Attenuation of glycation-induced multiple protein modifications by Indian antidiabetic plant extracts

Tupe, Rashmi S.; Kemse, Nisha G.; Khaire, Amrita; Shaikh, Shamim

doi:10.1080/13880209.2016.1228683

Cited by 30 publications

(11 citation statements)

References 51 publications

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“…G. glabra extracts exhibit up to 75% antiglycation potential. Another study reported the 69% glycation inhibition from G.glabra roots owing to the presence of triterpenoid saponin and glycyrrhizin that reduced level of advanced glycation end products (Tupe et al, 2017). Significant (p<0.05) alpha amylase inhibition ranged from 7.2 to 38.7%.…”

Section: Antidiabetic Potentialmentioning

confidence: 99%

Nutritional and therapeutic potential of Glycyrrhiza glabra L. roots

Hussain

Iqbal

2020

Asian J. Med. Biol. Res

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This study was aimed to estimate the antioxidant, anti-diabetic, anti-amnesic, anti-biofilm, thrombolytic, hemolytic, and cytotoxic effects of G. glabra root extracts for nutritive and medicinal purpose. Antioxidant, alpha amylase, antiglycation, anti-amnesic, cytotoxic, thrombolytic and antibiofilm assays were performed. In the current research, G. glabra root extracts showed significant antioxidant (80.96 mg GAE/100 g TPC, 38.96 mg CE/100 g TFC, 46% DPPH scavenging), antidiabetic (75% antiglycation, 38.7% α-amylase inhibition), anti-amnesic (5.5%), hemolytic (19.46%), thrombolytic (35.4%) and antibiofilm (72% P. multocida, 51.57% S. aureus inhibition) activities. G. glabra root extracts have remarkable activity to fight against oxidative stress, hyperglycemia, blood coagulation, bacterial growth, DNA damage and memory enhancing ability that ensure its uses in food and pharmaceutical industries. Asian J. Med. Biol. Res. June 2019, 5(4): 265-270

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Section: Antidiabetic Potentialmentioning

confidence: 99%

Nutritional and therapeutic potential of Glycyrrhiza glabra L. roots

Hussain

Iqbal

2020

Asian J. Med. Biol. Res

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“…Diabetes mellitus (DM) is one of the most deadly diseases in the world; its rate coupled with its complications increases with time in every part of the world [1]. This is a metabolic disorder that result from excessive accumulation of glucose in the blood due to either deficiency in insulin synthesis or defects in insulin receptors.…”

Section: Introductionmentioning

confidence: 99%

Comparative in vitro studies of antiglycemic potentials and molecular docking of Ageratum conyzoides L. and Phyllanthus amarus L. methanolic extracts

Oso

Olaoye

2020

SN Appl. Sci.

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These in vitro studies investigated the comparative antiglycemic properties and molecular docking of the methanolic extracts of dried leaves of Ageratum conyzoides L. and Phyllanthus amarus L. in an attempt to explore natural products that could be useful in preventing secondary complications that could arise from hyperglycaemia. The methanolic crude extracts of dried leaves of A. conyzoides (CEA) and P. amarus (CEP) were partitioned into n-butanol and aqueous extracts and glycation inhibitory potentials were investigated. The result reveals that CEA and CEP exhibited highest glycemic inhibitory potential on the activities of α-amylase, α-glucosidase and sucrase investigated. The molecular docking was done on reported identified compounds in A. conyzoides and P. amarus with α-amylase (1SMD), sucrase-isomaltase (3LPO) and α-glucosidase (3WY1). Methanol crude extracts exhibited the highest inhibitory effect with the lowest IC 50 values

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“…Researchers have demonstrated 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity, protection against DNA damage, α‐amylase inhibitory effect of the plant and anti‐inflammatory properties (nitric oxide and tumour necrosis factor‐α inhibition) . Although this plant has also been shown to have a host of beneficial biological effects, including anti‐angiogenic and antidiabetic activity as well as protection against development of cardiac hypertrophy, its effect on cell migration has not been investigated yet.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of oxidative stress and artificial wound closure in C2C12 myoblasts induced by sequential extracts of Boerhavia diffusa

Yahaya

Cordier

Steenkamp

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives Whole plants of Boerhavia diffusa L. are widely used medicine in Ghana and other tropical countries, for the treatment of wounds and other ailments. The aim of the study was to determine the ability of sequential extracts of B. diffusa to influence oxidation and wound closure in myoblast cells in vitro.Methods Sequential extracts were prepared from the whole plant using four solvents of increasing polarity (hexane, ethyl acetate, methanol and water). Cytotoxicity was determined using the sulforhodamine B staining assay, phase-contrast microscopy, plasDIC microscopy and live-dead staining. Extracts were tested for their ability to reduce 2,2 0 -azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidation and mediate cell migration after artificial wound generation in C2C12 myoblast cells using the scratch wound assay. Key findings All extracts indicated negligible cytotoxicity (IC 50 > 100 lg/ml), and microscopic evaluation showed no difference from negative controls. AAPH induced a 2.87-fold increase in reactive oxygen species compared to the negative control. Pretreatment with 100 lg/ml of the extracts reduced AAPH-induced oxidation to 1.70-fold of the untreated controls (P < 0.001). Wound closures in the methanol and water extract treatments were 18.08% and 20.76% higher than the negative control, respectively (P < 0.01). Conclusions These findings indicate that the hexane, methanol and water extracts of B. diffusa whole plant promote artificial wound healing and protection against oxidation in vitro and therefore warrant further research into its mechanisms of wound healing.

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Attenuation of glycation-induced multiple protein modifications by Indian antidiabetic plant extracts

Abstract: P. crispum, B. diffusa and T. chebula had the most potent antiglycation activity. These plant exerted noticeable antiglycation activity at different glycation modifications of albumin. These findings are important for identifying plants with potential to combat diabetic complications.

Cited by 30 publications

References 51 publications

Nutritional and therapeutic potential of Glycyrrhiza glabra L. roots

Nutritional and therapeutic potential of Glycyrrhiza glabra L. roots

Comparative in vitro studies of antiglycemic potentials and molecular docking of Ageratum conyzoides L. and Phyllanthus amarus L. methanolic extracts

Attenuation of oxidative stress and artificial wound closure in C2C12 myoblasts induced by sequential extracts of Boerhavia diffusa

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