Attenuation of cocaine seeking in rats via enhancement of infralimbic cortical activity using stable step-function opsins

Abstract

These results suggest the utility of an SSFO-based approach for enhancing activity in a structure without driving specific patterns of neuronal firing. However, the utility of an SSFO-based approach for axon terminal stimulation remains unclear. Moreover, these results suggest that the ability of the IL to reduce cocaine seeking depends, at least in part, on rats first having undergone extinction training.

Preclinical evidence to support repurposing Everolimus for craving reduction during protracted drug withdrawal  

“…In both the appetitive and aversive domains, a dorsal-ventral distinction is reported with respect to how vmPFC regulates the expression of conditioned behavior (49)(50)(51)(52)(53)(54)(55)(56)(57). Extending prior immunoblotting results for the entire vmPFC (4), we observed increased PI3K/Akt1/mTOR activation within both subregions of rats expressing incubated cocaine-seeking (here on out referred to as cocaine-incubated rats).…”

Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration

“…The implication of the individual prefrontal cortical subregions in the incubation phenomenon is not clear, as highlighted by the contradictory results of the pharmacological manipulations performed in the different subdomains of the medial PFC during the incubation of seeking of psychostimulants (Ben-Shahar et al, 2013;Gould et al, 2015;Koya et al, 2009;Miller et al, 2017;Müller Ewald et al, 2018;Shin et al, 2018;Swinford-Jackson et al, 2016;Szumlinski et al, 2018).…”

Editorial: the psychopharmacology of extinction—from theory to therapy

“…The requirement for prefrontal cortex in appetitive memory extinction is further underscored in an in-depth review from Xue and colleagues (Zhang et al 2019). Pertinently, a report from Müller Ewald et al (2019) shows, using an optogenetic approach, that the contribution of the (infralimbic) prefrontal cortex to the reduction of cocaine-seeking depends upon the subjects’ prior extinction training.…”