Given the repercussions of residential mobility, increased understanding of correlates of mobility is important for efforts to support family well-being. Using survey data on low-income families from the Three City Study (N = 2393), multilevel mixed longitudinal analyses examined factors associated with family residential mobility across the domains of family instability, housing and neighborhood contexts, and family characteristics. Results revealed contributions of family instability and housing and neighborhood contexts to residential mobility, with a higher rate of residential moves associated with experiences of intimate partner violence, relationship transitions, and job transitions, as well as with living in private-market rentals, substandard housing, and disordered neighborhoods. However, owning a home and living in disadvantaged neighborhoods predicted a lower rate of residential moves.