Attenuation of cell migration and induction of cell death by aged garlic extract in rat sarcoma cells

Hu, Xu; Cao, Boqiang; Hu, Guoming; He, Jianya; Yang, Di; Wan, Yi

doi:10.3892/ijmm.9.6.641

Cited by 21 publications

(24 citation statements)

References 6 publications

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“…Recent studies have provided evidence that sarcoma cell migration was inhibited by aged garlic extract [7] and different garlic extracts [9]. However, it is still ambiguous by which agents suppress metastasis of cancer cells from garlic extracts.…”

Section: Discussionmentioning

confidence: 99%

Anti-metastatic Effect of Garlic Hexane Extract on Lung Metastasis Induced by Melanoma B16F10 Cells in Mice

Ko¹,

Rajasekar²,

Wang³

et al. 2016

Journal of Life Science

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Metastatic cancer is one of the main causes of cancer-related death since they rarely respond to available treatments. There is epidemiologic evidence that high garlic consumption decreases the incidence of cancer. Recent studies of our laboratory have revealed that a garlic-extracts is effective in suppressing metastasis. For experimental metastasis, C57BL/6 mice were injected intravenously with melanoma B16F10 cells in the tail vein, and were orally administered various concentrations (0, 50, 100 or 200 mg/kg body weight) of garlic hexane extract (GHE) for 21 days. The incidence and the area of the melanoma cell colony occupied by the poorly differentiated carcinoma were significantly lower in dose-dependent in 50, 100 and 200 mg/kg BW GHE-treated mice compared with control mice. In conclusion, the results of the present study show that GHE administration prevents lung metastasis in C57BL/6 mice.

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Section: Discussionmentioning

confidence: 99%

Anti-metastatic Effect of Garlic Hexane Extract on Lung Metastasis Induced by Melanoma B16F10 Cells in Mice

Ko¹,

Rajasekar²,

Wang³

et al. 2016

Journal of Life Science

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“…According to previous studies, 18) aged garlic extract inhibited the migration of rat sarcoma cells and suppressed the proliferation. They reported that this could be due to one or both of the active principles diallyl disulfide and allyl mercapto cysteine.…”

Section: Discussionmentioning

confidence: 99%

Growth Suppressing Effect of Garlic Compound Diallyl Disulfide on Prostate Cancer Cell Line (PC-3) in Vitro

Arumugam

Vijayababu

Palaniyandi

et al. 2005

Biological & Pharmaceutical Bulletin

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Prostate cancer is the most predominant cancer in men and prostate cancer related death increases every year. Till date, there is no effective therapy other than androgen ablation therapy. At this stage, induction of apoptosis is considered as a better strategy to control cancer. Previous studies reported that aged garlic extract suppresses cancer growth and enhances immune system against cancer. In the present study, diallyl disulfide, oil soluble organosulfur compound of garlic, was studied for its antiproliferative effect on prostate cancer cells in vitro. The suppression of cell growth was demonstrated by [ 3 H]thymidine incorporation assay. Induction of DNA damage was assessed by agarose gel electrophoresis. The results showed that diallyl disulfide inhibited the growth of prostate cancer cells in a dose dependent manner, compared to the control. At 50 m mM and 100 m mM concentrations, diallyl disulfide induced DNA damage in PC-3 cells. It is concluded that diallyl disulfide, component of aged garlic extract, inhibits proliferation of prostate cancer cells through the induction of apoptosis.

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“…Berbagai penelitian farmakologi tentang bawang putih telah banyak dilakukan, tidak hanya secara in vivo (dengan hewan percobaan) tetapi juga in vitro (dalam tabung kultur). Berbagai penelitian yang telah dikembangkan menunjukkan bahwa bawang putih mempunyai efek biologis dan farmakologis seperti antitumorigenesis, antianteroskleriosis, modulasi gula darah dan antibiosis, penghambatan pertumbuhan kanker (Wang et al, 2011), antihipertensi (Qidwai et al, 2000), aktivitas anti-oksidatif (Borek, 2001), antibakteri (dari isolasi jamur endofit pada bawang putih) (Hidayanti 2010), mencegah perkembangan metastasis tumor (Hu et al, 2002), peningkatan aktivitas fibrinolisis (Pizorno dan Murray, 2000), menghambat pertumbuhan bakteri Salmonella enteritidis, Staphylococcos aureus, dan Salmonella typhosa (Poeloengan, 2001). Selain itu, bawang putih juga dapat menurunkan gejala aflatoksin (Maryam et al, 2003).…”

