Attempting to define and refine vasopressin use in septic shock: the VANISH trial

Roy, Aviral; Dellinger, R Phillip

doi:10.21037/atm.2016.12.11

Cited by 1 publication

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vasopressin was under scrutiny for its potential effect on reducing the risk of acute kidney injury progression in septic patients, which was sparked by post hoc analysis of the VAST trial [ 83 ]. Results of the VANISH trial did not confirm such a hypothesis; however, because the study design was probably underpowered, further discussion on this subject is warranted [ 84 , 85 ]. It is important because COVID-19 patients have a risk of AKI reaching 22.2–36.6% [ 10 , 86 ].…”

Section: Pharmacotherapy – Vasopressorsmentioning

confidence: 99%

COVID-19 and haemodynamic failure: a point of view on mechanisms and treatment

Jasiński¹,

Stefaniak²

2020

ait

View full text Add to dashboard Cite

The SARS-CoV-2-related disease has an undoubted impact on the healthcare system. In the treatment of severe COVID-19 cases, the main focus is on respiratory failure. However, available data suggest an important contribution of haemodynamic impairment in the course of this disease. SARS-CoV-2 may affect the circulatory system in various ways that are universal for septic conditions. Nonetheless, unique features of this pathogen, e.g. direct insult leading to myocarditis and renin-angiotensin-aldosterone axis dysregulation, must be taken into account. Although current recommendations on COVID-19 resemble previous septic shock guidelines, special attention to haemodynamic monitoring and treatment is necessary. Regarding treatment, one must take into account the potential profound hypovolaemia of severe COVID-19 patients. Pharmacological cardiovascular support should follow existing guidelines and practice. Interesting concepts of decatecholaminisation and the effect of vasopressors on pulmonary circulation are also presented in this review on COVID-19-related haemodynamic failure.

show abstract