Attention-Deficit/Hyperactivity Disorder and Comorbidities in 18 Paisa Colombian Multigenerational Families

Palacio, Juan David; Castellanos, F. Xavier; Pineda, David; Lopera, Francisco; Arcos‐Burgos, Mauricio; Quiroz, Yakeel T.; Henao, G. C.; Puerta, Isabel C.; Ramirez, Dora; Rapoport, Judith L.; Bailey-Wilson, Joan E.; Berg, Kate; Muenke, Maximilian

doi:10.1097/01.chi.0000142279.79805.dc

Cited by 54 publications

(80 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Untersuchungen über den Zusammenhang zwischen der ADHS und dem Tabakkonsum konnten nachweisen, dass der Raucheranteil bei ADHS-Patienten höher ist als der Raucheranteil in der Allgemeinbevölkerung [7,16]. Zudem wiesen täglich rauchende ADHS-Patienten höhere Tabakkonsumwerte und eine stärkere Nikotinabhängigkeit auf als Personen ohne ADHS und hatten in einem jüngeren Alter begonnen, regelmässig zu rauchen [12][13][14][15] …”

Section: Resultsunclassified

Tabakkonsum bei Erwachsenen mit ADHS

2010

View full text Add to dashboard Cite

Zusammenfassung HintergrundUntersuchungen aus den USA wiesen Zusammenhänge zwischen der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) und dem Rauchen nach. Bis anhin wurden in der Schweiz keine vergleichbaren Studien durchgeführt. Ziel der vorliegenden Arbeit war es, neue Erkenntnisse über die Beziehung der ADHS und dem Tabakkonsum bei erwachsenen ADHS-Patienten aus der Schweiz zu gewinnen. Material und MethodenEine schriftliche Befragung zum Tabakkonsum and smoking behaviour; however, no specific work on this topic has been done in Switzerland. The aim of the study was to gain knowledge about the association between attention-deficit/hyperactivity disorder (ADHD) and tobacco consumption in a Swiss sample of adult ADHD patients. MethodsStudy subjects were recruited from patients with a DSM-IV diagnosis of ADHD consecutively presenting to the ADHD consultation service at the Centre of Addiction Disorders, an out-patient facility of the Zurich University Hospital, between September 2000 and January 2006. Complete data could be obtained from 100 out of 134 patients presenting to the service. ResultsThe number of current smokers in the ADHD sample was significantly elevated compared to the Swiss general population (55% vs. 31%). Additionally, daily smokers in the ADHD sample smoked significantly more cigarettes per day, reported higher levels of nicotine dependence and started to smoke regularly at a significantly younger age. The motivation to quit smoking was high. 5 ConclusionsThe results of this Swiss study are consistent with previous research in the United States. The fact that many adults with ADHD are motivated to quit smoking and that they actually make use of support in quitting is crucial for secondary tobacco prevention. ADHS-Symptomatik und TabakkonsumAufgrund der geringen Anzahl von ADHS-Patienten mit einem hyperaktiv-impulsiven Subtypus (n = 7) waren die Voraussetzungen für den χ

show abstract

Section: Resultsunclassified

Tabakkonsum bei Erwachsenen mit ADHS

2010

View full text Add to dashboard Cite

show abstract

“…4 We used 18 extended families with 433 individuals, and 137 nuclear Table 1). A total of 1410 families with 6360 individuals were evaluated.…”

Section: Subjectsmentioning

confidence: 99%

“…13 We identified large and multigenerational families from a genetic isolate, the Paisa population in Antioquia, Colombia. 4,14 The prevalence of ADHD is high and often comorbid with disruptive behaviors in the Paisa. 4 This makes the Paisa population wellsuited for a linkage study to discover new genes that contribute to the etiology of ADHD.…”

Section: Introductionmentioning

confidence: 99%

“…4,14 The prevalence of ADHD is high and often comorbid with disruptive behaviors in the Paisa. 4 This makes the Paisa population wellsuited for a linkage study to discover new genes that contribute to the etiology of ADHD. The initial study in our program of research evaluated ADHD symptoms in informative families ascertained in the Paisa and concluded that they would provide exceptionally good power to detect linkage even in the presence of heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

“…4 Genetic factors are strongly implicated in the etiology of ADHD. 5 More than a decade ago, candidate gene association studies identified two genes with small effects, 6,7 and these associations have been replicated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

et al. 2010

View full text Add to dashboard Cite

Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors. We used the integration of statistical and functional approaches to discover a novel gene that contributes to ADHD. For our statistical approach, we started with a linkage study based on large multigenerational families in a population isolate, followed by fine mapping of targeted regions using a familybased design. Family-and population-based association studies in five samples from disparate regions of the world were used for replication. Brain imaging studies were performed to evaluate gene function. The linkage study discovered a genome region harbored in the Latrophilin 3 gene (LPHN3). In the world-wide samples (total n = 6360, with 2627 ADHD cases and 2531 controls) statistical association of LPHN3 and ADHD was confirmed. Functional studies revealed that LPHN3 variants are expressed in key brain regions related to attention and activity, affect metabolism in neural circuits implicated in ADHD, and are associated with response to stimulant medication. Linkage and replicated association of ADHD with a novel non-candidate gene (LPHN3) provide new insights into the genetics, neurobiology, and treatment of ADHD.

show abstract