Attending Rounds

Rastegar, Asghar

doi:10.2215/cjn.04150511

Cited by 11 publications

(10 citation statements)

References 20 publications

(19 reference statements)

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“…Some authors suggest that steroid therapy should be considered in these patients as the presence of severe dRTA causing hypokalemic paralysis reflects the severity of the underlying autoimmune tubulointerstitial nephritis (3,(5)(6)(7)(8). As an example, Soy et al reported a primary Sjögren syndrome patient with dRTA who presented with symptoms of HPP.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Attacks of Hypokalemic Quadriparesis: An Unusual Presentation of Primary Sjögren Syndrome

et al. 2016

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We herein report the case of a 64-year old woman with recurrent attacks of hypokalemic quadriparesis which resulted from distal renal tubular acidosis (dRTA) secondary to Sjögren syndrome. The patient presented with sudden onset quadriparesis. A physical examination showed symmetric weakness of all four limbs. Severe hypokalemia (1.8 mEq/L), accompanied by normal anion gap metabolic acidosis, a positive urine anion gap and an inappropriately high urine pH pointed toward the diagnosis of dRTA. Further investigations disclosed primary Sjögren syndrome, which had not previously been recognized. On the basis of the current report and a review of the literature we suggest investigating the possibility of Sjögren syndrome in all patients with clinically unexplained dRTA.

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Section: Discussionmentioning

confidence: 99%

Recurrent Attacks of Hypokalemic Quadriparesis: An Unusual Presentation of Primary Sjögren Syndrome

et al. 2016

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“…The clinical spectrum of renal tubular acidosis may be silent to life-threatening 4. In Sjogren's syndrome, severe symptomatic hypokalemia with periodic paralysis and respiratory arrest has been reported in only a few cases 8 9. Potassium deficiency can induce muscle ischaemia and, in case of severe depletion, muscle necrosis and rhabdomyolysis.…”

Section: Discussionmentioning

confidence: 99%

Hypokalemic rhabdomyolysis: an unusual presentation of Sjogren's syndrome

et al. 2013

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SUMMARYHypokalaemic rhabdomyolysis represents a medical emergency requiring rapid diagnosis and appropriate aetiological treatment. Renal tubular acidosis is a common cause of hypokalemia which can be idiopathic or secondary to systemic disorders such as Sjogren's syndrome. It can remain asymptomatic or manifest with metabolic abnormalities including hypokalemia paralysis, hypocalcaemia and hyperchloremic metabolic acidosis. Rhabdomyolysis presenting with severe hypokalemia as the first manifestation of Sjogren's syndrome is rare. We report a case of a 59-year-old woman who presented to our department with severe weakness of all limbs. Laboratory examination demonstrated hypokalemic rhabdomyolysis caused by distal renal tubular acidosis. Investigations revealed Sjogren's syndrome as the underlying cause of the metabolic disorders. BACKGROUND

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“…In support of the possible pathogenic role of anti-CAII antibodies, mice injected with human CAII develop antibodies to this protein and develop a syndrome similar to Sjögren syndrome with lymphocytic and plasma cell infiltration in the salivary glands and kidneys along with a urinary acidification defect (42). However, it is not clear that immunosuppressive therapy improves the RTA associated with Sjögren syndrome (43).…”

Section: Question 2amentioning

confidence: 99%

American Society of Nephrology Quiz and Questionnaire 2014

Rosner

Perazella

Choi

2015

Clinical Journal of the American Society of Nephrology

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The Nephrology Quiz and Questionnaire remains an extremely popular session for attendees of the Annual Kidney Week Meeting of the American Society of Nephrology. Once again, in 2014 the conference hall was overflowing with audience members and eager quiz participants. Topics covered by the expert discussants included electrolyte and acid-base disorders, glomerular disease, ESRD/dialysis, and transplantation. Complex cases from each of these categories along with single-best-answer questions were prepared and submitted by the panel of experts. Before the meeting, program directors of United States nephrology training programs and nephrology fellows answered the questions using an Internet-based questionnaire. During the live session, members of the audience tested their knowledge and judgment on a series of case-oriented questions prepared and discussed by the experts. They compared their answers in real time using audience response devices with the answers of the nephrology fellows and training program directors. The correct and incorrect answers were then discussed after the audience responses and the results of the questionnaire were displayed. As always, the audience, lecturers, and moderators enjoyed this educational session. This article recapitulates the acid-base and electrolyte disorders portion of the session and reproduces its educational value for the readers of the Clinical Journal of the American Society of Nephrology. Enjoy the clinical cases and expert discussions.

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Attending Rounds

Cited by 11 publications

References 20 publications

Recurrent Attacks of Hypokalemic Quadriparesis: An Unusual Presentation of Primary Sjögren Syndrome

Recurrent Attacks of Hypokalemic Quadriparesis: An Unusual Presentation of Primary Sjögren Syndrome

Hypokalemic rhabdomyolysis: an unusual presentation of Sjogren's syndrome

American Society of Nephrology Quiz and Questionnaire 2014

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