Atypical Cutaneous Fibrous Histiocytoma

Leyva, William H.; Cruz, Daniel J. Santa

doi:10.1097/00000372-198612000-00003

Cited by 56 publications

(18 citation statements)

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“…Therefore it would seem necessary to make a diagnostic distinction between DF and AFX on the basis of the clinical and histological findings. The most important histological criterion of DF is the absence of mitosis, in contrast to the high degree of mitotic activity and atypical mitosis ob served in AFX [1,3,4,8]. Our case lacked atypical mitosis, pleomorphism and diffuse cellular atypicality observed in AFX.…”

Section: Discussionmentioning

confidence: 58%

“…There were some atypical giant cells with multiple 70 Sato/Aiba/Maie/Tomita Giant Xanthomatous Dermatotibroma pyknotic nuclei in our case. It has been reported that atypi cal cells are occasionally present in DFs |8, 10), which are referred to as 'atypical' DFs [8]. Therefore, our case can be considered as atypical DF with xanthomatous expression.…”

Section: Discussionmentioning

confidence: 61%

“…Furthermore, AFX usually lacks acanthosis of the overlying epidermis on the tumor, while marked acanthosis was demonstrated in our case. A significant acanthosis is one of the characteristic findings of DF [8,9] and helps dis tinguish DF from AFX [4,8,9]. …”

Section: Discussionmentioning

confidence: 99%

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Giant Xanthomatous Dermatofibroma – A Case Distinguished Histologically and Immunohistochemically from Invasive Fibrohistiocytic Tumors

et al. 1995

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A 50-year-old woman presented with a skin tumor on her right calf. The tumor had been noticed 20 years previously and grew to more than 60 mm in diameter. The histological findings were characterized by numerous bland xanthomatous histiocytes and a few atypical giant cells with pyknotic nuclei, although mitotic figures were few. These findings led to the diagnosis of dermatofibroma with unusual xanthomatous expression. Immunohistochemical studies using several markers for histiocytes (lysozyme, α₁-antitrypsin, α₁-antichymotrypsin and anti-CD68 antibody), anti-factor-XIIIa antibody and anti-CD34 antibody supported the diagnosis.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 61%

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Giant Xanthomatous Dermatofibroma – A Case Distinguished Histologically and Immunohistochemically from Invasive Fibrohistiocytic Tumors

et al. 1995

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“…4 Immunhistologische Färbung mit einem monoklonalen Antikörper gegen CD34 (Immunotech, Frankreich). Die Gefäße sind deutlich positiv, während die Tumorzellen ungefärbt bleiben sektion kommt es häufig zu Rezidiven: In einer Studie wurde die Rezidivrate mit 3,4% bestimmt im Vergleich zu 0,2% bei nichtproliferativen Histiozytomen [1].Andere Autoren geben Rezidivraten von bis zu 26% an [3].Das BFZH wurden von anderen Autoren auch als "atypisches kutanes fibröses Histiozytom" [4],"invasives benignes Histiozytom" [5], "atypisches pseudosarkomatöses kutanes benignes fibröses Histiozytom" [6] oder als "tief penetrierendes Dermatofibrom" [7] bezeichnet.Abgesehen vom histopathologischen Charakter des Tumors, spielen auch der Durchmesser und die Lokalisation sowie das Geschlecht des Patienten offenbar eine Rolle bei der Rezidivhäufigkeit. Das BFH tritt prinzipiell an allen Lokalisationen auf, auch palmoplantar, weitaus am häufigsten jedoch an den Extremitäten [8,9].…”

Section: Diskussionunclassified

Benignes zellreiches fibröses Histiozytom der Großzehe mit knöchernen Defekten des Nagelkranzfortsatzes

Kurzen

Hartschuh

2003

Hautarzt

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Fibrohistiocytic tumors are characterized by the presence of fibroblast like spindle cells and histiocytes. The benign fibrous histiocytoma (dermatofibroma, BFH) as well as the malignant dermatofibrosarcoma protuberans (DFSP) and the malignant fibrous histiocytoma (MFH) belong to this group. A recurrent painful, hard 2 cm tumor on the left hallux of a 54-year-old woman led to an erosion of the underlying phalanx. The patient had suffered from ingrown toenails for more than 10 years. Histologically there was a deep penetrating fibrohistiocytic tumor that grew in a storiform pattern with interspersed foam cells. The tumor was CD34 negative and mitoses were scarce. The diagnosis was benign cellular fibrous histiocytoma (BZFH). BZFH belong to the group of BFH with a high recurrence rate especially after incomplete removal. Damage to the underlying bone has not been reported so far.

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“…Histologically several variants of dermatofibroma are recognized: the fibrocollagenous or hypocellular [8], the cellular or histiocytic [9], the hemosiderotic [ 10] or angi omatoid [11], the palisading [12], the storiform [13], the epithelioid [14] and the atypical [15] categories. In many cases, however, this classification is largely artificial because of the occurrence of transitional forms in the same lesion.…”

Section: Introductionmentioning

confidence: 99%

Multinodular Hemosiderotic Dermatofibroma

Requena

Aguilar²,

Redondo³

et al. 1990

Dermatology

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We describe a patient who developed a pigmented plaque on the anterior aspect of his right knee clinically mimicking angiokeratoma circumscriptum or malignant melanoma. Histopathological examination demonstrated a multinodular hemosiderotic dermatofibroma in which the cellular tumor islands were separated by areas of hyalinized collagen. Multinucleated giant tumor cells were found in the lumen of a medium-size vein underlying the tumor. The differential diagnosis of angiomatoid malignant fibrous histiocytoma, a tumor with clinical and morphologic similarities, is discussed.

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Atypical Cutaneous Fibrous Histiocytoma

Cited by 56 publications

References 0 publications

Giant Xanthomatous Dermatofibroma – A Case Distinguished Histologically and Immunohistochemically from Invasive Fibrohistiocytic Tumors

Giant Xanthomatous Dermatofibroma – A Case Distinguished Histologically and Immunohistochemically from Invasive Fibrohistiocytic Tumors

Benignes zellreiches fibröses Histiozytom der Großzehe mit knöchernen Defekten des Nagelkranzfortsatzes

Multinodular Hemosiderotic Dermatofibroma

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