Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant α-lipoic acid

Conlon, Brendan J.; Aran, Jean‐Marie; Erre, Jean‐Paul; Smith, David W.

doi:10.1016/s0378-5955(98)00195-6

Cited by 95 publications

(57 citation statements)

References 33 publications

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“…This agent was proved to effect better results than a number of other antioxidants, such as glutathione, histidine, and ebselen [19] . Potent free radical scavengers such as alpha-tocopherol (Vitamin E) and alpha-lipoic acid were also found to play inhibitory roles against gentamicin ototoxicity [20,21] .…”

Section: Discussionmentioning

confidence: 99%

A Prospective Experimental Study on the Protective Effect of Resveratrol against Amikacin-Induced Ototoxicity in Rats

Avcı¹,

Erkan²,

Sönmez³

et al. 2016

Int Adv Otol

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OBJECTIVE:The purpose of this study was to evaluate the protective effect of resveratrol against amikacin-induced ototoxicity in rats by otoacoustic emission and histopathology of the cochlea. MATERIALS and METHODS:This study was conducted with 31 Sprague Dawley adult female rats that were 20-21 weeks old and 190-245 g in weight. Before the drug administration, distortion product otoacoustic emission (DPOAE) tests were performed in both ears of each rat. The rats were divided into four groups. Group 1 (n=7) received ethanol 1cc 4%, Group 2 (n=8) received 600 mg/kg amikacin, Group 3 (n=8) received 10 mg/kg resveratrol and 600 mg/kg amikacin, and Group 4 (n=8) received 1cc resveratrol at 10 mg/kg. The drugs were administered once a day for 21 consecutive days. Control DPOAE tests were performed at the 7 th , 14 th , and 21 st days after the administration of drugs. At the end of the study, the rats were sacrificed and their cochleae were dissected. The cochleae were evaluated for histopathologic changes. RESULTS:There was no statistically significant difference in the DPOAE measurements before the procedure between groups. The DPOAE measurements significantly decreased after the procedure in the amikacin group. There was no statistically significant difference in DPOAE measurements after the procedure in the amikacin + resveratrol, resveratrol, and ethanol groups. The histopathologic findings supported these results. CONCLUSION:We found that if resveratrol is administered with amikacin, the severity of amikacin-induced hearing loss is decreased. These findings suggest that resveratrol, a strong antioxidant, has a protective effect in amikacin ototoxicity.

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Section: Discussionmentioning

confidence: 99%

A Prospective Experimental Study on the Protective Effect of Resveratrol against Amikacin-Induced Ototoxicity in Rats

Avcı¹,

Erkan²,

Sönmez³

et al. 2016

Int Adv Otol

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“…Different aspects of ototoxicity and preventive agents have been previously studied [1][2][3][4][5][6][7][8][9] .…”

Section: Discussionmentioning

confidence: 99%

“…There are a few agents, including deferoxamine, 2.3-dihydroxybenzoate, steroids, α-tocopherol, α-lipoic acid, salicylates, trimetazadine, thymoquinone, mannitol, β-carotene, vitamins C and E, and magnesium [5][6][7][8][9][10][11][12][13][14] , that claim to prevent gentamicin ototoxicity. NAC also was shown to protect the sensory cells of the cochlea in a culture medium from the ototoxic effect of gentamicin [15] .…”

Section: Introductionmentioning

confidence: 99%

N-acetylcysteine Prevents Gentamicin Ototoxicity in a Rat Model

Somdas¹,

Korkmaz²,

Gürgen³

et al. 2015

Int Adv Otol

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OBJECTIVE:The possible preventive effect of N-acetylcysteine (NAC) in gentamicin ototoxicity was studied with auditory brain stem responses (ABRs), otoacoustic emissions (OAEs), and histopathological investigation of the cochlea. MATERIALS and METHODS:This study is conducted on 36 rats in three groups. Gentamicin, gentamicin plus NAC, and NAC alone were intraperitoneally administered for 15 days. The rats were sacrificed to study the cochleas after testing hearing levels. RESULTS:ABR thresholds and OAEs were attenuated in the gentamicin group, in which apoptosis was detected with histopathological investigation. The group that received NAC in addition to gentamicin had better ABR thresholds and better OAEs. The histopathological evidence of apoptosis in was considerably less in this group. CONCLUSION:Gentamicin ototoxicity can be detected by ABR and OAE testing in rats, and NAC may protect the cochlear cells from apoptosis.

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“…Gentamicin is used widely in the treatment of gram-negative infections. Gentamicin is known to be potentially nephrotoxic at levels marginally above the therapeutic dose (Pedraza et al, 2000;Conlon et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Terminalia ivorensis A. Chev. Ethanolic Stem Bark Extract Protects Against Gentamicin-Induced Renal and Hepatic Damage in Rats

Ansah¹,

Moomin²,

Boadu³

2016

J App Pharm Sci

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The aim of present study was to investigate the possible protective effects of an ethanolic stem bark extract of Terminalia ivorensis on gentamicin -induced nephrotoxicity and hepatotoxicity in male Sprague-Dawley rats. Groups of animals received either gentamicin alone or in combination with 100, 300 or 1000 mg/kg of extract for a period of 14 days. On the 15 th day, the modulatory effect of Terminalia ivorensis was examined by assessing biochemical and renal markers of hepatic and renal damage. Markers of oxidative injury including reduced glutathione, superoxide dismutase, catalase and lipid peroxidation were assessed. Histology of the kidneys and the liver were also processed for analysis. The extract at a dose of 100-1000 mg/kg significantly reduced elevations in creatinine, urea and serum enzymes evokedby gentamicin. Additionally, the low levels of reduced glutathione and the antioxidant enzymes from the gentamicin treatment were significantly improved in the extract-treated animals. The results correlated well with the histopathological findings as the extract reversed the severe architectural distortions of the kidneys and liver caused by gentamicin. We conclude from the study that, the ethanolic stem bark extract of Terminalia ivorensis protects the liver and the kidneys against gentamicininduced renal and hepatic damage.

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Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant α-lipoic acid

Cited by 95 publications

References 33 publications

A Prospective Experimental Study on the Protective Effect of Resveratrol against Amikacin-Induced Ototoxicity in Rats

A Prospective Experimental Study on the Protective Effect of Resveratrol against Amikacin-Induced Ototoxicity in Rats

N-acetylcysteine Prevents Gentamicin Ototoxicity in a Rat Model

Terminalia ivorensis A. Chev. Ethanolic Stem Bark Extract Protects Against Gentamicin-Induced Renal and Hepatic Damage in Rats

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