Attenuated Free Cortisol Response to Psychosocial Stress in Children with Atopic Dermatitis

Buske‐Kirschbaum, Angelika; Jobst, Silke; Wustmans, Andrea; Kirschbaum, Clemens; Rauh, W; Hellhammer, Dirk H.

doi:10.1097/00006842-199707000-00012

Cited by 623 publications

(463 citation statements)

References 29 publications

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“…Next, they completed a 5-min baseline resting period where they were asked to sit quietly without moving. Participants then completed three laboratory-based procedures designed to elicit a physiological response: (i) a peer-evaluation task (65) that was passive in nature (i.e., did not require active responses by the participant); (ii) an evaluated social performance task requiring instrumental cognitive responses-the TSST (66), a widely used stress induction procedure that has been used with children and adolescents (67,68); and (iii) a nonsocial task designed to elicit frustration that required active responses. Each task was followed by a 5-min recovery period during which children were asked to sit quietly, to eliminate carryover effects from one task to another.…”

Section: Methodsmentioning

confidence: 99%

Causal effects of the early caregiving environment on development of stress response systems in children

McLaughlin

Sheridan

Tibu³

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

381

330

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Disruptions in stress response system functioning are thought to be a central mechanism by which exposure to adverse early-life environments influences human development. Although early-life adversity results in hyperreactivity of the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis in rodents, evidence from human studies is inconsistent. We present results from the Bucharest Early Intervention Project examining whether randomized placement into a family caregiving environment alters development of the autonomic nervous system and HPA axis in children exposed to early-life deprivation associated with institutional rearing. Electrocardiogram, impedance cardiograph, and neuroendocrine data were collected during laboratorybased challenge tasks from children (mean age = 12.9 y) raised in deprived institutional settings in Romania randomized to a highquality foster care intervention (n = 48) or to remain in care as usual (n = 43) and a sample of typically developing Romanian children (n = 47). Children who remained in institutional care exhibited significantly blunted SNS and HPA axis responses to psychosocial stress compared with children randomized to foster care, whose stress responses approximated those of typically developing children. Intervention effects were evident for cortisol and parasympathetic nervous system reactivity only among children placed in foster care before age 24 and 18 months, respectively, providing experimental evidence of a sensitive period in humans during which the environment is particularly likely to alter stress response system development. We provide evidence for a causal link between the early caregiving environment and stress response system reactivity in humans with effects that differ markedly from those observed in rodent models.childhood adversity | early-life stress | HPA axis | autonomic nervous system | stress reactivity D isruptions in stress response system functioning are thought to be a central mechanism by which exposure to adverse early-life environments influences human development. This idea is borne out in rodent models, where the effects of early-life adversity on the development of stress response systems have been well characterized. Exposure to early-life adversityinvolving repeated and prolonged separation of a pup from its mother-results in hyperreactivity of the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis in adolescence and adulthood and elevations in anxiety, fearful behaviors, and hypervigilance (1-4). Stress exposure in mature rodents is associated with immediate, but not lasting, changes in stress response systems (5, 6), suggesting the presence of an early sensitive period when exposure to adverse environments results in long-term changes in physiological stress response system functioning.

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Section: Methodsmentioning

confidence: 99%

Causal effects of the early caregiving environment on development of stress response systems in children

McLaughlin

Sheridan

Tibu³

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

381

330

View full text Add to dashboard Cite

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“…After 30 minutes of sedentary activity (questionnaire and computer task completion), the baseline saliva sample was collected. Saliva samples were then collected 20 minutes after the start of the TSST (excluding speech preparation time, so from the beginning of the speech delivery; see also Buske-Kirschbaum et al, 1997, Dickerson & Kemeny, 2004T2), 40 minutes after the start of the TSST (T3), and 60 minutes after the start of the TSST (T4). Participants drooled through a sanitary straw into a 2-ml IBL vial.…”

Section: Methodsmentioning

confidence: 99%

“…version of the TSST-C (Buske- Kirschbaum et al, 1997), a laboratory paradigm consisting of a storytelling and math task designed to elicit a stress response to a psychosocial stressor.…”

Section: Trier Social Stress Test For Children (Tsst-c) Participantsmentioning

confidence: 99%

Does socioeconomic status mediate racial differences in the cortisol response in middle childhood?

Tackett¹,

Herzhoff²,

Smack³

et al. 2017

Health Psychology

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Objective: Race/ethnicity and socioeconomic status are both associated with stress physiology as indexed by cortisol. The present study tested the extent to which racial/ethnic disparities in cortisol reactivity are explained by socioeconomic status. Method: The sample consisted of 296 racially and socioeconomically diverse children ages 8–11 (47% boys). Mothers reported on children’s stressors and socioeconomic status; salivary cortisol levels were assessed before and after the Trier Social Stress Test. Results: Results demonstrated that racial group differences in cortisol reactivity were partially accounted for by differences in socioeconomic status, but racial group differences in cortisol recovery were not. Conclusions: These findings suggest that cumulative effects of stress and disadvantage may result in differences in stress response physiology as early as middle childhood, and that race-specific mechanisms account for additional variance in cortisol reactivity and recovery.

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“…36 Human counterparts with HPA hyporesponsiveness include adults with fibromyalgia 37,38 and chronic fatigue syndrome 39,40 and children with atopic dermatitis. 41 In post-traumatic stress disorder, basal HPA activity is also low, 42,43 although reactivity to stress may not be blunted.…”

Section: Allostasis and Allostatic Loadmentioning

confidence: 99%

Protective and Damaging Effects of Stress Mediators

1998

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VER 60 years ago, Selye 1 recognized the paradox that the physiologic systems activated by stress can not only protect and restore but also damage the body. What links these seemingly contradictory roles? How does stress influence the pathogenesis of disease, and what accounts for the variation in vulnerability to stress-related diseases among people with similar life experiences? How can stress-induced damage be quantified? These and many other questions still challenge investigators.This article reviews the long-term effect of the physiologic response to stress, which I refer to as allostatic load. 2 Allostasis -the ability to achieve stability through change 3 -is critical to survival. Through allostasis, the autonomic nervous system, the hypothalamic-pituitary-adrenal (HPA) axis, and the cardiovascular, metabolic, and immune systems protect the body by responding to internal and external stress. The price of this accommodation to stress can be allostatic load, 2 which is the wear and tear that results from chronic overactivity or underactivity of allostatic systems.

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Attenuated Free Cortisol Response to Psychosocial Stress in Children with Atopic Dermatitis

Abstract: These findings suggest that the adrenocortical response to stress is attenuated in atopic children. A hyporesponsive hypothalamus-pituitary-adrenal (HPA) axis might explain in part the stress-induced eruptions of AD symptoms.

Cited by 623 publications

References 29 publications

Causal effects of the early caregiving environment on development of stress response systems in children

Causal effects of the early caregiving environment on development of stress response systems in children

Does socioeconomic status mediate racial differences in the cortisol response in middle childhood?

Protective and Damaging Effects of Stress Mediators

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