Attenuated DHEA and DHEA-S response to acute psychosocial stress in individuals with depressive disorders

Jiang, Xiaoling; Zhong, Wen; An, Haiyan; Fu, Mingyu; Chen, Yuanyuan; Zhang, Zhenggang; Xiao, Zhongju

doi:10.1016/j.jad.2017.03.013

Cited by 25 publications

(29 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 , 4 The salivary level of DHEAS was significantly lower in patients with RAU than controls. A low salivary DHEAS level is reportedly more common in individuals with depression, 29 , 30 as mentioned above, and depression is an important risk factor for the onset of RAU. 8 Additionally, DHEAS has been shown to be a negatively predictor of salivary immunity, in that a decreased DHEAS level may be associated with a decline in salivary immunity; thus, DHEAS may be correlated with an increased risk of RAU onset.…”

Section: Discussionmentioning

confidence: 86%

Salivary metabolomics profile of patients with recurrent aphthous ulcer as revealed by liquid chromatography–tandem mass spectrometry

Wang

Liu

et al. 2018

J Int Med Res

View full text Add to dashboard Cite

ObjectiveWe compared the salivary nontargeted metabolite profiles between patients with recurrent aphthous ulcer (RAU) and healthy individuals to investigate the metabolic alterations associated with RAU.MethodsSaliva samples were collected from 45 patients with RAU and 49 healthy individuals, and the salivary metabolites were quantified using liquid chromatography–tandem mass spectrometry. The metabolomic profiles were then analyzed using multivariate and univariate statistical methods, and enrichment of the metabolites in various biological pathways was assessed.ResultsIn total, 206 significant differentiating metabolites (Wilcoxon test, false discovery rate [FDR] of <0.05) were identified between patients with RAU and healthy individuals. These metabolites were implicated in tryptophan metabolism, steroid hormone biosynthesis, and other metabolic pathways. Two commonly circulating steroids, estrone sulfate and dehydroepiandrosterone sulfate, were significantly lower in the saliva of patients with RAU (Wilcoxon test, FDR < 0.05, power > 0.9). Principal component analysis and partial least-squares discriminant analysis revealed metabolic perturbations involving RAU, and receiver operating characteristic curve analysis with several metabolites showed good diagnostic ability for RAU.ConclusionsThe results of this study indicate that patients with RAU are characterized by metabolic imbalances. Psychogenic factors, endocrinopathies, and immunosuppression may contribute to the onset of RAU.

show abstract

Section: Discussionmentioning

confidence: 86%

Salivary metabolomics profile of patients with recurrent aphthous ulcer as revealed by liquid chromatography–tandem mass spectrometry

Wang

Liu

et al. 2018

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…Importantly, relatively lower basal levels of DHEA to cortisol are implicated in some psychiatric disorders (for reviews, see Maninger et al, 2009;Walker, Pfingst, Carnevali, Sgoifo, & Nalivaiko, 2017). Additionally, DHEA responses to acute stress are associated with better cognitive function following stress (Shields, Lam, Trainor, & Yonelinas, 2016) and are blunted in depressed individuals (Jiang et al, 2017).…”

Section: Stress and The Hpa Axis Responsementioning

confidence: 99%

“…Importantly, relatively lower basal levels of DHEA to cortisol are implicated in some psychiatric disorders (for reviews, see Maninger et al, ; Walker, Pfingst, Carnevali, Sgoifo, & Nalivaiko, ). Additionally, DHEA responses to acute stress are associated with better cognitive function following stress (Shields, Lam, Trainor, & Yonelinas, ) and are blunted in depressed individuals (Jiang et al, ). Because of these and other reasons, DHEA has been proposed as a mechanism underpinning biological resilience to stress (Charney, ; Feder, Nestler, & Charney, ; Maninger et al, ; Pfau & Russo, ; Walker et al, ).…”

