Phytochemical analysis, antioxidant, and antihyperlipidemic activities of Teucrium takoumitense

El-Guourrami, Otman; Elbouny, Hamza; Ait Benlabchir, Abdessamad; Drioua, Soufiane; Ouahzizi, Brahim; Alem, Chakib; Doukkali, Anass; Benzeid, Hanane

doi:10.1016/j.jtumed.2023.07.011

Cited by 4 publications

(1 citation statement)

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“…Moreover, rutin was also reported in several studies to exert significant lipid-lowering effects in animals fed a HFD through the modulation of inflammation pathways (Gao et al, 2013), gut microbiota (Peng et al, 2020;Yan et al, 2022), and other cellular and molecular targets (Panchal et al, 2011;Seo et al, 2015). Furthermore, other Teucrium plants were reported to exert significant lipid-lowering effects including T. polium L. from Iran (Safaeian et al, 2018), T. takoumitense from Morocco (El-Guourrami et al, 2023), and T. leucocladumon from Palestine (Bassalat et al, 2020). According to our findings and the literature data, the proper administration of T. mideltense aqueous extract would be effective in lowering lipids under hyperlipidemic state.…”

Section: Discussionmentioning

confidence: 94%

Phytochemical study and biological activities of Teucrium mideltense (Batt.) Humbert.

ELBOUNY,

OUAHZİZİ,

BENRAHOU

et al. 2024

International Journal of Secondary Metabolite

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Teucrium mideltense (Batt.) Humbert (T. mideltense) is an endemic Moroccan species that grows exclusively in the Oriental High Atlas Mountains of Morocco. In this work, we aim at determining the chemical profile and biological properties of the traditionally used aqueous extract of this plant. HPLC analysis, estimation of the amounts of total phenolic compounds including flavonoids, and in vitro antioxidant activity was evaluated according to the literature procedures (DPPH, ABTS, and FRAP). Additionally, safety assessment was carried out according to the organization for economic cooperation and development guidelines and the anti-hyperlipidemic activity was evaluated in triton-induced hyperlipidemic rat model. Our findings revealed that the aqueous extract of this plant contains significant amounts of phenolic compounds (91.94 mg GAE/gE) including flavonoids (27.41 mg RE/gE). HPLC analysis revealed the presence of vanillic acid, hesperidin, and rutin. Moreover, a considerable in vitro antioxidant effect was evaluated (DPPH IC50 = 36.10± 0.02 μg/mL; ABTS IC50 = 34.98± 1.31 μg/mL; FRAP EC50 = 129.74±2.18 μg/mL). Furthermore, T. mideltense (Batt.) Maire extract exerted significant lipid-lowering effects by reducing the levels of total cholesterol (-88.78%), triglycerides (-62.12%), and non-HDL cholesterol (-68.37%). We conclude that the supplementation with the aqueous extract of T. mideltense would be effective in lowering lipids under hyperlipidemic conditions.

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