Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation

Rithidech, Kanokporn Noy; Tungjai, Montree; Reungpatthanaphong, Paiboon; Honikel, Louise; Simon, Sanford R.

doi:10.1016/j.mrgentox.2012.08.001

Cited by 46 publications

(24 citation statements)

References 66 publications

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“…Lowered the levels of TNF-a, IL-1b, and IL-6 in gamma-irradiated mice [162]. Attenuated TNF-a-induced VCAM-1 mRNA and protein expression in hypertensive rats [163].…”

Section: Isoliquiritigeninmentioning

confidence: 95%

See 1 more Smart Citation

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

Gupta

Tyagi

Deshmukh-Taskar

et al. 2014

Archives of Biochemistry and Biophysics

280

172

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“…Lowered the levels of TNF-a, IL-1b, and IL-6 in gamma-irradiated mice [162]. Attenuated TNF-a-induced VCAM-1 mRNA and protein expression in hypertensive rats [163].…”

Section: Isoliquiritigeninmentioning

confidence: 95%

“…Resveratrol (3,4 0 ,5-trihydroxy-trans-stilbene) was originally 162 isolated in 1940 as an ingredient of the roots of white hellebore 163 (Veratrum grandiflorum O. Loes). To date, this polyphenol has been 164 identified in extracts from more than 70 other plant species [40], 165 the major source being red wine.…”

mentioning

confidence: 99%

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

Gupta

Tyagi

Deshmukh-Taskar

et al. 2014

Archives of Biochemistry and Biophysics

280

172

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“…It was previously reported that apigenin also possessed remarkable antioxidant, anti-carcinogenic, and estrogenic properties [15][16][17][18][19]. A study by Bandyopadhyay et al showed that apigenin had a potent anti-osteoclastogenic effect through its action on osteoblasts, preadipocytes, and osteoclasts [20].…”

Section: Introductionmentioning

confidence: 99%

Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways

et al. 2015

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Apigenin is a plant-derived flavonoid and has been reported to prevent bone loss in ovariectomized mice, but the role of apigenin on osteogenic differentiation of human mesenchymal stem cells (hMSCs) has not been reported. In the present study, the effect of apigenin on osteogenic differentiation of hMSCs was explored. Our results showed that apigenin treatment significantly increased alkaline phosphatase (ALP) activity and mineralization in hMSCs. RT-PCR revealed that apigenin markedly up-regulated the mRNA expression of osteopontin (OPN) and the transcription factors runt-related transcription factor 2 (Runx2). The expression of Runx2 and osterix (OSX) proteins were also increased in hMSCs differentiating into osteoblasts after treatment with apigenin. Furthermore, we investigated the signaling pathways responsible for osteogenic differentiation of apigenin in hMSCs. We found that apigenin treatment significantly increased the levels of p-JNK, p-p38 in hMSCs and addition of the inhibitors of JNK (SP600125) or p38 MAPK (SB203580) eliminated the stimulating effects of apigenin. In addition, addition of SP600125 or SB203580 also blocked apigenin-induced ALP activity, OPN, Runx2, and OSX expression and meanwhile inhibited bone nodule formation. Taken together, these findings suggest apigenin promotes the osteogenesis of hMSCs through activation of JNK and p38 MAPK signal pathways which leads to Runx2 and OSX expressions to induce the formation of bone nodule.

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“…Singh et al reported that 50 mg/kg body weight of apigenin caused no changes in serum biomarkers (alanine amino transferase, aspartate amino transferase, and alkaline phosphatase) of hepatotoxicity at 48 hours after intraperitoneal injection in Swiss mice [60]. Likewise, no sign of illness was observed in mice after 10 days of single intraperitoneal injection of 40 mg/kg body weight of apigenin [61]. However, apigenin at dosage of 10 mg/kg body weight significantly inhibits cytokines such as TNF, IL-1 and IL-6 expression in vivo [61].…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, no sign of illness was observed in mice after 10 days of single intraperitoneal injection of 40 mg/kg body weight of apigenin [61]. However, apigenin at dosage of 10 mg/kg body weight significantly inhibits cytokines such as TNF, IL-1 and IL-6 expression in vivo [61]. In the present, our results indicated that a lower dose (1.23 mg/kg body weight) apigenin could improve acute dermatoses and topical applications of apigenin at dosage of 4 mg/kg body weight per day for 7 days could relieve subacute dermatitis.…”

Section: Discussionmentioning

confidence: 99%

Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models

Man

Hupe

Sun

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Herbal medicines have been used in preventing and treating skin disorders for centuries. It has been demonstrated that systemic administration of chrysanthemum extract exhibits anti-inflammatory properties. However, whether topical applications of apigenin, a constituent of chrysanthemum extract, influence cutaneous inflammation is still unclear. In the present study, we first tested whether topical applications of apigenin alleviate cutaneous inflammation in murine models of acute dermatitis. The murine models of acute allergic contact dermatitis and acute irritant contact dermatitis were established by topical application of oxazolone and phorbol 12-myristate 13-acetate (TPA), respectively. Inflammation was assessed in both dermatitis models by measuring ear thickness. Additionally, the effect of apigenin on stratum corneum function in a murine subacute allergic contact dermatitis model was assessed with an MPA5 physiology monitor. Our results demonstrate that topical applications of apigenin exhibit therapeutic effects in both acute irritant contact dermatitis and allergic contact dermatitis models. Moreover, in comparison with the vehicle treatment, topical apigenin treatment significantly reduced transepidermal water loss, lowered skin surface pH, and increased stratum corneum hydration in a subacute murine allergic contact dermatitis model. Together, these results suggest that topical application of apigenin could provide an alternative regimen for the treatment of dermatitis.

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Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation

Cited by 46 publications

References 66 publications

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols

Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways

Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models

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