Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis

Hepatopreventive properties of hydroxytyrosol and mannitol-rich extracts obtained from exhausted olive pomace using green extraction methods

“…21 The observed liver damage could be due to altered membrane permeability and/or hepatocyte necrosis. 38 The present finding confirmed this hypothesis and revealed remarkable injuries of the hepatic tissue, including dilatation of sinusoids, congestion of the centrilobular vein, leukocyte infiltration, and vacuolization of hepatocytes. The obtained data were in accordance with those shown by Unanma et al 39 who mentioned liver damage during CCl 4 treatment in rats.…”

Unlocking the hepatoprotective potential of the parasitic plant Orobanche foetida Poir. aqueous extract against CCl4-induced liver injury in rat

“…In vivo experiments showed that the biomarkers (AST, ALT, LDH, ALP, Bilirubin, and GGT) amounts were significantly increased after CCl 4 treatment, aligned with the previous results of Tlili et al (2018). As reported by Wali et al (2021), these biomarkers suggest that liver injury may be due to altered membrane permeability and/or hepatocyte necrosis. Our current study confirmed this hypothesis and demonstrated extensive damage to liver tissue, including necrotic cells, centrilobular venous occlusion, leukocyte infiltration, and Kupffer cell proliferation.…”

“…This CCl 3 ∗ radical interacts with reactive oxygen species (ROS), leading to the generation of another radical known as trichloromethyl peroxyl radical (OOCCl 3 ∗). The presence of the two radicals CCl 3 ∗ and OOCCl 3 ∗ contributes to an increase in oxidative stress, triggering various pathways including lipid peroxidation ( Erdaş et al, 2021 ), disruption of the glutathione pathway ( Bikheet et al, 2022 ) and the production of pro-inflammatory cytokines, specifically TNF-α ( Devi et al, 2021 ) and IL-6 ( Wali et al, 2021 ). These cumulative effects ultimately contribute to liver damage.…”