Attenuated T-Lymphocyte Response to HIV Therapy in Individuals Receiving HMG-CoA Reductase Inhibitors

Narayan, Shanil; Hawley, Nanci; Giguère, Pierre; Badley, Andrew D.

doi:10.1310/b05e-tfvn-uj8l-mfhj

Cited by 11 publications

(2 citation statements)

References 21 publications

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“…This possible negative effect was also expressed as a concern in a letter to the editor to JAIDS by Corrales-Medina et al in 2005 in response to a study showing that statin therapy decreases the T-helper-1 (Th1)/T-helper-2 (Th2) lymphocyte ratio [68, 69], the reverse of what is observed in the course of HIV infection. Indeed, the authors point out that cross-modulation and cross-regulation between Th1 and Th2 cytokines appear to be necessary in the maintenance of adequate anti-HIV CD8+ T cell responses in HIV-infected chronic non-progressors [70]. …”

Section: Implications Of Immunological Effects Of Statins In the Hiv-mentioning

confidence: 99%

“…In addition, in small retrospective cohort studies, the data suggested that the use of statins was associated with lower CD4+ T cell responses in patients on HAART [70, 71]. In contrast, however, randomized controlled trials have not observed any changes in CD4 counts with statin therapy [54•, 72].…”

Section: Implications Of Immunological Effects Of Statins In the Hiv-mentioning

confidence: 99%

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The Role of Statins in the Setting of HIV Infection

Eckard

McComsey

2015

Curr HIV/AIDS Rep

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HIV-infected individuals are at an increased risk of cardiovascular disease (CVD) and other HIV-related co-morbidities. This is due in part to dyslipidemia associated with antiretroviral therapy and increased inflammation and immune activation from chronic HIV infection. Statins not only have potent lipid-lowering properties but are also anti-inflammatory and immunomodulators. Studies suggest that statin therapy in the HIV-infected population may decrease the risk of CVD and other non-AIDS-defining co-morbidities. This review summarizes the recent literature on statin use in the HIV setting.

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Section: Implications Of Immunological Effects Of Statins In the Hiv-mentioning

confidence: 99%

Section: Implications Of Immunological Effects Of Statins In the Hiv-mentioning

confidence: 99%

The Role of Statins in the Setting of HIV Infection

Eckard

McComsey

2015

Curr HIV/AIDS Rep

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Statins for the Prevention and Treatment of Infections

Tleyjeh¹

2009

Arch Intern Med

231

162

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Statins can modulate effectiveness of antitumor therapeutic modalities

Jakóbisiak

Gołąb

2009

Medicinal Research Reviews

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Despite significant, frequently very strong, antiproliferative and tumoricidal effects of statins demonstrated in vitro, their antitumor effects in animal models are modest, and their efficacy in clinical trials has not been proven. As such, statins seem unlikely to be ever regarded as antitumor agents. However, statins are regularly taken by many elderly cancer patients for the prevention of cardiovascular events. Owing to their pleiotropic effects in normal and tumor cells, statins interact in various ways with many antitumor treatment modalities, either potentiating or diminishing their effectiveness. Elucidation of these interactions might affect the choice of treatment to be planned in cancer patients as some combinations might be contraindicated, whereas others might elicit potentiated antitumor effects but at a cost of increased general toxicity. Some other combinations might induce either comparable or even stronger antitumor effects, but with a beneficial concomitant reduction of specific side effects. Most of the studies reviewed in this article have been carried in vitro or in experimental tumor models, but clinical relevance of the findings is also discussed.

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Attenuated T-Lymphocyte Response to HIV Therapy in Individuals Receiving HMG-CoA Reductase Inhibitors

Abstract: These data suggest that T-cell responses are influenced by the choice of anti-lipid agent and suggest that a prospective comparison is needed to determine the clinical relevance of these findings.

Cited by 11 publications

References 21 publications

The Role of Statins in the Setting of HIV Infection

The Role of Statins in the Setting of HIV Infection

Statins for the Prevention and Treatment of Infections

Statins can modulate effectiveness of antitumor therapeutic modalities

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