Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E

Trevisi, Erminio; Grossi, Paolo; Piccioli-Cappelli, F.; Cogrossi, Simone; Bertoni, Giuseppe

doi:10.4081/ijas.2011.e61

Cited by 22 publications

(17 citation statements)

References 52 publications

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“…The lack of response between OME and CTR as it relates to APP suggest that the administration of omega-3 FA alone in late pregnancy did not exert any significant effect on the inflammatory status of cows around calving. This response does not agree with a previous experiment (Trevisi et al, 2011), in which a better inflammatory status after calving was observed with supplementation of omega-3 FA. However, the discrepancy could be partly attributed to the longer period of omega-3 FA administration (pre-and postcalving) or to the contemporaneous administration of vitamin E in Trevisi et al (2011).…”

Section: Effects Of Omega-3 Fa On the Inflammatory Status And On The contrasting

confidence: 99%

“…The decreased lipomobilization in OME cows is confirmed by the reduced concentration of BHB and the greater of glucose compared with CTR and to OMAS cows. A better postcalving energy status in cows fed a diet enriched in omega-3 FA was previously observed by Ballou et al (2009) and by Trevisi et al (2011). Conversely, Mattos et al (2004) found decreased plasma concentrations of glucose and greater BHB in cows fed omega-3 FA vs. cows fed olive oil, whereas no differences were observed in NEFA.…”

Section: Effects Of Treatments On Energy Metabolismsupporting

confidence: 59%

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Effects of the precalving administration of omega-3 fatty acids alone or in combination with acetylsalicylic acid in periparturient dairy cows1

Grossi¹,

Bertoni

Piccioli-Cappelli

et al. 2013

Journal of Animal Science

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This study investigated the effects of the administration of long chain omega-3 fatty acids (ω-3 FA) and acetylsalicylic acid (ASA) on inflammation, performance, and fertility in periparturient dairy cows. Five weeks before calving, 26 multiparous dairy cows were randomly assigned to 1 of 3 treatments: ω-3 FA (n = 9; OME), ω-3 FA and ASA (n = 9; OMAS), or palm oil (n = 8; CTR). During the last 3 wk of pregnancy, OME and OMAS groups received daily 12.0 g of fish-derived ω-3 FA, whereas CTR cows received only SFA. In addition, OMAS cows received daily 6.0 mg ASA/kg BW starting at 7 d before calving. Only a few cows had health problems after calving, but those in OMAS were most affected (n = 3 vs. 1 in CTR). Inflammatory status around calving did not improve in OME cows, as confirmed by the patterns of concentration of acute-phase proteins (APP), which were similar to CTR. Compared with CTR and OME, the increase of the positive APP and the decrease of the negative APP (e.g., albumin; P < 0.01) observed in OMAS cows suggested a severe inflammatory status after calving. Compared with OMAS, postcalving energy metabolism was better in OME cows as shown by a lower degree of lipomobilization (smaller BCS drop, greater glucose) and milder ketogenesis (less β-hydroxybutyrate; P < 0.01). Cows in CTR had optimal fertility indices, whereas OMAS was the worst group. The severe inflammation and the more negative energy balance likely contributed to the poor fertility parameters in those cows. It is known that ASA exerts an inhibitory effect on cyclooxygenases, causing a possible decrease in the synthesis of PGF2α. A decreased concentration of PGF2α is connected with alterations in the physiologic processes related to labor and to uterine motility. Cows in OMAS had a longer pregnancy (P < 0.10 vs.OME) and a greater frequency of retained placenta, which may be attributed to decreased synthesis of PGF2α. The administration of ω-3 FA alone did not delay calving or the expulsion of fetal membranes. In conclusion, long-chain ω-3 FA improved the physiological status of cows, partly through better energy balance. The administration of ASA before calving (even at a low dose) in combination with ω-3 FA did not exert any synergistic positive effect on inflammation and performance.

