Atypical electrophysiologic findings in chronic inflammatory demyelinating polyneuropathy (CIDP) – diagnosis confirmed by nerve biopsy

Intravenous immunoglobulin response in treatment-nai ve chronic inflammatory demyelinating polyradiculoneuropathy

“…When the presence of pain was not reported and when analgaesics were not used we assumed that pain was not present. We did not analyse EMG findings because these examinations were not always performed in a standardised fashion in this two-centre study 12 24 25…”

Quantitative muscle ultrasound is useful for evaluating secondary axonal degeneration in chronic inflammatory demyelinating polyneuropathy

“…This finding might reflect the fact that the main pathology during the early phase of CIDP is segmental demyelination, unless secondary axonal degeneration occurs (Boukhris et al, 2004;Harbo et al, 2008;Kuwabara et al, 2006;Said, 2006). In the early stages of CIDP, muscle structures tend to be preserved due to the limited denervation.…”

“…Although the main pathology in CIDP is segmental demyelination, several studies demonstrated coexistence of axonal degeneration following segmental demyelination termed secondary axonal degeneration (Bouchard et al, 1999;Boukhris et al, 2004;Said, 2006;Sghirlanzoni et al, 2000). Differentiating segmental demyelination from secondary axonal degeneration in patients with CIDP is essential as the latter suggests unresponsiveness to medication and unfavorable prognosis (Bouchard et al, 1999;Iijima et al, 2005;Said, 2006;Sghirlanzoni et al, 2000).…”

Pain as the presenting symptom of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)

“…Numerous clinical forms have been described [4][5][6][7], among which the purely sensory forms [7,8] with paresthesiae, ataxia and occasional pain. However, pain is generally described as a secondary sign of the disease.…”