Atypical Carcinoid Tumor of the Larynx: A Light Microscopic and Ultrastructural Study

Mills, Stacey E.; Johns, Michael E.

doi:10.1001/archotol.1984.00800270062016

Cited by 36 publications

(13 citation statements)

References 10 publications

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“…Subsequently, a considerable number of such cases have been reported as carcinoids, atypical carcinoids, malignant carcinoids, and neuroendocrine carcinomas (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). In some of these earlier discussions, the cytologic and clinical features of the tumors were overtly malignant, yet the term carcinoid tumor was applied without further modification, emphasizing the nomenclature problem discussed above.…”

Section: Neuroendocrine Carcinomas and Related Neoplasms (Group 1)mentioning

confidence: 99%

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

2002

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Tumors exhibiting neuroectodermal differentiation occur throughout the body, and the diverse tissues of the head and neck give rise to a wide assortment of these neoplasms. Neuroectodermal neoplasms may be divided into lesions showing primarily epithelial differentiation (Group I, neuroendocrine carcinomas) and a more diverse group (Group II) of nonepithelial neoplasms. This article reviews these neuroectodermal tumors of the head and neck with emphasis on the neuroendocrine carcinomas and their nomenclature. The author believes that with regard to Group I tumors, the older terminology of carcinoid, atypical carcinoid, and small cell carcinoma should be replaced by subclassifications of well-differentiated, moderately differentiated, and poorly differentiated neuroendocrine carcinoma. The latter category should be further subdivided into small cell and large cell variants. Neuroendocrine carcinomas, particularly the moderately differentiated subtype, are often underdiagnosed in the head and neck region. In the larynx, these tumors are the most common form of nonsquamous carcinoma. Poorly differentiated neuroendocrine carcinoma of small cell type is most common in the salivary glands but can occur elsewhere in the region. The large cell subtype of poorly differentiated neuroendocrine carcinoma has not been well documented in this region. However, the most likely candidate for this tumor category is the so-called sinonasal undifferentiated carcinoma. Group II tumors discussed include olfactory neuroblastoma, malignant melanoma, and Ewing's sarcoma. In addition, differential diagnostic problems related to Group I and II tumors are reviewed in detail. This article reviews and updates our understanding of neuroectodermal neoplasms arising in the head and neck. The focus is on tumors that exclusively involve this region or show a strong predilection to occur here.

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Section: Neuroendocrine Carcinomas and Related Neoplasms (Group 1)mentioning

confidence: 99%

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

2002

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“…None of the cases described presented with a carcinoid syndrome. Assays of serotonin or of its urinary metabolite, 5-hydroxy-indoleacetic acid [Gapany-Gapanavicius and Kenan, 1981;DuvalI et al, 1983;Mills and Johns, 1984; this study], were shown to be normal. This may be explained by the fact that the SED cells have a secretory specialization ac cording to their localization.…”

Section: Discussionmentioning

confidence: 53%

Carcinoid Tumors of the Larynx

Guerrier

Lallemant

Charlin

et al. 1985

ORL

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“…It is probable, however, that they may arise from either the diffuse neuroendocrine system or from uncommitted stem cells capable of neuroendocrine differentiation [14,16,17],…”

Section: Discussionmentioning

confidence: 99%

Carcinoid Tumor of the Larynx

El‐Naggar

Batsakis

1991

ORL

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Typical carcinoid neoplasms of the larynx are extremely rare tumors. The total number of known and documented cases is likely no more than 13. The neoplasm mainly affects males at an average age of 58 years and appears grossly as a polypoid or sessile submucosal nodule with an average 1.8 cm in size. Their predominant location is the supraglottis with the arytenoid and the aryepiglottic fold being the most frequent sites. Histologically, they are characterized by organoid architecture, uniform cellular features and lack of pleomorphism, necrosis and mitosis. Typical laryngeal carcinoids are less aggressive than their atypical counterparts but late distant metastasis and death may occur. The management of these neoplasms is conservative surgery.

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Atypical Carcinoid Tumor of the Larynx: A Light Microscopic and Ultrastructural Study

Cited by 36 publications

References 10 publications

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

Carcinoid Tumors of the Larynx

Carcinoid Tumor of the Larynx

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