Parameter Fisikokimia dan Analisis Kadar Allyl Disulfide dalam Ekstrak Etanol 70% Bawang Putih (Allium sativum L.) dengan Perbandingan Daerah Tempat Tumbuh

Abstract

AbstrakBawang putih (Allium sativum L.) merupakan salah satu tanaman obat yang potensial untuk dikembangkan menjadi obat tradisional. Produk obat tradisional dan tanaman obat yang berkualitas ditentukan salah satunya oleh mutu dan keamanan ekstrak. Faktor yang dapat mempengaruhi mutu salah satunya adalah daerah tempat tumbuh. Penelitian ini bertujuan untuk membandingkan beberapa nilai parameter fisikokimia serta kadar senyawa yang bertanggung jawab atas aktivitas farmakologis dalam ekstrak etanol 70% bawang putih yang didapat dari dua tempat tumbuh yaitu Bogor dan Wonosobo. Ekstrak bawang putih yang berasal dari Bogor menunjukkan hasil kadar sari larut air 62,5684%, kadar sari larut etanol 10,0779%, minyak atsiri 0,7477%, kadar allyl disulfide 1,8322%, kadar abu 2,3529%, dan kadar abu tidak larut asam 0,1115%. Ekstrak bawang putih yang berasal dari Wonosobo menunjukkan hasil kadar sari larut air 59,0007%, kadar sari larut etanol 8,9230%, minyak atsiri 0,3400%, kadar allyl disulfide 1,6542%, kadar abu 3,0196%, dan kadar abu tidak larut asam 0,4974%. Berdasarkan hasil penelitian tersebut, disimpulkan ekstrak yang mempunyai mutu paling baik adalah bawang putih yang berasal dari Bogor dengan nilai parameter spesifik yang lebih tinggi dan nilai parameter non spesifik yang lebih rendah. AbstractGarlic (Allium sativum L.) is one of the medicinal plants that has a potential to be developed to become a traditional medicine. Traditional medicinal products and medicinal plants which have good quality are determined by the quality and safety of the extract. One of many factors that can affect the quality is the growing area. This research aimed to compare the value of physicochemical parameters as well as the levels of compounds responsible for pharmacological activity in ethanol 70% extract of garlic obtained from two growing areas, Bogor and Wonosobo. The test results obtained from garlic extract of Bogor were: compound contents dissolved in water was 62.5684%, compound contents dissolved in ethanol was 10.0779%, essential oils contents was 0.7477%, levels of allyl disulfide was 1.8322%, total ash content was 2.3529%, ash content insoluble in acid was 0.1115%. While the test results obtained from garlic extract of Wonosobo: compound contents dissolved in water was 59.0007%, compound contents dissolved in ethanol was 8.9230%, essential oils contents was 0.3400%, levels of allyl disulfide was 1.6542%, total ash content was 3.0196%, ash content insoluble in acid was 0.4974%. Based on those results, the best quality extract was garlic from Bogor with higher specific parameter values and lower non-specific parameter values.

ANTIBACTERIAL ACTIVITY AND TLC-BIOAUTOGRAPHY ANALYSIS OF THE ACTIVE FRACTIONS OF Muntingia calabura L. LEAVES AGAINST Staphylococcus aureus

“…Yield extraction results can be influenced by several factors, including biological factors and chemical factors. The biological factors include harvesting time, location of growth, plant species and plant parts used while the chemical factors include extraction methods, size, hardness, dryness of the material, type of solvent used, and types and levels of active compounds contained in plant material (Prastiwi et al, 2017).…”

PENGEMBANGAN PENYUBUR RAMBUT MENGGUNAKAN KOMBINASI EKSTRAK ETANOL HERBA PEGAGAN (Centella Asiatica (L) Urban) DAN EKSTRAK N-HEKSANA BAWANG PUTIH (Allium Sativum L)

“…Di dalam Bawang putih terdapat allicin yaitu zat bioaktif yang mudah menguap dengan kandungan sulfur dan mempunyai aktivitas antibakteri dan antijamur. Penggunaan bawang putih secara langsung dapat mengiritasi kulit dan memiliki bau yang tidak enak (7,8) . Bawang putih juga mengandung fitosterol turunan fenolik dan senyawa sulfur alil yang larut dalam lemak, serta flavonoid, alkaloid dan saponin memiliki aktivitas penyubur rambut yang diaplikasikan secara topical pada pasien Alopecia (9,10) .…”

In Vitro Test on the Effectiveness of Citrus limon and Allium sativum as Pediculicides

“…Sulfide derivatives, namely allicin, are stomach poisons that kill the target organism if allicin enters the digestive organs and is absorbed by the intestinal wall (7). Allicin is produced from alliin and alliinase enzymes formed after the processing of Allium sativum, and it is very reactive and unstable (19). This instability causes allicin to turn into a compound of allyl disulfide, which is classified as an organic synthetic pesticide (7,19) and inhibits or blocks the action of the cholinesterase and ganglion enzymes in the central nervous system terminal (7).…”

“…Some conditions that affected the differences of number of died insects from each concentration were differences in the insect sensitivity to the solution concentrations, the condition of each insect when test materials were given and when samples were taken, the environmental conditions such as the temperature at which experiment was conducted, extract storage (4,25), the extract quality (test material) which was affected by plant species, plant age, parts used, and etc. (19) The results of research conducted by Alzowahi, et al (25) showed that there were differences in the ability of Allium sativum as an antibacterial that were °s tored at 4°C and room temperature of 30 C. The essential oil will evaporate and will be followed by an oxidation process that affects the quality if it is placed uncovered during the storage process (19).…”