Attenuation of dermal wounds via downregulating oxidative stress and inflammatory markers by protocatechuic acid rich n-butanol fraction of Trianthema portulacastrum Linn. in wistar albino rats

Ameliorative effect of biofabricated ZnO nanoparticles of Trianthema portulacastrum Linn. on dermal wounds via removal of oxidative stress and inflammation

“…In addition, wound contraction further aids reepithelialization by managing seclusion of migrant keratinocytes. 26 It may be hypothesized that topical application of ZnOTP might have directly promoted modulations of cytokines and growth factors which ultimately led to an increase in the rate of the wound repairing process as a result of rapid internalization in comparison to other groups. 36 Epithelialization of the healed wound area in the ZnOTP2% applied group was observed at 17.24 AE 0.5 days, while in the standard treated group it was found to be 18.91 AE 0.4 days and partial epithelialization was noticed in the control treated animals.…”

Biofabricated zinc oxide nanoparticles impair cognitive function via modulating oxidative stress and acetylcholinesterase level in mice

“…ZnOTP were evaluated for its in vitro antioxidant activity by ABTS method which indicates the strong antioxidant ability of ZnOTP to quench the ABTS free radical cation in a concentration‐dependent manner with IC 50 value 17.87 μg/mL. Our previous study suggested that TP leaves extract is enriched with phenolic and flavonoid compounds and it exhibited significant antioxidant activity 34 . The antioxidant effect of ZnOTP may be credited to formation of electrostatic bond between positively charged ZnONP, that is, ZnO = Zn 2+ + O 2− , and functional groups of negatively charged secondary metabolites, that is, COO − , O − .…”

“…TP has been explored for possessing various therapeutic properties against different ailments, that is, migraine, rheumatism, liver and kidney disease, inflammation, diabetes, wound healing and cognitive impairment. [32][33][34][35] Numerous bioactive secondary metabolites are reported to exist in TP such as alkaloids, phenolic compounds, flavonoids, terpenes, steroidal saponins, etc. 36 Considering the neuroprotective potential of TP, the key objective of the current study was to biofabricate, evaluate and explore the effect of TP leaves extract mediated ZnO nanoparticles (ZnOTP) on spatial cognitive behavior and insights into the possible underlying mechanism of action by estimation of zinc content, oxidative stress as well as neurotransmitters level in mice brain.…”

“…People from Asian countries utilize TP leaves as a culinary purpose as it has high nutritional content. TP has been explored for possessing various therapeutic properties against different ailments, that is, migraine, rheumatism, liver and kidney disease, inflammation, diabetes, wound healing and cognitive impairment 32‐35 . Numerous bioactive secondary metabolites are reported to exist in TP such as alkaloids, phenolic compounds, flavonoids, terpenes, steroidal saponins, etc 36 .…”

In silico Study of Trianthema portulacastrum Embedded Iron Oxide Nanoparticles on Glycogen Synthase Kinase-3β: A Possible Contributor to its Enhanced in vivo Wound Healing Potential

“…Different parts of TP possess a variety of chemical compounds such as phenolic compounds, flavonoids, terpenoids, glycosides, steroids and alkaloids (Shivhare et al, 2012). TP has been scientifically explored to have various therapeutic activities such as antifungal, anti-inflammatory, antioxidant, hepatoprotective, wound healing, hypolipidemic, antitumor, anthelmintic, etc (Yadav et al, 2017).…”