Attention enhancing effects of methylphenidate are age-dependent

Bhattacharya, Shevon E.; Shumsky, Jed S.; Waterhouse, Barry D.

doi:10.1016/j.exger.2014.11.006

Cited by 15 publications

(6 citation statements)

References 40 publications

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“…In contrast to the therapeutic effects of low-dose MP in the ELS ADHD-type animals, MP treatment in control animals in general induced hyperactive behavior and reduced attentiveness. Pharmacological studies, which tested the behavioral effects of MP treatment in behaviorally normal rodents, also observed typical stimulant effects such as increased locomotor activity (Thanos et al 2015 ; Haleem et al 2015 ; Berridge et al 2006 ), but in contrast to our study improved attention (Bhattacharya et al 2015 ).…”

Section: Discussioncontrasting

confidence: 41%

Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions: functional imaging of methylphenidate treatment in a novel rodent model

et al. 2016

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In a novel animal model Octodon degus we tested the hypothesis that, in addition to genetic predisposition, early life stress (ELS) contributes to the etiology of attention-deficit hyperactivity disorder-like behavioral symptoms and the associated brain functional deficits. Since previous neurochemical observations revealed that early life stress impairs dopaminergic functions, we predicted that these symptoms can be normalized by treatment with methylphenidate. In line with our hypothesis, the behavioral analysis revealed that repeated ELS induced locomotor hyperactivity and reduced attention towards an emotionally relevant acoustic stimulus. Functional imaging using (14C)-2-fluoro-deoxyglucose-autoradiography revealed that the behavioral symptoms are paralleled by metabolic hypoactivity of prefrontal, mesolimbic and subcortical brain areas. Finally, the pharmacological intervention provided further evidence that the behavioral and metabolic dysfunctions are due to impaired dopaminergic neurotransmission. Elevating dopamine in ELS animals by methylphenidate normalized locomotor hyperactivity and attention-deficit and ameliorated brain metabolic hypoactivity in a dose-dependent manner.

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Section: Discussioncontrasting

confidence: 41%

Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions: functional imaging of methylphenidate treatment in a novel rodent model

et al. 2016

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“…Patients included in this multinational study were mainly adults (94.7%), of which, 47.3% were aged ≥65 years. Hence, we believe this age group is likely to have received methylphenidate for mixed purposes 36 such as ADHD, cognitive impairment, 37 revitalizations, 38,39 or palliative care 40 . Our age‐stratified analysis of patients aged ≥20 years also showed that methylphenidate did not trigger myocardial infarction as its incidence rate was already increased in the period prior to initiating methylphenidate.…”

Section: Discussionmentioning

confidence: 61%

Association between methylphenidate and risk of myocardial infarction: A multinational self‐controlled case series study

Jeong

Lee

Lai

et al. 2021

Pharmacoepidemiology and Drug

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Purpose To investigate the association between use of methylphenidate and risk of myocardial infarction among Asians. Methods We conducted a multinational self‐controlled case series study using nationwide healthcare databases of South Korea (2002–2018), Taiwan (2004–2015), and Hong Kong (2001–2016). Of patients with myocardial infarction who were also prescribed methylphenidate within the observation period, methylphenidate use was classified into four mutually exclusive periods by each person‐day: exposed (exposed to methylphenidate), pre‐exposure (prior to the first methylphenidate prescription), washout (after the end of methylphenidate treatment), and baseline (unexposed to methylphenidate). Risk of myocardial infarction among the three periods of methylphenidate use was compared to the baseline period using conditional Poisson regression analysis to estimate incidence rate ratios (IRRs) with 95% confidence intervals (CIs). Results We identified 2104, 484, and 30 patients from South Korea, Taiwan, and Hong Kong, respectively. Risk of myocardial infarction was the highest during the pre‐exposure period in all three populations: South Korea, pre‐exposure (IRR 3.17, 95% CI 3.04–3.32), exposed (1.05, 1.00–1.11), washout (1.92, 1.80–2.04); Taiwan, pre‐exposure (1.97, 1.78–2.17), exposed (0.72, 0.65–0.80), washout (0.56, 0.46–0.68); Hong Kong, pre‐exposure (18.09, 8.19–39.96), exposed (9.32, 3.44–25.28), washout (7.69, 1.72–34.41). Following stratification for age and sex, the trends remained analogous to the main findings across all three populations. Conclusions Although a positive association between initiating methylphenidate and the onset of myocardial infarction was observed, the risk was the highest in the period before its initiation. Thus, this multinational study suggests there was no causal relationship between methylphenidate and myocardial infarction among Asians.

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“…Normal age-related cognitive decline is related to pharmacological therapies (Hanlon et al, 2001); but until recently, evidence concerning the safety of these treatments was lacking (Bhattacharya et al, 2015). Physical activity (PA) might offer hope for combating the deleterious effects of dementia while simultaneously reducing the need for pharmacological interventions.…”

Section: Introductionmentioning

confidence: 99%

“…Over time, these losses may proceed to more serious cognitive disorders, such us dementia and functional mobility impairment (Bhattacharya et al, 2015). Executive functioning and attention are important in the regulation of functional mobility (MonteroOdasso et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of different types of physical activity on the cognitive functions and attention in older people: A randomized controlled study

Iuliano

Cagno

Aquino

et al. 2015

Experimental Gerontology

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Attention enhancing effects of methylphenidate are age-dependent

Cited by 15 publications

References 40 publications

Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions: functional imaging of methylphenidate treatment in a novel rodent model

Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions: functional imaging of methylphenidate treatment in a novel rodent model

Association between methylphenidate and risk of myocardial infarction: A multinational self‐controlled case series study

Effects of different types of physical activity on the cognitive functions and attention in older people: A randomized controlled study

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