Section: Pendahuluanunclassified

Parameter Fisikokimia dan Analisis Kadar Allyl Disulfide dalam Ekstrak Etanol 70% Bawang Putih (Allium sativum L.) dengan Perbandingan Daerah Tempat Tumbuh

2017

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AbstrakBawang putih (Allium sativum L.) merupakan salah satu tanaman obat yang potensial untuk dikembangkan menjadi obat tradisional. Produk obat tradisional dan tanaman obat yang berkualitas ditentukan salah satunya oleh mutu dan keamanan ekstrak. Faktor yang dapat mempengaruhi mutu salah satunya adalah daerah tempat tumbuh. Penelitian ini bertujuan untuk membandingkan beberapa nilai parameter fisikokimia serta kadar senyawa yang bertanggung jawab atas aktivitas farmakologis dalam ekstrak etanol 70% bawang putih yang didapat dari dua tempat tumbuh yaitu Bogor dan Wonosobo. Ekstrak bawang putih yang berasal dari Bogor menunjukkan hasil kadar sari larut air 62,5684%, kadar sari larut etanol 10,0779%, minyak atsiri 0,7477%, kadar allyl disulfide 1,8322%, kadar abu 2,3529%, dan kadar abu tidak larut asam 0,1115%. Ekstrak bawang putih yang berasal dari Wonosobo menunjukkan hasil kadar sari larut air 59,0007%, kadar sari larut etanol 8,9230%, minyak atsiri 0,3400%, kadar allyl disulfide 1,6542%, kadar abu 3,0196%, dan kadar abu tidak larut asam 0,4974%. Berdasarkan hasil penelitian tersebut, disimpulkan ekstrak yang mempunyai mutu paling baik adalah bawang putih yang berasal dari Bogor dengan nilai parameter spesifik yang lebih tinggi dan nilai parameter non spesifik yang lebih rendah. AbstractGarlic (Allium sativum L.) is one of the medicinal plants that has a potential to be developed to become a traditional medicine. Traditional medicinal products and medicinal plants which have good quality are determined by the quality and safety of the extract. One of many factors that can affect the quality is the growing area. This research aimed to compare the value of physicochemical parameters as well as the levels of compounds responsible for pharmacological activity in ethanol 70% extract of garlic obtained from two growing areas, Bogor and Wonosobo. The test results obtained from garlic extract of Bogor were: compound contents dissolved in water was 62.5684%, compound contents dissolved in ethanol was 10.0779%, essential oils contents was 0.7477%, levels of allyl disulfide was 1.8322%, total ash content was 2.3529%, ash content insoluble in acid was 0.1115%. While the test results obtained from garlic extract of Wonosobo: compound contents dissolved in water was 59.0007%, compound contents dissolved in ethanol was 8.9230%, essential oils contents was 0.3400%, levels of allyl disulfide was 1.6542%, total ash content was 3.0196%, ash content insoluble in acid was 0.4974%. Based on those results, the best quality extract was garlic from Bogor with higher specific parameter values and lower non-specific parameter values.

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Attenuation of cell migration and induction of cell death by aged garlic extract in rat sarcoma cells

Cited by 21 publications

References 6 publications

Anti-metastatic Effect of Garlic Hexane Extract on Lung Metastasis Induced by Melanoma B16F10 Cells in Mice

Anti-metastatic Effect of Garlic Hexane Extract on Lung Metastasis Induced by Melanoma B16F10 Cells in Mice

Growth Suppressing Effect of Garlic Compound Diallyl Disulfide on Prostate Cancer Cell Line (PC-3) in Vitro

Parameter Fisikokimia dan Analisis Kadar Allyl Disulfide dalam Ekstrak Etanol 70% Bawang Putih (Allium sativum L.) dengan Perbandingan Daerah Tempat Tumbuh

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