Attenuation of perseverative behavior after repeated amphetamine treatment: Tolerance or attentional deficits?

Bruto, Venera; Kokkinidis, Larry; Anisman, Hymie

doi:10.1016/0091-3057(83)90126-0

Cited by 12 publications

(3 citation statements)

References 12 publications

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“…However, this experimental group still demonstrated impaired retention when compared with saline-treated animals. These results are in line with other studies showing that repeated treatment with amphetamine, or methamphetamine, induces performance impairments in learning/memory animal models (Bruto et al 1983;Yamamura et al 1992). Accordingly, amphetamine abusers have been reported to present several kinds of memory impairment, considered to be a result of amphetamine neurotoxicity (McKetin and Mattick 1998;Ornstein et al 2000).…”

Section: Discussionsupporting

confidence: 91%

“…Other studies, however, show different profiles of amphetamine effects on learning/memory, such as absence of effect (Fulginiti and Cancela 1983;Beuzen et al 1994) or even impaired performance (Bruto et al 1983;Gutnikov et al 1994;McKetin and Mattick 1998;Ornstein et al 2000). These several studies, of course, show different protocols of amphetamine administration.…”

Section: Introductionmentioning

confidence: 87%

“…These several studies, of course, show different protocols of amphetamine administration. In some of them, the drug was acutely administered after the training session (Castellano 1973;Janak and Martinez 1992), in others administration of the drug was conducted before the training session (Roffman and Lal 1971;Fulginiti and Cancela 1983;Ventulani et al 1993;Beuzen et al 1994;Gutnikov et al 1994;Roozendaal et al 1996), and, in some, the effects of amphetamine were observed after different kinds of repeated treatment (Bruto et al 1983;McKetin and Mattick 1998;Ornstein et al 2000).…”

Section: Introductionmentioning

confidence: 99%

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Effects of amphetamine on the plus-maze discriminative avoidance task in mice

et al. 2002

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Amphetamine has different effects on DAT when given pre- or post-training. While acute pre-training amnestic action is temporally correlated with an anxiogenic effect, there is tolerance to the anxiogenic but not to the amnestic effect after repeated administration. Because this acute amnestic effect of amphetamine is attenuated by tacrine, a possible relationship with cholinergic system cannot be discarded as a mechanism to amphetamine-induced amnesia in DAT.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Effects of amphetamine on the plus-maze discriminative avoidance task in mice

et al. 2002

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Modular Disjunction in Schizophrenia: A Framework for a Pathological Psychophysiology

Cleghorn¹,

Albert²

1990

International Perspectives Series: Psychiatry, Psychology, and Neuroscience

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Amphetamine-induced perseverative behavior in a radial arm maze following DSP4 or 6-OHDA pretreatemnt

1984

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Mice permitted to explore an 8-arm radial maze tended to visit those arms least recently entered. Treatment with D-amphetamine engendered a perseverative tendency, wherein mice repeatedly visited two arms of the maze. Administration of the norepinephrine (NE) neurotoxin, N-2-chloroethyl-N-ethyl-2-bromo-benzylamine (DSP4), appreciably reduced NE in the hippocampus and cortex, moderately reduced NE in the locus coeruleus, and had only a small effect on hypothalamic NE. The DSP4 treatment resulted in a decrease of locomotor activity among amphetamine-treated mice, coupled with an increase of stereotyped response patterns. Although the NE depletion did not affect the pattern of exploration that mice ordinarily displayed, DSP4 appreciably increased the perseverative tendency provoked by amphetamine. Reduction of dopamine (DA) and NE by intraventricular administration of the catecholamine neurotoxin, 6-hydroxydopamine (6-OHDA), antagonized the effects of amphetamine, such that the frequency of alternation responses was increased and the proportion of perseverative responses was reduced. The effectiveness of the 6-OHDA treatment in antagonizing the amphetamine-induced perseveration was not reduced among mice that were pretreated with desmethylimipramine, which resulted in partial prevention of the NE reduction by 6-OHDA administration. It is suggested that DA neuronal activity contributes to the amphetamine -provoked perseveration , whereas NE stimulation modifies the perseverative tendency by influencing exploration or habituation.

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Attenuation of perseverative behavior after repeated amphetamine treatment: Tolerance or attentional deficits?

Cited by 12 publications

References 12 publications

Effects of amphetamine on the plus-maze discriminative avoidance task in mice

Effects of amphetamine on the plus-maze discriminative avoidance task in mice

Modular Disjunction in Schizophrenia: A Framework for a Pathological Psychophysiology

Amphetamine-induced perseverative behavior in a radial arm maze following DSP4 or 6-OHDA pretreatemnt

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