Attenuation of transplant arteriosclerosis by oral feeding of major histocompatibility complex encoding chitosan-DNA nanoparticles

Goldmann, K; Hoffmann, Julia; Eckl, S.; Spriewald, Bernd M.; Ensminger, Stephan

doi:10.1016/j.trim.2012.11.007

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Contrary findings are apparent, however 332,333 , and targeted delivery of protein antigen directly to Peyer's patches via M cells has been shown to facilitate tolerance induction 230 . Similarly, oral antigen delivery in liposomes 231 , nanoparticles 232,233 and microspheres 234 appear to enhance tolerance, although the mechanisms involved are not well understood.…”

Section: Tolerancementioning

confidence: 99%

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

Trevaskis

Kaminskas

Porter

2015

Nat Rev Drug Discov

538

496

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The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of metastasis, and recent studies have suggested intrinsic links between lymphatic function, lipid deposition, obesity and atherosclerosis. Advances in the current understanding of the role of the lymphatics in pathological change and immunity have driven the recognition that lymph-targeted delivery has the potential to transform disease treatment and vaccination. In addition, the design of lymphatic delivery systems has progressed from simple systems that rely on passive lymphatic access to sophisticated structures that use nanotechnology to mimic endogenous macromolecules and lipid conjugates that 'hitchhike' onto lipid transport processes. Here, we briefly summarize the lymphatic system in health and disease and the varying mechanisms of lymphatic entry and transport, as well as discussing examples of lymphatic delivery that have enhanced therapeutic utility. We also outline future challenges to effective lymph-directed therapy.

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Section: Tolerancementioning

confidence: 99%

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

Trevaskis

Kaminskas

Porter

2015

Nat Rev Drug Discov

538

496

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“…However, the use of NPs in transplantation is still an emerging concept and in its infancy with very few descriptions in the current literature. [20][21][22] The attraction of NPs is, in large part, attributed to their unique physiochemical properties, such as their small size, stability and the ability for tailoring with various functionalities. In addition, the large functional surface on a NP is able to attach biomarkers and proteins.…”

Section: Introductionmentioning

confidence: 99%

Immunosuppressive nano-therapeutic micelles downregulate endothelial cell inflammation and immunogenicity

et al. 2015

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In this study, we developed a stable, nontoxic novel micelle nanoparticle to attenuate responses of endothelial cell (EC) inflammation when subjected to oxidative stress, such as observed in organ transplantation. Targeted Rapamycin Micelles (TRaM) were synthesized using PEG-PE-amine and N-palmitoyl homocysteine (PHC) with further tailoring of the micelle using targeting peptides (cRGD) and labeling with far-red fluorescent dye for tracking during cellular uptake studies. Our results revealed that the TRaM was approximately 10 nm in diameter and underwent successful internalization in Human Umbilical Vein EC (HUVEC) lines. Uptake efficiency of TRaM nanoparticles was improved with the addition of a targeting moiety. In addition, our TRaM therapy was able to downregulate both mouse cardiac endothelial cell (MCEC) and HUVEC production and release of the pro-inflammatory cytokines, IL-6 and IL-8 in normal oxygen tension and hypoxic conditions. We were also able to demonstrate a dose-dependent uptake of TRaM therapy into biologic tissues ex vivo. Taken together, these data demonstrate the feasibility of targeted drug delivery in transplantation, which has the potential for conferring local immunosuppressive effects without systemic consequences while also dampening endothelial cell injury responses.

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Genetically modified immunomodulatory cell-based biomaterials in tissue regeneration and engineering

Jiang

Zhu

et al. 2022

Cytokine & Growth Factor Reviews

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Attenuation of transplant arteriosclerosis by oral feeding of major histocompatibility complex encoding chitosan-DNA nanoparticles

Cited by 5 publications

References 33 publications

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

Immunosuppressive nano-therapeutic micelles downregulate endothelial cell inflammation and immunogenicity

Genetically modified immunomodulatory cell-based biomaterials in tissue regeneration and engineering

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