Section: Introductionmentioning

confidence: 99%

Greater lifetime stress exposure predicts blunted cortisol but heightened DHEA responses to acute stress

et al. 2018

View full text Add to dashboard Cite

Although prior research has examined how early adversity and chronic stress exposure relate to hypothalamic-pituitary-adrenal (HPA) axis responses to acute stress, to date, no studies have examined how stressors occurring over the entire lifespan predict such responses. To address this issue, we recruited 61 healthy young adults and measured their exposure to 55 different types of acute life events and chronic difficulties occurring over the lifespan. In addition, we characterized differences in participants' HPA axis responses to acute stress by measuring their salivary cortisol and DHEA responses to the Trier Social Stress Test for Groups. Greater cumulative stress exposure was associated with a blunted cortisol response, but a heightened DHEA response, to the acute stressor. Moreover, it was participants' exposure to these stressors (i.e., lifetime count), not their perceived severity, which predicted their cortisol and DHEA responses to acute stress. Furthermore, differential effects were observed by stress exposure domain. Notably, only adulthood and marital/partner stressors significantly predicted cortisol responses to acute stress, whereas stress was more uniformly associated with DHEA responses to the acute stressor. These results thus reveal how cumulative stress exposure is associated with HPA axis responsivity to acute stress, while highlighting the fact that different stressors may have substantially different associations with these biological outcomes.

show abstract

“…[26][27][28][29] DHEA-S showed to have a long half-life and slower clearance rate thus; it serves as a reservoir for DHEA. 30 In stress, DHEA is primarily released from the adrenal in parallel with cortisol in response to HPA axis activation by ACTH. 27,29 A strong regulatory influence of DHEA was reported on the HPA upon release.…”

Section: Introductionmentioning

confidence: 99%

<p>Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression</p>

Alghadir¹,

Gabr²

2020

CIA

View full text Add to dashboard Cite

Background: Poor daily life physical activities among older people were related to depressive mood especially memory loss. In addition to that, the change in physical ability is significantly associated with the score of depression among older age. Objective: The present study aimed to evaluate the effects of a supervised aerobic training program with moderate intensity for 12 weeks on mood profiles and hormonal levels of the hypothalamus-pituitary-adrenal axis (HPA axis) of older adults. Methods: A total of 80 individuals of both gender (90 males, 110 females) of ages ranged between 65 and 95 years were recruited for this study. Based upon the profile of mood states (POMS) analysis, the participants were classified into two groups: control group (n=30) and depressive group (n=50). Leisure-time physical activity (LTPA), adrenal hormones such as ACTH, corticosterone (CORT), cortisol, DHEA/S, and cortisol:DHEA/S ratio were measured at baseline and post-intervention of moderate aerobic exercise for 12 weeks. Results: Older adults with higher depressive scores showed a remarkable change in the level of adrenal hormones compared to control. There was a significant increase in the level of ACTH, CORT, cortisol, and cortisol:DHEA/S ratio, and decrease in DHEA/S. Compared to females, males showed an improvement in depressive mood score along with an increase in LPTA, DHEA/S and decrease in ACTH, CORT, cortisol, cortisol:DHEA/S ratio following 12 weeks of supervised aerobic training, respectively. Conclusion: The findings of this study showed that 12 weeks of supervised exercise interventions are promising non-drug therapeutic strategies in improving depression among older adults. The potential performance in a psychological state occurs physiologically via optimizing the levels of the hormones of the HPA axis.

show abstract

Attenuated DHEA and DHEA-S response to acute psychosocial stress in individuals with depressive disorders

Cited by 25 publications

References 35 publications

Salivary metabolomics profile of patients with recurrent aphthous ulcer as revealed by liquid chromatography–tandem mass spectrometry

Salivary metabolomics profile of patients with recurrent aphthous ulcer as revealed by liquid chromatography–tandem mass spectrometry

Greater lifetime stress exposure predicts blunted cortisol but heightened DHEA responses to acute stress

<p>Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression</p>

Contact Info

Product

Resources

About