Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart

Pan, Yong; Zhu, Guo‐Qing; Wang, Yi; Cai, Lu; Cai, Yuepiao; Hu, Jie; Li, Yilan; Yan, Yongbo; Zeng-shou, Wang; Li, Xiaokun; Wei, Tiemin; Liang, Guang

doi:10.1016/j.jnutbio.2012.03.012

Cited by 81 publications

(50 citation statements)

References 38 publications

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“…Inflammation is involved in the process of chronic renal diseases, including increasing expression levels of TNF-a, IL-6, and iNOS [9,24,25]. As Fig.…”

Section: Resveratrol Inhibits Hfd-induced Renal Inflammation and Oxidmentioning

confidence: 99%

Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway

et al. 2015

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Resveratrol (RSV) has beneficial effects on renal diseases, but its underlying mechanisms are still unclear. In the present study, we investigate the renoprotective effects of RSV on obesity-related renal diseases and clarify the potential mechanisms. Male C57BL/6J mice were fed with high-fat diet (HFD) with or without 400 mg/kg RSV treatment for 12 weeks. Feeding HFD induced renal injuries, but treating them with RSV significantly decreased glomerular volume (p < 0.05), glycogen (p < 0.01) and collagen (p < 0.05) in renal tissues. Although slightly changed body weight and fasting blood glucose, RSV attenuated renal dysfunction, including decreased levels of blood urea nitrogen (p < 0.05), urea protein (p < 0.01), and microalbuminuria (p < 0.01). Furthermore, RSV treatment markedly reduced gene expression of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and inducible nitric oxide synthase (iNOS) (all p < 0.05), 4-Hydroxynonenal expression (p < 0.01), and lipid accumulation. Mechanistically, RSV enhanced the expression of lipolytic genes, peroxisome proliferator-activated receptor (PPAR)-α (p < 0.001), carnitine palmitoyltransferase (CPT)-1 (p < 0.05), and medium-chain acyl-coenzyme A dehydrogenase (MCAD) (p < 0.01), but had no effect on lipogenic genes, PPAR-γ and sterol regulatory element-binding protein (SREBP)-1c. RSV also obviously increased renal PPAR-α protein expression (p < 0.001) and the phosphorylation of AMPK level. Collectively, these results support the therapeutic effects of RSV on high-fat diet-induced renal damages at least partially through targeting on PPAR-α signaling pathway.

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“…Inflammation is involved in the process of chronic renal diseases, including increasing expression levels of TNF-a, IL-6, and iNOS [9,24,25]. As Fig.…”

Section: Resveratrol Inhibits Hfd-induced Renal Inflammation and Oxidmentioning

confidence: 99%

Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway

et al. 2015

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“…Thus, more studies are needed to evaluate the efficacy and safety of curcumin, especially the derivative of natural active curcumin, before it can be approved for human use. We have synthesized a few novel curcumin analogs from native curcumin (29,30). Among these analogs, C66 (21,29) was found to effectively protect diabetic rats from diabetes-induced kidney injury via inhibition of renal inflammatory responses and macrophage infiltration induced by high serum glucose (29).…”

mentioning

confidence: 99%

Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression

Wang

Zhou

Sun

et al. 2014

American Journal of Physiology-Endocrinology and Metabolism

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“…It has also been found that CUR downregulated the expression of IL-8, IL-1B, MMP-8, TNF-α and acute phase proteins and hence protecting rats from paracetamol-induced cytotoxicity [17] . Two novel synthetic analogues of curcumin-C66 and B06 have been reported recently, which prevented the activation of JNK/NF-ĸB signalling by downregulating the mRNA levels of COX-2, TNF-α, IL-6, IL-1 and iNOS, therefore reducing the production of NO and TNF-α in primary peritoneal macrophages stimulated by high glucose [18,19] . [20] .…”

Section: Cur Exerts Considerable Antiinflammatory Effectmentioning

confidence: 99%

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

Moselhy¹,

Razvi²,

Hasan³

et al. 2018

pharmaceutical-sciences

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Moselhy, et al.: Multifaceted Role of CurcuminCurcumin is chemically known as diferuloylmethane, which is an important nutraceutical obtained from the yellow spice Curcuma longa. It has been used traditionally as a folklore medicine in countries like India, China and Thailand for nearly 2000 years without any prior knowledge of the mechanism of action. Cellbased studies and clinical trials that have been reported so far have provided evidence that curcumin could be effectively used as antimicrobial, anticancer, antidiabetic, antiinflammatory, antimalarial and antioxidant. There are more than 9400 articles published on this "magical molecule" till date. Furthermore, nearly 100 clinical trials have been done using curcumin, which demonstrated safety, efficacy and prophylactic activity of curcumin. On the molecular level, curcumin has shown to modulate several crucial and significantly interlinked pathways in rendering an optimistic outcome against life-threatening diseases like cancer, diabetes, lupus nephritis, and other autoimmune and neurodegenerative diseases. In this communication, the chemical structure, biological properties and possible molecular targets of curcumin have been reviewed along with some recent developments in drug delivery systems of curcumin.

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Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart

Cited by 81 publications

References 38 publications

Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway

Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway

Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression

Multifaceted Role of a Marvel Golden Molecule, Curcumin: a Review

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