Attenuation by a <i>Vigna nakashimae</i> extract of nonalcoholic fatty liver disease in high-fat diet-fed mice

Jeon, Byeong Tak; Heo, Rok Won; Shin, Hyun Joo; Yi, Chin-ok; Lee, Yu Hee; Joung, Han-nah; Jung, Jung Hwa; Jung, Jaehoon; Kim, Sang-Yong; Hahm, Jong Ryeal; Lee, Byong Won; Ko, Jong Min; Baek, In Youl; Kang, Sang Soo; Roh, Gu Seob

doi:10.1080/09168451.2014.882753

Cited by 9 publications

(9 citation statements)

References 50 publications

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“…To understand the effects of blueberry and bifidobacteria on NAFLD, hepatic injury induced by high-fat diet is a well-established animal model for studying NAFLD [ 64 , 65 ]. To explore the detail molecular mechanisms of effects of blueberry and bifidobacteria on NAFLD model, sirtuins may be the best candidates for the purpose.…”

Section: Discussionmentioning

confidence: 99%

Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

Ren¹,

Huang²,

Cheng³

2014

Oxidative Medicine and Cellular Longevity

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NAFLD model rats were established and divided into NAFLD model (MG group), SIRT1 RNAi (SI group), blueberry juice (BJ group), blueberry juice + bifidobacteria (BJB group), blueberry juice + SIRT1 RNAi (BJSI group), and blueberry juice + bifidobacteria + SIRT1 RNAi groups (BJBSI group). A group with normal rats was a control group (CG). BJB group ameliorated NAFLD, which was better than BJ group (P < 0.05). The lipid accumulation was lower in CG, BJ, and BJB groups than that in MG, SI, BJSI, and BJBSI groups (P < 0.05). The levels of SIRT1 and PPAR-α were higher in CG, BJ, and BJB groups than those in MG, SI, BJSI, and BJBSI groups (P < 0.05). The levels of SREBP-1c were lower in CG, BJ, and BJB groups than those in MG, SI, BJSI, and BJBSI groups (P < 0.05). The biochemical indexes SOD, GSH, and HDL-c were improved from CG to BJB group (P < 0.05). Inversely, the levels of AST and ALT, TG, TC, LDL-c, and MDA were decreased from CG to BJB group (P < 0.05). These changes enhance antioxidative capability and biochemical index of rats. Blueberry juice and bifidobacteria improve NAFLD by activating SIRTI-mediating signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

Ren¹,

Huang²,

Cheng³

2014

Oxidative Medicine and Cellular Longevity

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“…For the glucose tolerance test (GTT), the mice were fasted overnight (16 h) before the test, and the insulin tolerance test (ITT) was performed on the mice at 2 p.m., as previously described. 16 …”

Section: Methodsmentioning

confidence: 99%

“…Frozen liver sections (5 μm) were stained for 10 min with 0.5% Oil Red O (Sigma-Aldrich, St. Louis, MO, USA), washed, and then counterstained for 45 sec with Mayer's hematoxylin (Sigma-Aldrich), as previously described. 16 To determine hepatic collagen accumulation, deparaffinized liver sections were stained with Weigert's hematoxylin (Sigma-Aldrich) for 8 min, washed, restained with Sirius Red (Sigma-Aldrich) for 1 h, and washed. The sections were visualized under a BX51 light microscope (Olympus).…”

Section: Methodsmentioning

confidence: 99%

Artemisia annuaLeaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice

Kim

Heo

et al. 2016

Journal of Medicinal Food

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Artemisia annua L. (AA) is a well-known source of the antimalarial drug artemisinin. AA also has an antibacterial and antioxidant activity. However, the effect of AA extract on hepatic steatosis induced by obesity is unclear. We investigated whether AA extract prevents obesity-induced insulin resistance and hepatic steatosis in high-fat diet (HFD)-fed mice. Mice were randomly divided into groups that received a normal chow diet or HFD with or without AA for 12 weeks. We found that AA extract reduced insulin resistance and hepatic steatosis in HFD-fed mice. Western blot analysis showed that HFD-induced expression of nuclear sterol regulatory element-binding protein 1 and carbohydrate-responsive element-binding protein in the livers was decreased by AA extract. In particular, dietary administration of AA extract decreased hepatic high-mobility group box 1 and cyclooxygenase-2 expression in HFD-fed mice. AA extract also attenuated HFD-induced collagen deposition and fibrosis-related transforming growth factor-β1 and connective tissue growth factor. These data indicate that dietary AA extract has beneficial effects on hepatic steatosis and inflammation in HFD-fed mice.

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“…Mice were divided into three groups and fed for 16 weeks starting at 4 weeks of age with diets as follows: (1) normal diet (ND, 2018S, 3.1 kcal/g, Harlan Laboratories, Inc., Indianapolis, IN, USA) group; (2) high-fat diet (HFD, 45% fat, Research Diets, Inc., New Brunswick, NJ, USA) group; and (3) HFD with evogliptin (HFD + Evo) group. Based on previous studies [28,29], mice were dosed with Evo (250 mg kg −1 day −1 , Dong-A ST Co., Ltd., Seoul, Korea) daily in HFD chow. All mice were weighed weekly and sacrificed at 20 weeks of age.…”

Section: Animals and Treatmentmentioning

confidence: 99%

Protective Effects of Evogliptin on Steatohepatitis in High-Fat-Fed Mice

Kim

Jang

Roh

et al. 2020

IJMS

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There are few studies on the effects of dipeptidyl peptidase-4 inhibitors on steatohepatitis. We explored whether evogliptin (Evo), a dipeptidyl peptidase-4 inhibitor, protects against steatohepatitis in a high-fat diet (HFD)-fed mice and whether these effects involve modulation of mitophagy. Adult male C57BL/J mice were divided into the normal diet (ND), HFD (45% of energy from fat) with Evo (250 mg/kg) (HFD + Evo), and HFD groups at 4 weeks of age and were sacrificed at 20 weeks of age. The HFD group showed hepatic lipid accumulation; this was decreased in the Evo + HFD group. There was an increased 8-hydroxydeoxyguanosine (8-OHDG) expression in the HFD group compared to ND mice. However, 8-OHDG expression levels were significantly decreased in the HFD + Evo group. Expressions of the mitophagy markers PTEN-induced kinase 1 (PINK1), Parkin, and BNIP-3 (BCL2 Interacting Protein 3) were significantly increased in the HFD group. However, the expressions of these markers were lower in the HFD + Evo group than that in the HFD group. Phospho-Akt was upregulated and p53 was downregulated in the HFD + Evo group compared to the HFD group. Evogliptin may alleviate steatohepatitis in HFD-fed mice by ameliorating steatosis and oxidative stress and by modulating mitophagy in the liver.

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Attenuation by a Vigna nakashimae extract of nonalcoholic fatty liver disease in high-fat diet-fed mice

Cited by 9 publications

References 50 publications

Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

Dietary Blueberry and Bifidobacteria Attenuate Nonalcoholic Fatty Liver Disease in Rats by Affecting SIRT1-Mediated Signaling Pathway

Artemisia annuaLeaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice

Protective Effects of Evogliptin on Steatohepatitis in High-Fat-Fed Mice

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