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Section: Effects Of Omega-3 Fa On the Inflammatory Status And On The contrasting

confidence: 99%

Section: Effects Of Treatments On Energy Metabolismsupporting

confidence: 59%

Effects of the precalving administration of omega-3 fatty acids alone or in combination with acetylsalicylic acid in periparturient dairy cows1

Grossi¹,

Bertoni

Piccioli-Cappelli

et al. 2013

Journal of Animal Science

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“…We found few differences in the plasma concentrations of biomarkers of inflammation and oxidative stress with our feed restriction-induced NNB, which is contrary to work with periparturient cows (Bertoni et al, 2008). Increases in FRAP and retinol are positively associated with antioxidant activity (Benzie and Strain, 1996;Trevisi et al, 2011), whereas nitric oxide increases are associated with greater inflammation and oxidative stress (Trevisi et al, 2013). Therefore, the changes in FRAP, retinol, and nitric oxide indicate that our feed restriction model did induce some oxidative stress.…”

Section: Biomarkers Of Inflammation and Oxidative Stresscontrasting

confidence: 61%

Choline supply during negative nutrient balance alters hepatic cystathionine β-synthase, intermediates of the methionine cycle and transsulfuration pathway, and liver function in Holstein cows

Coleman

Alharthi

Lopreiato

et al. 2019

Journal of Dairy Science

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Although choline requirements for cows are unknown, enhanced postruminal supply may decrease liver triacylglycerol and increase flux through the Met cycle to improve immunometabolic status during a negative nutrient balance (NNB). Our objectives were to investigate the effects of postruminal choline supply during a feed restriction-induced NNB on (1) hepatic activity cystathionine β-synthase and transcription of enzymes in the transsulfuration pathway and Met cycle; (2) hepatic metabolites in the Met cycle and the transsulfuration pathway, bile acids, and energy metabolism; and 3) plasma biomarkers of liver function, inflammation, and oxidative stress. Ten primiparous rumencannulated Holstein cows (158 ± 24 d postpartum) were used in a replicated 5 × 5 Latin square design with 4-d treatment periods and 10 d of recovery (14 d/period). Treatments were unrestricted intake with abomasal infusion of water, restricted intake (R; 60% of net energy for lactation requirements) with abomasal infusion of water, or R plus abomasal infusion of 6.25, 12.5, or 25 g/d choline ion. Liver tissue was collected on d 5 after infusions ended, and blood was collected on d 1, 3, and 5. Statistical contrasts were A0 versus R0 (CONT1), R versus the average of choline doses (CONT2), and tests of linear and quadratic effects of choline dose. Activity of cystathionine β-synthase was lower with R (CONT1) and decreased linearly with choline. Hepatic glutathione was not different with R or choline, but taurine tended to be greater with choline (CONT2). Betaine and carnitine were greater with R (CONT1) and further increased with choline (CONT2). Concentrations of NAD + were greater with choline (CONT2). Cholic and glycol-chenodeoxycholic acids were decreased by R and choline, while taurocholic and tauro-chenodeoxycholic acids were not altered. Plasma aspartate aminotransferase and bilirubin were greater with R (CONT1) but decreased with choline (CONT2). Paraoxonase was lower with R and increased with choline (CONT2). Data suggest that enhanced supply of choline during NNB decreases entry of homocysteine to the transsulfuration pathway, potentially favoring remethylation to Met by acquiring a methyl group from betaine. As such, Met may provide methyl groups for synthesis of carnitine. Along with production data indicating that 12.5 g/d choline ion improved milk yield and liver fatty acid metabolism during NNB, the changes in blood biomarkers also suggest a beneficial effect of choline supply on liver function and oxidative stress.

