Attitudes, Knowledge, and Risk Perceptions of Women  With Breast and/or Ovarian Cancer Considering Testing for <i>BRCA1</i> and <i>BRCA2</i>

Bluman, Leslie G.; Rimer, Barbara K.; Berry, Donald A.; Borstelmann, Nancy; Iglehart, J. Dirk; Regan, Katherine V.; Schildkraut, Joellen M.; Winer, Eric P.

doi:10.1200/jco.1999.17.3.1040

Cited by 122 publications

(43 citation statements)

References 28 publications

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“…Having prior knowledge that our local population is not generally well informed about medical matters, we felt it important to design a questionnaire assessing only common and important knowledge of breast cancer risk factors and hereditary breast cancer using simplistic language. We have done so by collating and modifying questions used in various previous studies [25, 26, 41, 42]and hope to validate this questionnaire in future studies. Finally, our survey assessed theoretical knowledge and not actual practices.…”

Section: Discussionmentioning

confidence: 99%

The Importance of Paternal Family History in Hereditary Breast Cancer Is Underappreciated by Health Care Professionals

Yong

Zhou

Lee³

2003

Oncology

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Objectives: Cancer genetics clinics have been established in many major oncology centers worldwide in recent years. For such specialized clinics to fulfill their function, primary care physicians need to identify high-risk patients for referral. Methods: We conducted a survey to evaluate the level of awareness of breast cancer risk factors and hereditary breast cancer among health care providers and patients. Results: 284 health care professionals, 221 medical students, 104 breast cancer patients and 177 cancer-free women participated in the study. Less than half of the patients with breast cancer were aware of their risk for another breast cancer or of the increased breast cancer risk of their sisters and daughters. Less than one quarter of the health care professionals and medical students knew the importance of paternal family history in the evaluation for hereditary breast cancer. Only about half of the health care professionals and medical students and less than one third of the breast cancer patients and cancer-free women knew about genetic testing and prophylactic mastectomy as options for women at risk for hereditary breast cancer. Conclusions: Health care providers and medical students lack basic genetic knowledge and are not aware of emerging diagnostic and preventive options for hereditary breast cancer. Inclusion of cancer genetics in the continuing medical education of health care providers is important to promote such awareness.

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Section: Discussionmentioning

confidence: 99%

The Importance of Paternal Family History in Hereditary Breast Cancer Is Underappreciated by Health Care Professionals

Yong

Zhou

Lee³

2003

Oncology

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“…Interest in genetic testing has increased commensurately (Jacobs, Latza et al 2001; Dahodwala, Connolly et al 2007; Falcone, Wood et al 2011); however, a range of studies have demonstrated a lack of general (Henneman, Timmermans et al 2004; Catz, Green et al 2005) or disease-specific genetic knowledge among various patient populations including PD patients (Falcone, Wood et al 2011), breast cancer patients (Bluman, Rimer et al 1999; Bluman, Rimer et al 2003), and Huntington disease patients (Semaka, Balneaves et al 2012). …”

Section: Introductionmentioning

confidence: 99%

Knowledge of and Interest in Genetic Results Among Parkinson Disease Patients and Caregivers

Sakanaka

Waters

Levy

et al. 2013

Journal of Genetic Counseling

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The purpose of the study is to investigate Parkinson disease (PD) patients’ and caregivers’ knowledge of and interest in genetic testing. Gaucher disease (GD) results from recessive mutations in glucocerebrosidase (GBA). Both heterozygote GBA carriers and GD patients are at greater risk for PD. Studies regarding knowledge of and interest in genetic testing have been limited and have not offered genetic results to participants. In this study, 353 PD patients and 180 caregivers were recruited to a PD genetic study. The association between GD, GBA mutations and PD was described to participants who reported their familiarity with genetic terms, answered questions on genetic concepts, and indicated their interest in knowing if they may have GD (two GBA mutations) and other genetic information that could impact their health. Ninety-three-percent of participants were interested in receiving GBA results; however, only 51.6% of PD participants and 55.6% of caregivers knew that “scientists have identified genes associated with a higher risk of developing PD.” PD patients may benefit from education and genetic counseling on the implications of genetic testing.

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“…Overestimation of personal cancer risk is frequently reported by individuals with cancer [5–9]. Additionally, cancer worries are a critical concern for survivors and their family members and have been linked to increased anxiety, emotional distress, and impaired role functioning [10–12].…”

Section: Introductionmentioning

confidence: 99%

“…Perception of cancer risk has consistently been cited as a major factor influencing the decision to undergo genetic counseling and testing by women at increased risk of inherited breast or ovarian cancer [5–9]. Overestimation of an individual’s risk status has been associated with several negative outcomes, including increased anxiety and distress for one’s self and family members [9, 13], lower perception of control over cancer [9], depression [9], and excessive hyper-vigilance in screening practices [6].…”

Section: Introductionmentioning

confidence: 99%

Risk perception and cancer worries in families at increased risk of familial breast/ovarian cancer

et al. 2008

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While families at increased risk for familial breast/ovarian cancer continue to overestimate their cancer risk with increased cancer worries about the future, few studies have examined factors that affect inherited cancer risk perception and cancer worries in both survivors and unaffected female relatives. The purpose of this study was to examine variables that may affect cancer worries and risk perceptions from a family-based perspective in a racially diverse, community-based, random sample of 146 dyads consisting of adult female breast and/or ovarian cancer survivors and their unaffected female relatives (N = 292). Results indicated that coping style, self-efficacy, partner’s income, family role relationship, and cancer risk perception were significant contributors to the survivors’ and their unaffected relatives’ cancer worries. Significant variables for perception of cancer risk for both survivors and relatives included income, race, family history of cancer, and cancer worries. Relatives had a higher perception of cancer risk, whereas survivors had more cancer worries. Additionally, the level of cancer worries reported by one member of the dyad was related to the amount of worries reported by the other. The results from this study underscore the importance of clinicians addressing concerns of both affected and unaffected members of families at increased risk of cancer to assist them in managing cancer worries and having realistic risk appraisals to make informed decisions about their own and their family’s health surveillance options.

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Attitudes, Knowledge, and Risk Perceptions of Women With Breast and/or Ovarian Cancer Considering Testing for BRCA1 and BRCA2

Cited by 122 publications

References 28 publications

The Importance of Paternal Family History in Hereditary Breast Cancer Is Underappreciated by Health Care Professionals

The Importance of Paternal Family History in Hereditary Breast Cancer Is Underappreciated by Health Care Professionals

Knowledge of and Interest in Genetic Results Among Parkinson Disease Patients and Caregivers

Risk perception and cancer worries in families at increased risk of familial breast/ovarian cancer

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