Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats

Sharma, Bhupesh; Singh, Nirmal

doi:10.1007/s00213-011-2164-0

Cited by 90 publications

(49 citation statements)

References 71 publications

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“…These findings imply the unique anti-oxidative effect of butyrate. In fact, butyrate beneficially influences oxidative stress in the colon of healthy humans [38], [39], in addition to alleviating oxidative stress induced by lipopolysaccharide in the intestinal cells [40] or streptozotocin diabetic rats [41], by changing the number of genes that is involved in radical scavenging [33], [39].…”

Section: Discussionmentioning

confidence: 99%

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

et al. 2014

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In this study, we evaluated the effect of replacing dietary fiber with sodium butyrate on reproductive performance and antioxidant defense in a high fat diet during pregnancy by using a rat model. Eighty virgin female Sprague Dawley rats were fed one of four diets—(1) control diet (C group), (2) high fat + high fiber diet (HF group), (3) high-fat +5% sodium butyrate diet (SB group), and (4) HF diet + α-cyano-4-hydroxy cinnamic acid (CHC group)—intraperitoneally on days 8, 10, 12, 14, and 16 of gestation. SB and dietary fiber had similar effects on improving fetal number and reducing the abortion rate; however, the anti-oxidant capacity of maternal serum, placenta, and fetus was superior in the HF group than in the SB group. In comparison, CHC injection decreased reproductive performance and antioxidant defense. Both dietary fiber (DF) and SB supplementation had a major but different effect on the expression of anti-oxidant related genes and nutrient transporters genes. In summary, our data indicate that SB and DF showed similar effect on reproductive performance, but SB cannot completely replace the DF towards with respect to redox regulation in high-fat diet; and SB might influence offspring metabolism and health differently to DF.

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Section: Discussionmentioning

confidence: 99%

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

et al. 2014

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“…Analysis of serum homocysteine concentration was conducted on 1 st day of the study before L-methionine treatment and on the 52 nd day of the study before exposure on the Morris water maze. Behavioral and other assessments were done on the 52 nd day of L-methionine treatment [3]. HPLC system was additionally used to measure levels of homocysteine.…”

Section: Methodsmentioning

confidence: 99%

“…Dementia of vascular origin (VaD) has gained much attention in the past years for being the second most common type of dementia after Alzheimer's disease (AD) [2,3]. It was estimated that 35.6 million people lived with dementia worldwide in 2010, with numbers expected to almost double every 20 years, to 65.7 million in 2030 and 115.4 million in 2050 [4].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of a Selective Endothelin ET_AReceptor Antagonist in Rat Model of L-Methionine-induced Vascular Dementia

Mangat

Jaggi

Singh

2014

Korean J Physiol Pharmacol

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The present study was designed to investigate the efficacy of selective ETA receptor antagonist, ambrisentan on hyperhomocysteinemia-induced experimental vascular dementia. L-methionine was administered for 8 weeks to induce hyperhomocysteinemia and associated vascular dementia in male rats. Ambrisentan was administered to L-methionine-treated effect rats for 4 weeks (starting from 5th to 8th week of L-methionine treatment). On 52nd day onward, the animals were exposed to the Morris water maze (MWM) for testing their learning and memory abilities. Vascular endothelial function, serum nitrite/nitrate levels, brain thiobarbituric acid reactive species (TBARS), brain reduced glutathione (GSH) levels, and brain acetylcholinesterase (AChE) activity were also measured. L-methionine-treated animals showed significant learning and memory impairment, endothelial dysfunction, decrease in/serum nitrite/nitrate and brain GSH levels along with an increase in brain TBARS levels and AChE activity. Ambrisentan significantly improved hyperhomocysteinemia-induced impairment of learning, memory, endothelial dysfunction, and changes in various biochemical parameters. These effects were comparable to that of donepezil serving as positive control. It is concluded that ambrisentan, a selective ETA receptor antagonist may be considered as a potential pharmacological agent for the management of hyperhomocysteinemia-induced vascular dementia.

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“…Butyrate is the primary energy source for the colonic epithelium and is recognized for numerous health-promoting benefits (Donohoe et al, 2011;Grootaert et al, 2011;Hu et al, 2010;Rawluszko et al, 2011;Sharma and Singh, 2011). Butyrateproducing taxa, such as Butyrivibrio spp.…”

Section: Potential Health Consequencesmentioning

confidence: 99%

Habitat degradation impacts black howler monkey (Alouatta pigra) gastrointestinal microbiomes

et al. 2013

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The gastrointestinal (GI) microbiome contributes significantly to host nutrition and health. However, relationships involving GI microbes, their hosts and host macrohabitats remain to be established. Here, we define clear patterns of variation in the GI microbiomes of six groups of Mexican black howler monkeys (Alouatta pigra) occupying a gradation of habitats including a continuous evergreen rainforest, an evergreen rainforest fragment, a continuous semi-deciduous forest and captivity. High throughput microbial 16S ribosomal RNA gene sequencing indicated that diversity, richness and composition of howler GI microbiomes varied with host habitat in relation to diet. Howlers occupying suboptimal habitats consumed less diverse diets and correspondingly had less diverse gut microbiomes. Quantitative real-time PCR also revealed a reduction in the number of genes related to butyrate production and hydrogen metabolism in the microbiomes of howlers occupying suboptimal habitats, which may impact host health.

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Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats

Abstract: Sodium butyrate may be considered as potential pharmacological agent for the management of diabetes induced vascular dementia.

Cited by 90 publications

References 71 publications

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

Ameliorative Effect of a Selective Endothelin ET_AReceptor Antagonist in Rat Model of L-Methionine-induced Vascular Dementia

Habitat degradation impacts black howler monkey (Alouatta pigra) gastrointestinal microbiomes

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Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats

Abstract: Sodium butyrate may be considered as potential pharmacological agent for the management of diabetes induced vascular dementia.

Cited by 90 publications

References 71 publications

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

Use of Sodium Butyrate as an Alternative to Dietary Fiber: Effects on the Embryonic Development and Anti-Oxidative Capacity of Rats

Ameliorative Effect of a Selective Endothelin ETAReceptor Antagonist in Rat Model of L-Methionine-induced Vascular Dementia

Habitat degradation impacts black howler monkey (Alouatta pigra) gastrointestinal microbiomes

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Ameliorative Effect of a Selective Endothelin ET_AReceptor Antagonist in Rat Model of L-Methionine-induced Vascular Dementia