Atypical cilia in ciliated cysts of the parathyroid glands of dogs exposed to ozone

Pemsingh, Ramjeet S.; Atwal, O. S.; MacPherson, R.B.

doi:10.1016/s0232-1513(85)80021-9

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Often these follicles have been called parathyroid cysts. Typical cysts in parathyroid glands have been reported before only occasionally (Godwin, 1937b;Rother and Wendler, 1968;Pemsingh et al, 1985). The differences between the cysts in parathyroid I11 and these in parathyroid IV have been clarified in the present study.…”

Section: Discussionsupporting

confidence: 65%

Immunohistochemical demonstration of keratins in the cysts of thyroid glands, parathyroid glands, and C‐cell complexes of the dog

Kameda

1987

Am. J. Anat.

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Cyst structures were often detected in and around thyroid glands of the dog. The present study revealed the frequency of occurrence, the light microscopic features, and the immunoperoxidase reactions to anti-keratin and anti-19S-thyroglobulin antisera of each cyst located in parathyroid III, parathyroid IV, thymus IV, C-cell complexes, and thyroid parenchyma from 112 dogs. In each location, cysts showed characteristic features. In parathyroid III, the cysts were covered with single or pseudostratified epithelium composed of ciliated cells; whereas in parathyroid IV they were covered with keratinizing stratified squamous epithelium. In C-cell complexes, small cysts lined with small packed cells were predominant, and large cysts lined with single cuboidal cells or stratified squamous cells were also present. In thymus IV located in the close vicinity of parathyroid IV, cyst epithelium consisted of several types of cells showing variable features. In thyroid parenchyma, there were several types of cysts: some were covered with ciliated columnar cells, and others were covered with two or multilayers of small packed cells or cuboidal cells. In spite of these differences in appearance of the cysts located in different tissues, all their epithelia were immunoreactive to the keratin antisera, except for small cysts in C-cell complexes, which were regarded as immature structures. Thus, the presence of keratin filaments in epithelial cells seems to be a characteristic feature of all cysts. The lumens of each cyst contained variable amounts of amorphous materials, which showed colloid-like, flocculent, foamy, and granular features and were periodic acid-Schiff-positive in variable degrees, from weak to intense. Although the lumenal contents of the cysts in parathyroid III revealed no immunoreactivity for 19S-thyroglobulin, those in thyroid parenchyma, C-cell complexes, parathyroid IV, and thymus IV reacted strongly with the 19S-thyroglobulin antiserum.

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Section: Discussionsupporting

confidence: 65%

Immunohistochemical demonstration of keratins in the cysts of thyroid glands, parathyroid glands, and C‐cell complexes of the dog

Kameda

1987

Am. J. Anat.

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“…Therefore, the lesion was indeed a parathyroid adenoma displaying a morphology reminiscent of airway epithelium. As no fresh-frozen tissue was kept from the tumor, we could not perform electron microscopy to investigate the suspected cilia component more closely, but previous ultrastructural studies in parathyroid tumors may support the notion that subsets of cases may exhibit ciliated structures ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

“…When searching online repositories for similar findings, no credible descriptions of this phenomenon was identified, and the incidence of this type of parathyroid tumor is therefore assumed to be exceedingly low. On an experimental basis, ozone exposure in dogs has been found to prompt the development of ciliated cystic structures within the parathyroid glands ( 10 , 11 ). Even though the index patient is a construction worker (a profession associated to ozone exposure), we can neither rule out nor confirm that exposure to this substance in any way influenced the development of a parathyroid tumor with respiratory-like epithelium ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Parathyroid Adenoma With Respiratory-Like Epithelium: Case Report of a Potential Mimic With Unknown Etiology

Juhlin

Zedenius

2021

Front. Endocrinol.

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Parathyroid adenoma is a tumor composed of increased parenchymal tissue, often built-up by chief cells, transitional cells or oncocytic cells arranged in acinar or solid formations. Occasionally, rare histological patterns are reported, including cystic or trabecular arrangements. We present a 47 year-old male patient with primary hyperparathyroidism who underwent focused parathyroidectomy for a right inferior adenoma. Surgery was uneventful, but histologically, normal parathyroid tissue adjacent to a tumorous structure displaying a cystic growth pattern was detected. The cells lining the cyst walls appeared cylindrical and pseudo-stratified, vaguely reminiscent of a respiratory type of epithelium usually associated to branchial cleft cysts or thyroglossal cyst remnants, albeit with a tumorous appearance. The respiratory-like epithelium stained positive for parathyroid markers PTH and GATA3, thereby confirming them as parathyroid-derived. The patient was cured from surgery as he displayed normal calcium and PTH levels postoperatively, and is currently alive and well without signs of relapse 4 years after surgery. This is to our knowledge the first report of a parathyroid tumor displaying a respiratory-like epithelium. Experimentally, canine parathyroid glands can develop ciliated respiratory epithelium in response to inhalation of ozone. Our patient is a construction worker with a hypothetically increased risk of continuous ozone exposure. Although this association remains purely speculative, future investigations of this tumor phenotype could perhaps yield novel insights regarding the frequency of this histological variant, potential clinical associations, and clues regarding influencing factors.

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Occurrence of the parathyroid cyst in golden hamsters

Chen

Hayakawa

Emura

et al. 2000

Annals of Anatomy - Anatomischer Anzeiger

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Atypical cilia in ciliated cysts of the parathyroid glands of dogs exposed to ozone

Cited by 3 publications

References 15 publications

Immunohistochemical demonstration of keratins in the cysts of thyroid glands, parathyroid glands, and C‐cell complexes of the dog

Immunohistochemical demonstration of keratins in the cysts of thyroid glands, parathyroid glands, and C‐cell complexes of the dog

Parathyroid Adenoma With Respiratory-Like Epithelium: Case Report of a Potential Mimic With Unknown Etiology

Occurrence of the parathyroid cyst in golden hamsters

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