sensing and may significantly increase the sensitivity in microring resonator biosensing. In the current work, we designed microring resonators with integrated electrodes next to the sensor surface that may be used to explore the effect of dielectrophoresis. The chip design, including two different electrode configurations, electric field gradient simulations, and the fabrication process flow of a dielectrohoresis-enhanced microring resonator-based sensor, is presented in this paper. Finite element method (FEM) simulations calculated for both electrode configurations revealed ∇E2 values above 1017 V2m−3 around the sensing areas. This is comparable to electric field gradients previously reported for successful interactions with larger molecules, such as proteins and antibodies.

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Section: Introductionmentioning

confidence: 99%

An Approach to Ring Resonator Biosensing Assisted by Dielectrophoresis: Design, Simulation and Fabrication

et al. 2020

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“…RAIRS spectrum of 1 immobilized on silicon (solid line) and pentadecyne immobilized onto silicon (dashed line). Immobilized pentadecyne which in analogue to compound 1 have 12 CH 2 groups and 1 CH 3 groups was previously calculated to form ordered monolayer tilted approximately 30° to the surface normal . The very similar IR spectrum of grafted 1 strongly indicate an ordered monolayer with a similar orientation to the surface.…”

Section: Resultsmentioning

confidence: 93%

Click Coupling Reactions on Flat and Nanostructured Hydrogen‐Passivated Silicon Surfaces

Henriksson

Hoffmann

2018

Physica Status Solidi (a)

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Dialkynes are grafted onto hydrogen‐passivated silicon wafers, porous silicon, and silicon nanowires via thermally induced hydrosilylation followed by surface functionalization via azide alkyne cycloaddition. The surfaces are characterized with Fourier transform infrared spectroscopy (FTIR) and electrochemical measurements that indicate a correlation between the quality of the organic layer and the morphology of the substrate. After the initial hydrosilylation reaction, the amount of accessible surface bonded alkynes is observed to be substantially lower on porous, irregular surfaces compared to flat wafers and well‐defined vertically aligned silicon nanowire arrays, thus precluding an effective subsequent azide‐alkyne cycloaddition on porous silicon.

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“…A palladium‐catalyzed immobilization strategy for the grafting of aromatic compounds onto a hydrogen‐terminated Si surfaces without the formation of multilayers was reported by Yamanoi et al. [ 29 ] The strategy has been successful on Si(111), Si(100) as well as on porous substrates [ 31 ] and is an additional tool that may expand the number of aromatic molecules that can be attached to the surface, thus improving for example the electron transfer in electrochemical sensor devices.…”

Section: Grafting Organic Molecules To H Passivated Siliconmentioning

confidence: 99%

“…Atomic force microscopy (RMS) [29,30] <1 Å (atomic flat) 0.1-0.3 nm FTIR [9] 1242, 1052 v(SiO 2 ) v(2085 cm −1 ) monohydride v(2085 cm −1 ) mono-, v(2115 cm −1 ) di-and v(2142 cm −1 ) tri-hydride stretching XPS [31] Si 2p, 104 eV (oxide peak) Absence of oxide peak Absence of oxide peak Water contact angle [32] < 10°≈84°≈84°A…”

Section: General About Bioconjugationmentioning

confidence: 99%

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Functionalization of Oxide‐Free Silicon Surfaces for Biosensing Applications

Henriksson

Neubauer

Birkholz

2021

Adv Materials Inter

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As an alternative to standard silicon biofunctionalization protocol based on alkoxysilanes that bind to SiO2 on oxidized silicon substrates, several protocols to form bifunctional interlayers that directly bind to the silicon surface via a strong SiC bond have been developed during the last decades. These interlayers are more stable, and the lack of an insulating layer between the substrate and the interlayer reduces electric noise in biosensor devices. SiC monolayers are not yet regularly applied as the protocols are more complex and generally require an inert gas atmosphere. However, a variety of applications and new methods to form bifunctional SiC interlayers are recently developed. Here, the role these innovative protocols and interlayers play in biofunctionalization of silicon surfaces is reviewed and their applications in electrochemical, microelectromechanical, and optical biosensing are reported. From the analysis of the current situation, it can be concluded that the advantageous properties offered with this approach in many cases more than outweigh the additional processes to form SiC bonded interlayers and the approach is predicted to expand the applications of future silicon‐based biosensors.

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Attachment chemistry of aromatic compounds on a Silicon(100) surface

Cited by 7 publications

References 25 publications

An Approach to Ring Resonator Biosensing Assisted by Dielectrophoresis: Design, Simulation and Fabrication

An Approach to Ring Resonator Biosensing Assisted by Dielectrophoresis: Design, Simulation and Fabrication

Click Coupling Reactions on Flat and Nanostructured Hydrogen‐Passivated Silicon Surfaces

Functionalization of Oxide‐Free Silicon Surfaces for Biosensing Applications

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