The major depressive disorder (MDD) is a common mental disability, characterized by persistent low mood, reduced vitality and interest, worse sleep, and high suicidal tendency. 1,2 It affects more than 350 million people throughout the world. 3,4 It is predicted that MDD would rank the first cause of disease burden by 2030. 5 The severe impact of MDD on human beings raised the necessity for its treatment. Accordingly, various therapeutic methods have been applied, including antidepressants, psychotherapy, and physical therapy. Antidepressants were the dominant method in MDD treatment, although it was accompanied by side effects such as insomnia, weight gain, loss of appetite, drug dependence, and other physiological responses that would have dramatic influences on people's daily life. [6][7][8] Besides that, the uncertainty of which medicine works well for a particular patient took a lot of time, effort, and money for treatment, resulting in unnecessary side effects and low medication adherence. 7,9 These weaknesses