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“…This marked decrease in the concentration of haptoglobin by d 21 postpartum in ethyl-cellulose RPM-supplemented cows indicates they were able to better control the inflammatory response. Additionally, the higher concentration of plasma albumin, as well as cholesterol and paraoxonase, which are also biomarkers of anti-inflammatory responses, in ethyl-cellulose RPM cows supports the idea that they were under a less pronounced inflammatory state (Trevisi et al, 2011;Grossi et al, 2013). Myeloperoxidase tended (P = 0.15) to be higher in the ethyl-cellulose RPM group compared with control cows.…”

Section: Biomarkers Of Inflammationsupporting

confidence: 53%

“…These results partly reflect the greater DMI in RPM cows during the postpartum period (Batistel et al, 2017). The greater concentrations of those vitamins, together with greater plasma concentration of FRAP, is positively associated with antioxidant activity (Benzie and Strain, 1996;Trevisi et al, 2011). Retinol concentration was not different between groups (P = 0.18).…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 84%

Ethyl-cellulose rumen-protected methionine alleviates inflammation and oxidative stress and improves neutrophil function during the periparturient period and early lactation in Holstein dairy cows

Batistel

Arroyo

Garcés

et al. 2018

Journal of Dairy Science

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The periparturient period is the most critical phase in the productive cycle of dairy cows and is characterized by impairment of the immune system. Our objective was to evaluate the effect of feeding ethyl-cellulose rumen-protected methionine (RPM) starting at d -28 from expected parturition through 60 d in milk on biomarkers of inflammation, oxidative stress, and liver function as well as leukocyte function. Sixty multiparous Holstein cows were used in a block design and assigned to either a control or the control plus ethyl-cellulose RPM (Mepron, Evonik Nutrition & Care GmbH). Mepron was supplied from -28 to 60 d in milk at a rate of 0.09% and 0.10% dry matter during the prepartum and postpartum period. That rate ensured that the ratio of Lys to Met in the metabolizable protein was close to 2.8:1. Blood samples from 15 clinically healthy cows per treatment were collected at d -30, -14, 1, 7, 21, 30, and 60 and analyzed for biomarkers of liver function, inflammation, and oxidative stress. Neutrophil and monocyte function in whole blood was measured in vitro at -14, 1, 7, 21, and 30 d in milk. The statistical model included the random effect of block and fixed effect of treatment, time, and its interaction. Compared with control, ethyl-cellulose RPM increased plasma cholesterol and paraoxonase after parturition. Among the inflammation biomarkers measured, ethyl-cellulose RPM led to greater albumin (negative acute-phase protein) and lower haptoglobin than control cows. Although concentration of IL-1β was not affected by treatments, greater IL-6 concentration was detected in response to ethyl-cellulose RPM. Cows supplemented with ethyl-cellulose RPM had greater plasma concentration of ferric-reducing antioxidant power, β-carotene, tocopherol, and total and reduced glutathione, whereas reactive oxygen metabolites were lower compared with control cows. Compared with control, ethyl-cellulose RPM enhanced neutrophil phagocytosis and oxidative burst. Overall, the results indicate that ethyl-cellulose RPM supply to obtain a Lys-to-Met ratio of 2.8:1 in the metabolizable protein during the periparturient period and early lactation is an effective approach to help mitigate oxidative stress and inflammation as well as enhance liver and neutrophil function in dairy cows.

show abstract

Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E

Abstract: The aim of this research was to study the consequences of ω3 fatty acids (FA) administration around calving on inflammatory response and on productive performances.

Cited by 22 publications

References 52 publications

Effects of the precalving administration of omega-3 fatty acids alone or in combination with acetylsalicylic acid in periparturient dairy cows1

Effects of the precalving administration of omega-3 fatty acids alone or in combination with acetylsalicylic acid in periparturient dairy cows1

Choline supply during negative nutrient balance alters hepatic cystathionine β-synthase, intermediates of the methionine cycle and transsulfuration pathway, and liver function in Holstein cows

Ethyl-cellulose rumen-protected methionine alleviates inflammation and oxidative stress and improves neutrophil function during the periparturient period and early lactation in Holstein dairy cows

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