Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field

Sharma, Vijay; Pathak, Kamla

doi:10.18869/acadpub.pbr.2.4.1

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…This is further adsorbed on the porous carrier material. A liquid layer starts forming on the surface of the particles, when once the carrier material is saturated with liquid, a moist or sticky blend is formed [10]. Dry and free flowing and compressible powder is obtained upon addition of dry coating material that physically exists in a very fine powder, instantly adsorbs fine layer of drug solution over the carrier material.…”

Section: Basis Of Selection Of Excipients In Ls Technologymentioning

confidence: 99%

Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs

Kasturi¹

2023

Drug Formulation Design

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Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of poorly aqueous soluble drugs. Initially, liquid medication (liquid drug or drug solution or suspension in hydrophilic liquid vehicle) is transformed to free-flowing, non-sticky, compressible powder by the addition of suitable carrier material and coating materials for the development of liquisolid compacts. The postulated mechanism for enhanced solubility was improved wettability of drug and enhanced surface area of molecularly dispersed drug in the liquid environment. Pre- and post-the compression tests were performed for the developed liquisolid compacts to obtain optimized formulation. For the optimized compacts, FTIR and DSC studies were performed for determining drug-excipient compatibility; SEM and PXRD studies were performed to study the solid-state characterization. Furthermore, accelerated stability studies were performed for optimized liquisolid compacts for 6 months according to ICH guidelines and the results were compared with freshly prepared formulations. In conclusion, liquisolid compact formulation was proved to be safe, economic and alternative approach to formulate solid oral dosage forms of poorly aqueous soluble drugs.

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Section: Basis Of Selection Of Excipients In Ls Technologymentioning

confidence: 99%

Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs

Kasturi¹

2023

Drug Formulation Design

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“…Liquisolid characterization can be predicted in several stages; first, knowing whether the mixture of liquisolid can have an amorphous form that can increase drug release. Second, determine the interaction of the active ingredients used with the addition of excipients (16). Liquisolid characterization includes physical characterization and physicochemical characterization.…”

Section: Characterization Of Liquisolid Characterization Of Physics Pmentioning

confidence: 99%

Enhancement of Solubility BCS Class II and IV Pharmaceuticals by Liqusolid Technique: A review

2020

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Many techniques can be used to improve drug solubility, which is the development of the liquisolid technique. This technique has a mechanism for increasing the surface area of the drug as well as wetting from the addition of non-volatile solvents resulting in a lower surface tension and contact angle, so the solubility and drug release very increases. Liquisolid tablets show a lower contact angle compared to the conventional tablets. The liquisolid technique approach is also promising because the process is simple in making low production costs and allows the manufacturing industry, including non-volatile solvents, fillers, dryers, and disintegrants. Liquisolid characterized by specific instruments such as powder x-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and scanning electron microscope (SEM). Several liquisolid techniques are described in this review. The liquisolid technique is proven and able to change the physicochemical properties of active pharmaceutical ingredients, especially the solubility, drug release, and stability of the formula so that this technique can be a solution for class II and IV BCS pharmaceutical active drug classes.Keywords: Active Pharmaceutical Ingredients, Contact Angle, Solubility, Drug Release, Stability, Liquisolid Technique

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An Overview on Liquisolid Technique: Its Development and Applications

Rashad

Louis

2022

Ther. Deliv.

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With its simplicity and cost–effectiveness, the liquisolid technique offers solutions for numerous formulation problems. Among these are dissolution enhancement and sustaining drug release, and the liquisolid technique dealt with both approaches. This review focuses on the latest advances in the technique. It discusses modified additives for use as carrier materials, which secure the required large surface area for enclosing liquids. The review also covers the modern liquipellet technique derived from the extrusion/palletization technique. Also, the liquiground term is introduced, combining the advantages of co-grinding with the liquisolid concept. Furthermore, several grades of Eudragits, and hydrophilic retarding polymers are mentioned to explain modes of sustaining drug release. This review sums up the liquisolid technique development and its applications recently achieved.

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Attempts and outcomes of liquisolid technology: An updated chronological compilation of innovative ideas and adjuvants in the field

Cited by 3 publications

References 30 publications

Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs

Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous Soluble Drugs

Enhancement of Solubility BCS Class II and IV Pharmaceuticals by Liqusolid Technique: A review

An Overview on Liquisolid Technique: Its Development and Applications

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