Attenuation of low-grade chronic inflammation by phytonutrients: A computational systems biology analysis

Ayyadurai, V. A. Shiva; Deonikar, Prabhakar; Bannuru, Raveendhara R.

doi:10.1016/j.clnesp.2022.03.010

Cited by 6 publications

(10 citation statements)

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“…The workflow for the identification, organization, and curation of the literature and the extraction of information from the literature was performed per the standardized CytoSolve ® protocol detailed in previous studies [ 29 , 30 , 31 ]. The specific list of Medical Subject Headings (MeSH) keywords is provided in File S3 in Supplementary Materials Section S3.1 .…”

Section: Methodsmentioning

confidence: 99%

“…The identification and extraction of data related to reaction rate constants, biochemical reactions, and pharmacokinetic properties of GA with respect to the molecular pathways of liver detoxification were performed per the standardized CytoSolve ® protocol detailed in previous studies [ 29 , 30 , 31 ]. All biochemical reactions for each of the individual liver detoxification mathematical models, along with the kinetic parameters and the initial concentration of biochemical species, are listed in Supplementary File S2 in Tables S2.1–S2.4 .…”

Section: Methodsmentioning

confidence: 99%

“…Molecular pathways of liver detoxification are converted into individual mathematical models using the biochemical reactions per the standardized CytoSolve ® protocol detailed in previous studies [ 29 , 30 , 31 ]. The individual mathematical models were integrated using the standardized CytoSolve ® protocol detailed in previous studies [ 29 , 30 , 31 ].…”

Section: Methodsmentioning

confidence: 99%

“…The effect of GA was assessed by estimating the cellular concentration levels of biomarkers of these processes such as cPARP, reactive oxygen species, deconjugates, and β-glucuronidase, respectively, in the presence and absence of the GA. The integrated model of detoxification was simulated using the standardized CytoSolve ® protocol detailed in previous studies [ 29 , 30 , 31 ].…”

Section: Methodsmentioning

confidence: 99%

“…The study herein employs CytoSolve, a proven computational systems biology approach to: (1) identify potential molecular mechanisms involved in liver detoxification affected by GA; and (2) quantitatively predict the effect of GA in aiding liver detoxification. Previous work has demonstrated the viability of using such a computational systems biology approach to model complex biomolecular phenomena [ 23 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Mechanistic Understanding of D-Glucaric Acid to Support Liver Detoxification Essential to Muscle Health Using a Computational Systems Biology Approach

Ayyadurai¹,

Deonikar²,

Fields³

2023

Nutrients

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Liver and muscle health are intimately connected. Nutritional strategies that support liver detoxification are beneficial to muscle recovery. Computational–in silico–molecular systems’ biology analysis of supplementation of calcium and potassium glucarate salts and their metabolite D-glucaric acid (GA) reveals their positive effect on mitigation of liver detoxification via four specific molecular pathways: (1) ROS production, (2) deconjugation, (3) apoptosis of hepatocytes, and (4) β-glucuronidase synthesis. GA improves liver detoxification by downregulating hepatocyte apoptosis, reducing glucuronide deconjugates levels, reducing ROS production, and inhibiting β-Glucuronidase enzyme that reduces re-absorption of toxins in hepatocytes. Results from this in silico study provide an integrative molecular mechanistic systems explanation for the mitigation of liver toxicity by GA.

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Section: Methodsmentioning

confidence: 99%