The purpose of this study is to evaluate in vitro the effect of an aqueous extract of Urtica dioica on the dissolution of oxalocalcic type kidney stones at the mesoscopic scale. The weight of the stones used in our experiment varied from: 0.0625g to 1.1049g. Type identification of kidney stone samples is performed by Infrared spectroscopic analysis. The presence of carboxylate ion of calcium oxalate is highlighted by absorption bands in the 1312.41 cm -1 and 1606.36 cm -1 areas. The aqueous extract of the aerial part of the plant Urtica dioica was prepared by infusion for 30 min of 5g of powder in 100 ml of saline solution (9 g/L of NaCl), previously brought to the boiling point, and there was then filtered. The stones were left in contact with the extract for 6 weeks, under constant magnetic stirring in 50 ml of aqueous extract. Kinetic evolution of the pH and the evaluation of the dissolution capacity of the extracts were carried out every week. The results obtained are very satisfactory where we observe a loss of mass which increases with time in order to reach a rate of 63%. This confirms the dissolution of stones and the increase of pH by the effect of the presence of the base of calcium oxalate in the aqueous medium. According to this study, we emphasize the need to suggest Urtica dioica as a means to reduce the occurrence of this urological disease and to establish less expensive tests and treatments.